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An optimal determination of simultaneous pulse-rate and -amplitude modulated electric stimulating waveform for cochlear implant devices

Research Project

Project/Area Number 18K10692
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 59010:Rehabilitation science-related
Research InstitutionKanto Gakuin University

Principal Investigator

Mino Hiroyuki  関東学院大学, 理工学部, 教授 (50190715)

Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords聴覚神経補綴 / 不規則点過程 / 聴神経線維モデル / 計算機シミュレーション / 最大尤度推定 / von Mises分布 / 消費電力節約 / 聴覚系神経補綴 / 聴覚系電気刺激 / パルスレート・振幅同時変調 / 情報理論的尺度 / 自己励起型不規則点過程 / パルス状電気刺激波形 / 変調方式
Outline of Final Research Achievements

In the present project, an optimal parameter set of simultaneous pulse-rate and -amplitude modulated (PRAM) electric stimuli was found such that the von Mises parameters in the spike trains in response to acoustic stimuli could be matched to those of electric stimuli through computer simulations using physiologically realistic auditory nerve fiber model. From the view point of saving electric energy, an parameter set of PRAM electric stimuli was also found for the von Mises parameters of acoustic stimuli with a specific range of pulse rates and a greater amplitude modulation depth. Therefore, it is concluded that the PRAM electric stimulating waveform designed on the basis of the present project may play a key role in improving the performance of cochlear implant devices.

Academic Significance and Societal Importance of the Research Achievements

本課題の研究成果の一部は、2019年に海外英文雑誌(Biological Cybernetics)に掲載されるとともに、2021年には国際会議(Society for Brain Mapping & Therapeutics 17th/18th Annual Congress, Los Angeles, CA, USA)のセッションAddressing Challenges in Cochlear Implants において招待講演として発表されており、これらのことは当該研究の学術的、社会的意義をいみじくも物語っている。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (33 results)

All 2022 2021 2020 2019 2018 Other

All Int'l Joint Research (4 results) Journal Article (4 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 4 results) Presentation (24 results) (of which Int'l Joint Research: 10 results,  Invited: 2 results) Remarks (1 results)

  • [Int'l Joint Research] カリフォルニア大学アーバイン校(米国)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] University of California, Irvine(米国)

    • Related Report
      2020 Research-status Report
  • [Int'l Joint Research] University of California, Irvine(米国)

    • Related Report
      2019 Research-status Report
  • [Int'l Joint Research] University of California at Irvine(米国)

    • Related Report
      2018 Research-status Report
  • [Journal Article] Random Synaptic Noise Can Generate θ-γ Phase Amplitude Coupling in a Hippocampal Neural Network Model with Sub-threshold Excitable Synaptic Stimuli2022

    • Author(s)
      森 亮介、簑 弘幸
    • Journal Title

      Transactions of Japanese Society for Medical and Biological Engineering

      Volume: 60 Issue: 1 Pages: 32-37

    • DOI

      10.11239/jsmbe.60.32

    • ISSN
      1347-443X, 1881-4379
    • Year and Date
      2022-03-10
    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pulse-frequency-dependent resonance in a population of pyramidal neuron models2022

    • Author(s)
      Ryosuke Mori, Hiroyuki Mino, and Dominique M. Durand
    • Journal Title

      Biological Cybernetics

      Volume: 116 Issue: 3 Pages: 363-375

    • DOI

      10.1007/s00422-022-00925-w

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Modeling of spike trains in auditory nerves with self-exciting point processes of the von Mises type2019

    • Author(s)
      Hiroyuki Mino
    • Journal Title

      Biological Cybernetics

      Volume: 113 Issue: 3 Pages: 347-356

    • DOI

      10.1007/s00422-019-00799-5

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Enhancement of Synaptic Transmission of Sub-threshold Current Stimulus with High Rate Pulsatile Electric Stimuli in a Recurrent Neuron Model2018

