Transcutaneous spinal stimulation with pedaling among patoents with Parkinson's disease

• Project/Area Number: 18K10687
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 59010:Rehabilitation science-related
• Research Institution: Juntendo University
• Principal Investigator: Fujiwara Toshiyuki 順天堂大学, 保健医療学部, 教授 (50276375)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2018: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 歩行障害 / パーキンソン病 / 脊髄刺激 / リハビリテーション / ペダリング / 電気刺激 / 歩行

Outline of Final Research Achievements

We developed the transcutaneous spinal electrical stimulation system for patients with Parkinson's disease. We found that transcutaneous spinal electrical stimulation changed the spinal reciprocal inhibition and flexor reflex in patients with central nervous lesion. It was supposed that this transcutaneous spinal electrical stimulation could modulate the spinal locomotor circuit.

Academic Significance and Societal Importance of the Research Achievements

我々の開発した経皮的脊髄刺激システムは脳卒中やパーキンソン病等の中枢神経障害による歩行障害の改善の効果が期待される。通常のリハビリテーションのみでは改善できない歩行障害に対しての新しいリハビリテーション治療の一つとして期待される。

Research Products

• [Journal Article] Balance and gaot improvements of postoperative rehabilitation in patients with Parkinson's disease treated with subthalamic nucleus deep brain stimulation(STN-DBS). (2019)
  • Author(s): Sato K, Aita N, Hokari Y, Kitahara E, Tani M, Izawa N, Hatori K, Nakamura R, Sasaki F, Sekimoto S, Jo T, Oyama G, Umemura A, Hattori N, Fujiwara T
  • Journal Title: Parkinson's Disease Volume: 2019 Pages: 7104071-7104071
  • DOI: 10.1155/2019/7104071
  • Peer Reviewed / Open Access
• [Presentation] Transcutaneous spinal stimulation for gait rehabilitation among patients with stroke. (2020)
  • Author(s): Fujiwara T, Takahashi Y, Fujino Y, Matsuda T, Yamaguchi T, Honaga K
  • Organizer: 第11回 World congress for neurorehabilitation,
  • Int'l Joint Research
• [Presentation] 脊髄電気刺激を用いたリハビリテーション治療. (2020)
  • Author(s): 藤原俊之
  • Organizer: 第57回 日本リハビリテーション医学会学術集会
  • Invited
• [Presentation] Spinal stimulation for locomotion. Non-invasive brain and spinal stimulation - New insight of neuromodulation (2019)
  • Author(s): 藤原俊之
  • Organizer: 第3回 日本リハビリテーション医学会秋季学術集会
  • Invited
• [Presentation] Assessment of spinal reflex. Clinical neurophysiology in PRM. (2019)
  • Author(s): Fujiwara T
  • Organizer: 第13回 International Society of Physical and Rehabilitation Medicine World congress,
  • Int'l Joint Research / Invited
• [Presentation] 脊髄刺激による歩行機能再建. ニューロモデュレイション (2019)
  • Author(s): 藤原俊之
  • Organizer: 第10回 日本ニューロリハビリテーション学会学術集会,
  • Invited
• [Presentation] 神経可塑性を誘導する新しいリハビリテーション治療 (2018)
  • Author(s): 藤原俊之
  • Organizer: 第2回日本リハビリテーション医学会秋季学術集会
  • Invited
• [Presentation] 脊髄刺激による歩行機能再建 (2018)
  • Author(s): 藤原俊之
  • Organizer: 第48回日本臨床神経生理学会
  • Invited