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The study on the role of pulmonary rehabilitation and irisin in enhancing physical activity in COPD

Research Project

Project/Area Number 18K10738
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 59010:Rehabilitation science-related
Research InstitutionAkita University

Principal Investigator

Sano Masaaki  秋田大学, 保健管理センター, 准教授 (30323140)

Co-Investigator(Kenkyū-buntansha) 塩谷 隆信  秋田大学, 医学系研究科, 教授 (90170852)
Project Period (FY) 2018-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
KeywordsCOPD / 身体活動性 / 呼吸リハビリテーション / アイリシン / マイオカイン / 呼吸リビリテーション
Outline of Final Research Achievements

In patients with COPD undergoing pulmonary rehabilitation (PR), we investigated: 1) the longitudinal association of myokines, including Irisin, with physical activity (PA), and 2) the potential of myokines as biomarkers.
The study involved 29 stable COPD patients participating in outpatient PR at Akita City Hospital. Of these, 18 patients were enrolled in an 8-week program aimed at enhancing PA. We measured myokine concentrations (Irisin, GDF-8, BDNF), inflammatory cytokine concentrations, PA (number of steps, mean time of activity of 3 METs or more, body composition, quadriceps strength, respiratory function, and exercise tolerance. After 8 weeks of intervention, the number of steps significantly increased from a median of 2367 to 2452 steps/day, but there were no significant changes in myokines or inflammatory cytokines. No significant correlation was found between myokines and PA. Caution is required when interpreting myokine concentrations in COPD patients continuing PR.

Academic Significance and Societal Importance of the Research Achievements

アイリシン分泌増加への運動の急性効果は認められているが、PRを継続するCOPD患者では、運動やPAの増加を通してマイオカイン濃度は変化している。本研究は、PRメンテナンスプログラムに参加するCOPD患者において、アイリシン、GDF-8、BDNFとPAの間に有意相関を認めなかったことより、長期的なPR介入が行われているCOPD患者のマイオカインはPAに関連するバイオマーカーとして習慣的に用い難い可能性、PAを目的とした歩行を中心とした介入は、マイオカインの増加には関連しない可能性を示した。COPD患者のアイリシン分泌におけるPRの時間的効果、種類、強度等が及ぼす影響にはさらなる検討を要する。

Report

(7 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (36 results)

All 2023 2022 2021 2020 2019 2018

All Journal Article (15 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 15 results,  Open Access: 15 results) Presentation (19 results) Book (2 results)

  • [Journal Article] Tracheal small cell carcinoma with RB1 Splice site mutation treated by chemoradiotherapy: A case report2023

    • Author(s)
      Sakamoto Sho、Takeda Masahide、Izumiya Yuka、Okuda Yuji、Asano Mariko、Sano Masaaki、Sato Kazuhiro、Nakayama Katsutoshi
    • Journal Title

      Current Problems in Cancer: Case Reports

      Volume: 10 Pages: 100245-100245

    • DOI

      10.1016/j.cpccr.2023.100245

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Nationwide retrospective observational study of idiopathic dendriform pulmonary ossification: clinical features with a progressive phenotype2022

    • Author(s)
      Nishioka Yasuhiko、Toyoda Yuko、Sano Masaaki et al.
    • Journal Title

      BMJ Open Respiratory Research

      Volume: 9 Issue: 1 Pages: e001337-e001337

    • DOI

      10.1136/bmjresp-2022-001337

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Objective physical activity level is associated with rectus femoris muscle echo‐intensity in patients with chronic obstructive pulmonary disease2022

    • Author(s)
      Okura Kazuki、Iwakura Masahiro、Kawagoshi Atsuyoshi、Sugawara Keiyu、Takahashi Hitomi、Shioya Takanobu
    • Journal Title

      The Clinical Respiratory Journal

      Volume: 16 Issue: 8 Pages: 572-580

    • DOI

      10.1111/crj.13528

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prediction of Low-intensity Physical Activity in Stable Patients with Chronic Obstructive Pulmonary Disease2022

    • Author(s)
      KAWAGOSHI Atsuyoshi、IWAKURA Masahiro、FURUKAWA Yutaka、SUGAWARA Keiyu、TAKAHASHI Hitomi、SHIOYA Takanobu
    • Journal Title

      Physical Therapy Research

      Volume: 25 Issue: 3 Pages: 143-149

    • DOI

      10.1298/ptr.E10208

    • ISSN
      2189-8448
    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Estimation of minimal clinically important difference for quadriceps and inspiratory muscle strength in older outpatients with chronic obstructive pulmonary disease: a prospective cohort study2021

    • Author(s)
      IWAKURA Masahiro、OKURA Kazuki、KUBOTA Mika、SUGAWARA Keiyu、KAWAGOSHI Atsuyoshi、TAKAHASHI Hitomi、SHIOYA Takanobu
    • Journal Title