    • Author(s)
      森 亮介、簑 弘幸
    • Journal Title

      Transactions of Japanese Society for Medical and Biological Engineering

      Volume: 56 Issue: 4 Pages: 164-167

    • DOI

      10.11239/jsmbe.56.164

    • NAID

      130007605157

    • ISSN
      1347-443X, 1881-4379
    • Year and Date
      2018-08-10
    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Presentation] Neural Modeling in Auditory Prostheses2021

    • Author(s)
      Hiroyuki Mino
    • Organizer
      Society for Brain Mapping & Therapeutics 17th/18th Annual Congress
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Information rates of an anteroventral cochlear nucleus model in response to sinusoidally amplitude-modulated pulsatile electric stimuli2021

    • Author(s)
      Takeru Suzuki, and Hiroyuki Mino
    • Organizer
      10th International IEEE EMBS Conference on Neural Engineering, Virtual, 2021 May
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] High frequency stimulation can enhance phase-amplitude coupling in a neural network model with a weak excitatory synaptic transmission2021

    • Author(s)
      Ryosuke Mori, Hiroyuki Mino, Naoki Ishikawa and Dominique M. Durand
    • Organizer
      10th International IEEE EMBS Conference on Neural Engineering. Virtual, 2021 May
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 閾値未満の興奮性シナプス刺激が与えられた海馬ニューラルネットワークモデルにおける不規則なシナプスノイズによるθ-γ位相振幅結合の生成2021

    • Author(s)
      森 亮介、簑 弘幸
    • Organizer
      生体医工学シンポジウム2021
    • Related Report
      2021 Annual Research Report
  • [Presentation] 振動共振による前腹側蝸牛神経核モデルでの閾値未満シナプス電流刺激の伝送強化2021

    • Author(s)
      石川 直輝、簑 弘幸
    • Organizer
      日本生体医工学会専門別研究会 生体信号計測・解釈研究会(第65回), 2021年12月 Virtual
    • Related Report
      2021 Annual Research Report
  • [Presentation] パーキンソン病における脳深部刺激療法でのパルス状波形の制御2021

    • Author(s)
      鈴木 豪流、森 亮介、簑 弘幸
    • Organizer
      日本生体医工学会専門別研究会 生体信号計測・解釈研究会(第65回), 2021年12月 Virtual
    • Related Report
      2021 Annual Research Report
  • [Presentation] 海馬ニューラルネットワークモデルにおける不規則なシナプスノイズによる θ-γ 位相振幅結合の生成2021

    • Author(s)
      森 亮介、簑 弘幸
    • Organizer
      2021年度 統計数理研究所 共同研究集会「健康・医療情報学,生体計測・生体信号解析とその周辺2」 Virtual
    • Related Report
      2021 Annual Research Report
  • [Presentation] Statistical properties of neural spike trains in an auditory nerve fiber model stimulated by a simultaneous pulse rate- and amplitude-modulated (PRAM) waveform2020

    • Author(s)
      Naoki Ishikawa and Hiroyuki Mino
    • Organizer
      42nd Annual International Conference of the IEEE in Medicine and Biology Society
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Pulse Frequency-Dependent Resonance in a Population of Pyramidal Neuron Models with a Mixture of Sub- and Supra- Threshold Stimuli of Synaptic Weights2020

    • Author(s)
      Ryousuke Mori, Hiroyuki Mino, and Dominique M. Durand
    • Organizer
      42nd Annual International Conference of the IEEE in Medicine and Biology Society
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Encoding of sinusoidal information into the spike trains of auditory nerve fiber model with simultaneous rate- and amplitude-modulated pulsatile stimuli2020

    • Author(s)
      Hiroyuki Mino
    • Organizer
      Journal Club Zoom Meeting at Center for Hearing Research, University of California, Irvine (Prof. F.G. Zeng, Director)
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 自己励起点過程による視床腹側中間核での神経スパイク列のモデリング2020

    • Author(s)
      簑 弘幸、八名 和夫
    • Organizer
      日本生体医工学会専門別研究会 生体信号計測・解釈研究会(第63回)
    • Related Report
      2020 Research-status Report
  • [Presentation] レートと振幅が同時変調されたパルス状電気刺激波形に対する聴神経モデルの応答特性:パルスレート最大値の影響2020

