| Project/Area Number |
18K10717
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 59010:Rehabilitation science-related
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| Research Institution | Yokohama City University |
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Principal Investigator |
KIKUCHI Naohisa 横浜市立大学, 医学研究科, 客員准教授 (90315789)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 脊髄損傷 / 慢性期 / 痙縮 / ボツリヌス治療 / 髄注バクロフェン治療 / 経頭蓋磁気刺激 / データベース研究 / 多施設間研究 / ADL / QOL / ボツリヌス療法 / リハビリテーション治療 / 多施設間検討 |
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| Outline of Final Research Achievements |
For patients with SCI, an approach that combines botulinum toxin type A treatment for spasticity, aggressive spasticity treatment with continuous intrathecal baclofen administration therapy, repeated transcranial magnetic stimulation therapy, and electrical stimulation therapy for peripheral nerves in combination with rehabilitation therapy. , A study was conducted to examine how upper limb motor function, ADL, and QOL can be improved. Significant improvements were observed in the spasticity treatment group, transcranial and peripheral electrical stimulation groups in terms of the level and function of spinal cord injury and its changes. Regarding spasticity, there was a clear improvement in spasticity treatment. There was also a slight improvement in the transcranial and peripheral electrical stimulation groups. ADL was also significantly improved in both groups, demonstrating a positive effect on QOL.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究は脊髄損傷患者に対して痙縮に対するA型ボツリヌス毒素治療と持続的髄腔内バクロフェン投与療法による積極的痙縮治療、反復経頭蓋磁気刺激治療、末梢神経に対する電気刺激治療をリハビリテーション治療と組み合わせて行うアプローチにより、上肢運動機能、ADL、QOLをいかに改善できるかを検証するために施行した。本研究では回復期以降の脊髄損傷患者に対して痙縮治療および大脳への反復磁気刺激および末梢電気刺激治療と集中的なリハビリテーション治療を施行することによる効果を多施設間で介入検討するものであり、この成果は慢性期脊髄損傷患者の運動機能、ADL、QOLに対して大きな寄与を与えることができたものと考える。
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