      Physical Therapy Research

      Volume: 24 Issue: 1 Pages: 35-42

    • DOI

      10.1298/ptr.E10049

    • NAID

      130008028204

    • ISSN
      2189-8448
    • Year and Date
      2021-04-20
    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Functionally relevant threshold of inspiratory muscle strength in patients with chronic obstructive pulmonary disease2021

    • Author(s)
      Iwakura Masahiro、Wakasa Masahiko、Okura Kazuki、Kawagoshi Atsuyoshi、Sugawara Keiyu、Takahashi Hitomi、Shioya Takanobu
    • Journal Title

      Respiratory Medicine

      Volume: 188 Pages: 106625-106625

    • DOI

      10.1016/j.rmed.2021.106625

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] ABCG2 C421A polymorphisms affect exposure of the epidermal growth factor receptor inhibitor gefitinib2020

    • Author(s)
      Sakamoto Sho、Sato Kazuhiro、Takita Yuri、Izumiya Yuka、Kumagai Naho、Sudo Kazuhisa、Hasegawa Yukiyasu、Yokota Hayato、Akamine Yumiko、Okuda Yuji、Asano Mariko、Takeda Masahide、Sano Masaaki、Miura Masatomo、Nakayama Katsutoshi
    • Journal Title

      Investigational New Drugs

      Volume: 38 Issue: 6 Pages: 1687-1695

    • DOI

      10.1007/s10637-020-00946-x

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Diaphragm thickening assessed by ultrasonography is lower than healthy adults in patients with chronic obstructive pulmonary disease2020

    • Author(s)
      Okura Kazuki、Iwakura Masahiro、Shibata Kazuyuki、Kawagoshi Atsuyoshi、Sugawara Keiyu、Takahashi Hitomi、Satake Masahiro、Shioya Takanobu
    • Journal Title

      The Clinical Respiratory Journal

      Volume: 14 Issue: 6 Pages: 521-526

    • DOI

      10.1111/crj.13161

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The association between systemic inflammation and the time spent in posture and movement during daytime in patients with chronic obstructive pulmonary disease and lower weight2020

    • Author(s)
      Kawagoshi Atsuyoshi、Iwakura Masahiro、Furukawa Yutaka、Sugawara Keiyu、Takahashi Hitomi、Shioya Takanobu
    • Journal Title

      Journal of Physical Therapy Science

      Volume: 32 Issue: 12 Pages: 804-809

    • DOI

      10.1589/jpts.32.804

    • NAID

      130007953533

    • ISSN
      0915-5287, 2187-5626
    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Gait characteristics and their associations with clinical outcomes in patients with chronic obstructive pulmonary disease2019

    • Author(s)
      Iwakura Masahiro、Okura Kazuki、Shibata Kazuyuki、Kawagoshi Atsuyoshi、Sugawara Keiyu、Takahashi Hitomi、Shioya Takanobu、Wakasa Masahiko
    • Journal Title

      Gait & Posture

      Volume: 74 Pages: 60-65

    • DOI

      10.1016/j.gaitpost.2019.08.012

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] An autopsy case of anaplastic lymphoma kinase-positive lung cancer exacerbated in a short period of time: a case report2019

    • Author(s)
      Takeda Masahide、Sato Kazuhiro、Sakamoto Sho、Suzuki Maya、Izumiya Yuka、Kumagai Naho、Sudo Kazuhisa、Okuda Yuji、Asano Mariko、Sano Masaaki、Omori Yasufumi、Nakayama Katsutoshi
    • Journal Title

      Journal of Medical Case Reports

      Volume: 13 Issue: 1 Pages: 118-118

    • DOI

      10.1186/s13256-019-2054-3

    • Related Report
      2019 Research-status Report 2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Blepharoptosis Due to Sarcoidosis-Induced Horner Syndrome2019

    • Author(s)
      Takeda Masahide、Sato Kazuhiro、Sano Masaaki、Sakamoto Sho、Izumiya Yuka、Kumagai Naho、Sudo Kazuhisa、Asano Mariko、Okuda Yuji、Nakayama Katsutoshi
    • Journal Title

      American Journal of Respiratory and Critical Care Medicine

      Volume: 印刷中 Issue: 1 Pages: 101-102

    • DOI

      10.1164/rccm.201807-1285im

    • Related Report
      2019 Research-status Report 2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Phase II trial of induction chemotherapy with carboplatin and paclitaxel plus bevacizumab in patients with stage IIIA to IV nonsquamous non-small cell lung cancer2019

    • Author(s)
      Imai Kazuhiro、Nakagawa Taku、Matsuzaki Ikuo、Orino Kimito、Saito Hajime、Sato Kazuhiro、Sano Masaaki、Nakayama Katsutoshi、Sato Yusuke、Motoyama Satoru、Nomura Kyoko、Shibata Hiroyuki、Minamiya Yoshihiro
    • Journal Title