    • Author(s)
      簑 弘幸
    • Organizer
      統計数理研究所 共同研究集会「生体信号・イメージングデータ解析に基づく医療・健康データ科学の展開2」
    • Related Report
      2020 Research-status Report
  • [Presentation] Information transmission in an auditory nerve fiber model stimulated by a simultaneous pulse rate- and amplitude-modulated (PRAM) waveform2019

    • Author(s)
      Yumeko Kawase and Hiroyuki Mino
    • Organizer
      41st Annual International Conference of the IEEE in Medicine and Biology Society
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] High rate pulsatile stimuli can improve information transmission of sub-threshold stimuli in a hippocampal CA1 neural network model2019

    • Author(s)
      Ryousuke Mori, Hiroyuki Mino, and Dominique M. Durand
    • Organizer
      41st Annual International Conference of the IEEE in Medicine and Biology Society
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 音響刺激と電気刺激に対する聴神経線維モデルのスパイク応答の統計的性質:電気刺激波形設計への展開2019

    • Author(s)
      簑 弘幸
    • Organizer
      第58回日本生体医工学会大会
    • Related Report
      2019 Research-status Report
  • [Presentation] 抑制性介在ニューロンが海馬 CA1 ニューラルネットワークモデルのスパイク間隔を遅延させる2019

    • Author(s)
      森 亮介、簑 弘幸
    • Organizer
      生体医工学シンポジウム2019
    • Related Report
      2019 Research-status Report
  • [Presentation] レートと振幅が同時変調されたパルス状電気刺激に対する聴神経モデルの応答特性:Neurogramによる検討2019

    • Author(s)
      簑 弘幸
    • Organizer
      統計数理研究所 共同研究集会「生体信号・イメージングデータ解析に基づく医療・健康データ科学の展開2」
    • Related Report
      2019 Research-status Report
  • [Presentation] 自己励起点過程による神経の不応期特性の推定2019

    • Author(s)
      簑 弘幸、八名 和夫
    • Organizer
      日本生体医工学会専門別研究会 生体信号計測・解釈研究会(第61回)
    • Related Report
      2019 Research-status Report
  • [Presentation] Statistical Properties of Neural Spike Trains in Response to Rate-Amplitude-Modulated Pulsatile Electric Stimuli in an Auditory Nerve Fiber Model2018

    • Author(s)
      Mako Iwasaki, Hiroyuki Mino
    • Organizer
      40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] High Rate Pulsatile Stimuli can Enhance the Detection of Sub-threshold Signals in a Hippocampal CA1 Neural Network Model2018

    • Author(s)
      Ryousuke Mori, Hiroyuki Mino, Minato Kawaguchi, Dominique M. Durand
    • Organizer
      40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Evaluating the estimation accuracy in random point processes for the analysis of neural spike trains2018

    • Author(s)
      Hiroyuki Mino, Kazuo Yana
    • Organizer
      第57回日本生体医工学会大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 高レートパルス状電気刺激による循環型ニューロンモデルでの閾値未満シナプス電流刺激の伝達強化2018

    • Author(s)
      森 亮介、簑 弘幸
    • Organizer
      生体医工学シンポジウム2018
    • Related Report
      2018 Research-status Report
  • [Presentation] 聴覚系神経補綴における最適電気刺激波形の設計2018

    • Author(s)
      簑 弘幸
    • Organizer
      統計数理研究所 共同研究集会「生体信号・イメージングデータ解析に基づく医療・健康データ科学の展開」
    • Related Report
      2018 Research-status Report
  • [Presentation] von Mises型自己励起点過程におけるパラメータの最尤推定:神経の不応期特性の推定2018

    • Author(s)
      簑 弘幸、八名 和夫
    • Organizer
      日本生体医工学会専門別研究会 生体信号計測・解釈研究会(第59回)
    • Related Report
      2018 Research-status Report
  • [Remarks] 関東学院大学理工学部人間医工学研究室

    • URL

      http://hst.kanto-gakuin.ac.jp/lab03.html

    • Related Report
      2021 Annual Research Report

URL: 

Published: 2018-04-23   Modified: 2023-01-30  

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