Adaptation and feasibility of the botulinum toxin therapy with transcranial direct current stimulation for upper limb spasticity of stroke patients
| Project/Area Number |
18K10733
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 59010:Rehabilitation science-related
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
Saeki Satoru 産業医科大学, 医学部, 教授 (20269070)
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| Co-Investigator(Kenkyū-buntansha) |
松嶋 康之 産業医科大学, 医学部, 准教授 (10412660)
伊藤 英明 産業医科大学, 医学部, 講師 (30609201)
白石 純一郎 産業医科大学, 医学部, 非常勤医師 (20525430)
蜂須賀 明子 産業医科大学, 医学部, 助教 (90646936)
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| Project Period (FY) |
2018-04-01 – 2023-03-31
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| Project Status |
Completed (Fiscal Year 2022)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 非侵襲的大脳刺激 / ボツリヌス毒素療法 / 脳卒中 / リハビリテーション / 痙縮治療 / 経頭蓋直流電気刺激 / 痙縮 |
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| Outline of Final Research Achievements |
Botulinum neurotoxin (BoNT) injection is effective for reducing spasticity, but the duration of effectiveness is limited for only 3 months, therefore multiple injections are necessary over the long term. Transcranial direct current stimulation (tDCS) is a potentially novel strategy for reducing post-stroke spasticity, and tDCS might prolong the duration of reducing spasticity by BoNT therapy. The purpose of this study was to examine problems with adaptation and feasibility for the BoNT therapy with anodal tDCS for upper limb spasticity of stroke patients as a preliminary study. A single-blind, randomized sham (placebo)-controlled pretest/posttest study was conducted for stroke patients. This study was completed without the need for stopping per medical monitor. No adverse effects were seen during the intervention. Based on the results of this study, BoNT and tDCS appear to be safe, feasible, and well tolerated in stroke patients.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究により、脳卒中片麻痺上肢痙縮に対するボツリヌス療法（BoNTA）と経頭蓋直流電気刺激の効果増強や効果延長などの併用効果がみられる例も確認されたことから、BoNTA追加施注までの期間を延長することが可能となり、対象患者の身体的負担ならびに医療費の軽減が期待される。また、先進的リハビリの発展の一助につながる。
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Report
(6 results)
Research Products
(23 results)
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[Journal Article] Efficacy and safety of incobotulinumtoxinA in post stroke upper limb spasticity in Japanese subjects: results from randomized, double blind, placebo controlled study (J-;PURE)2020
Author(s)
Masakado Y, Abo M, Kondo K, Saeki S, Saitoh E, Dekundy A, Hanschmann A, Kaji R, J-PURE Study Group.
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Journal Title
Journal of Neurology
Volume: 267
Issue: 7
Pages: 1-13
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] 片麻痺上肢に対する中枢性及び末梢性電気刺激併用療法の最適化に関する研究-第1報2019
Author(s)
徳永美月, 森山利幸, 手嶋美帆, 杉本香苗, 蜂須賀明子, 白石純一郎, 伊藤英明, 加藤徳明, 越智光宏, 松嶋康之, 佐伯 覚
Organizer
第56回 日本リハビリテーション医学会学術集会
Related Report
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[Presentation] 片麻痺上肢に対する中枢性及び末梢性電気刺激併用療法の最適化に関する研究-第2報2019
Author(s)
森山利幸, 徳永美月, 手嶋美帆, 杉本香苗, 蜂須賀明子, 白石純一郎, 伊藤英明, 加藤徳明, 越智光宏, 松嶋康之, 佐伯 覚
Organizer
第56回 日本リハビリテーション医学会学術集会
Related Report
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