      Surgery Today

      Volume: - Issue: 8 Pages: 1-8

    • DOI

      10.1007/s00595-019-01791-z

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prevalence of airflow limitation in primary care clinics in Akita prefecture.2018

    • Author(s)
      Sano Masaaki, Shioya Takanobu, Sato Kazuhiro, Ito Hiroshi, Watanabe Hiroyuki, Nakayama Katsutoshi.
    • Journal Title

      Akita Journal of Medicine

      Volume: 45 Pages: 37-44

    • NAID

      120006549582

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mucus plugging in allergic bronchopulmonary aspergillosis: Implication of the eosinophil DNA traps2018

    • Author(s)
      Omokawa Ayumi、Ueki Shigeharu、Kikuchi Yuta、Takeda Masahide、Asano Mariko、Sato Kazuhiro、Sano Masaaki、Ito Hiroshi、Hirokawa Makoto
    • Journal Title

      Allergology International

      Volume: 67 Issue: 2 Pages: 280-282

    • DOI

      10.1016/j.alit.2017.08.002

    • NAID

      130006721874

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 身体活動量向上を目指した呼吸リハビリテーションが慢性閉塞性肺疾患患者のマイオカインに与える影響2023

    • Author(s)
      古川大, 川越厚良,岩倉正浩,菅原慶勇,佐野正明,塩谷隆信
    • Organizer
      第33回日本呼吸ケア・リハビリテーション学会学術集会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 身体活動量向上を目指した呼吸リハビリテーションが慢性閉塞性肺疾患患者のアイリシンに与える効果2023

    • Author(s)
      古川大, 川越厚良,岩倉正浩,菅原慶勇,佐野正明,塩谷隆信
    • Organizer
      10回日本呼吸ケア・リハビリテーション学会 東北支部学術集会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 令和4年度の本学学生における健康・生活実態調査結果の検討2023

    • Author(s)
      佐野正明,安保智秋,荻原佐智代,藤原友紀子,伏見雅人
    • Organizer
      第60回全国大学保健管理研究集会東北地方研究集会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 本学学生における健康・生活実態調査結果の 新型コロナウイルス感染症発生前後での比較2022

    • Author(s)
      佐野 正明、安保 智秋、藤原 友紀子、荻原 佐智代、伏見 雅人
    • Organizer
      第59回全国大学保健管理研究集会東北地方研究集会
    • Related Report
      2022 Research-status Report
  • [Presentation] 呼吸不全が急激に進行し死の転帰をたどった肺腫瘍血栓性微小血管症 の1例2022

    • Author(s)
      泉谷有可,佐藤一洋,工藤健太郎,大本瑛己,滝田友里 ,坂本祥,浅野真理子 ,奥田佑道 ,竹田正秀 ,佐野正明 ,山本洋平 ,中山勝敏
    • Organizer
      第115回日本呼吸器学会東北地方会
    • Related Report
      2022 Research-status Report
  • [Presentation] 呼吸リハビリテーション維持プログラムを継続した慢性閉塞性肺疾患患者の身体活動量の長期的な変化2022

    • Author(s)
      古川大、岩倉正浩、川越厚良、照井佳乃、菅原慶勇、高橋仁美、佐竹將宏、塩谷隆信
    • Organizer
      第32回日本呼吸ケア・リハビリテーション学会学術集会
    • Related Report
      2022 Research-status Report
  • [Presentation] 学生健診で発見された胸部異常陰影の一例2021

    • Author(s)
      佐野 正明、安保 智秋、藤原 友紀子、荻原 佐智代、伏見 雅人
    • Organizer
      第58回全国大学保健管理研究集会東北地方研究集会
    • Related Report
      2021 Research-status Report
  • [Presentation] 安定期COPD患者における低強度の推定活動量の検討2021

    • Author(s)
      川越厚良,岩倉正浩,古川大,菅原慶勇,若林育子,塩谷孝信
    • Organizer
      第31回日本呼吸ケア・リハビリテーション学会学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] 外科的肺生検で診断に至った関節リウマチ関連間質性肺疾患(RA-ILD)の一例2021

    • Author(s)
      旭ルリ子,泉谷有可,長谷川幸保,五島哲,坂本祥,浅野真理子,奥田佑道,竹田正秀,本間光信,佐野正明,佐藤一洋,中山勝敏
    • Organizer
      第113回日本呼吸器学会東北地方会
    • Related Report
      2021 Research-status Report
  • [Presentation] 禁煙とステロイド治療を行うも増悪を示した剥離性間質性肺炎(DIP)の一例2021

    • Author(s)
      泉谷有可,坂本祥,浅野真理子,折野公人,阿部史人,五島哲,旭ルリ子,奥田佑道,竹田正秀,佐野正明,三浦一樹,佐藤一洋,中山勝敏
    • Organizer
      第113回日本呼吸器学会東北地方会
    • Related Report
      2021 Research-status Report
  • [Presentation] びまん性肺病変とネフローゼ症候群に対して、ステロイドが著効した一例2021

    • Author(s)
      大本瑛己,熊谷奈保,滝田友里,泉谷有可,坂本祥,長谷川幸保,浅野真理子,奥田佑道,竹田正秀,佐藤一洋,佐野正明,本間光信,中山勝敏
    • Organizer
      第112回日本呼吸器学会東北地方会
    • Related Report
      2021 Research-status Report
  • [Presentation] 気管狭窄を伴う甲状腺原発悪性リンパ腫の一例2021

    • Author(s)
      滝田友里,泉谷有可,熊谷奈保,坂本祥,浅野真理子,奥田佑道,竹田正秀,佐藤一洋,佐野正明,中山勝敏
    • Organizer
      第112回日本呼吸器学会東北地方会
    • Related Report
      2021 Research-status Report
  • [Presentation] オシメルチニブによる薬剤性肺障害が疑われた高齢者肺癌の1例2021

    • Author(s)
      浅野真理子,佐藤一洋,坂本 祥,奥田佑道,竹田正秀,佐野正明,横田隼人,三浦昌朋,大田秀隆,中山勝敏
    • Organizer
      第32回日本老年医学会東北地方会
    • Related Report
      2021 Research-status Report
  • [Presentation] 慢性好酸球性肺炎(CEP)患者のBALFに観察された好酸球ETosis.2020

    • Author(s)
      竹田正秀, 坂本祥,佐藤一洋,植木重治,宮部結,佐野正明,奥田佑道,浅野真理子,長谷川幸保,熊谷奈保,廣川誠,中山勝敏.
    • Organizer
      第60回日本呼吸器学会学術講演会
    • Related Report
      2020 Research-status Report
  • [Presentation] in vitroにおけるシャルコー・ライデン結晶の形成機構2019

    • Author(s)
      竹田正秀, 植木重治, 福地峰世, 宮部結, 面川歩, 嵯峨知生, 守時由起, 佐藤一洋, 佐野正明, 中山勝敏, 廣川誠
    • Organizer
      第67回日本アレルギー学会学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] 気道上皮細胞からのサイトカイン産生, 粘液産生におけるPhosphoinositide 3-kinase γの関わり2019

    • Author(s)
      竹田正秀, 佐藤一洋, 植木重治, 丹典子, 泉谷有可, 熊谷奈保, 坂本祥, 須藤和久, 長谷川幸保, 浅野真理子, 奥田佑道, 佐野正明, 中山勝敏
    • Organizer
      第59回日本呼吸器学会学術講演会
    • Related Report
      2019 Research-status Report
  • [Presentation] COPD における呼吸リハと薬物療法による身体活動性向上:システマテックレビュー2018

    • Author(s)
      塩谷隆信,佐藤晋,佐野正明,佐竹將宏, 照井佳乃,古川 大,岩倉正浩,川越厚良, 菅原慶勇,高橋仁美
    • Organizer
      第28回 日本呼吸ケア・リハビリテーション学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] アレルギー性気管支肺アスペルギルス症の粘液栓への好酸球Etosisの関与2018

    • Author(s)
      竹田正秀,植木重治,Neves Josiane,福地峰世,今野泰典,佐藤一洋, 佐野正明,,廣川誠, 蛇澤晶,浅野浩一郎
    • Organizer
      第67回日本アレルギー学会学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] ABCG2 C421A 遺伝子多型とPPI の併用によるgefitinib の血中濃度の変動に関する検討2018

    • Author(s)
      坂本祥,佐藤一洋,奥田佑道,横田隼人,赤嶺由美子,泉谷有可,熊谷奈保,須藤和久,長谷川幸保,浅野真理子,竹田正秀,佐野正明,三浦昌朋,中山勝敏
    • Organizer
      第59回日本肺癌学会学術集会
    • Related Report
      2018 Research-status Report
  • [Book] リハ実践テクニック 呼吸ケア2021

    • Author(s)
      塩谷 隆信、高橋 仁美、佐野正明ら
    • Total Pages
      440
    • Publisher
      メジカルビュー社
    • ISBN
      9784758320368
    • Related Report
      2021 Research-status Report 2020 Research-status Report
  • [Book] 動画でわかる呼吸リハビリテーション2020

    • Author(s)
      高橋仁美、塩谷隆信、宮川哲夫,佐野正明ら
    • Total Pages
      340
    • Publisher
      中山書店
    • ISBN
      9784521748344
    • Related Report
      2020 Research-status Report

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Published: 2018-04-23   Modified: 2025-01-30  

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