Plasticity of cervical interneurons and recovery of motor function
| Project/Area Number |
18K10759
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 59010:Rehabilitation science-related
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| Research Institution | Kyorin University |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2019: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2018: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 神経リハビリテーション / 脊髄可塑性 / 運動イメ―ジ / 皮質脊髄路 / 介在ニューロン / 錐体路 / 頸髄介在ニューロン / 可塑性 / 脊髄損傷 / 運動機能再建 / 脊髄介在ニューロン / 運動機能回復 / 巧緻運動 |
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| Outline of Final Research Achievements |
It remains unclear whether motor imagery influences corticospinal (CST) excitation mediated via cervical interneurons, which may be important for functional motor recovery in animals. To investigate this, we examined the spatial facilitation of motor-evoked potentials (MEPs) induced by combined stimulation (CS) of CST and peripheral nerves. Transcranial magnetic stimulation (TMS) to motor cortex and electrical stimulation of ulnar nerve at wrist (NERVE) were delivered separately or in combination with 10 ms of inter-stimulus intervals. During motor imagery of elbow flexion, CS facilitated MEPs, compared to the summation of responses obtained with either only TMS or NERVE. The enhancement was larger than control task. The findings suggest that motor imagery facilitates CST excitation, mediated by cervical interneurons. Thus, motor imagery may be a useful tool for contributing motor reacquisition.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究は、外部刺激による脊髄神経回路網への可塑性誘導法の開発し、運動機能再建のための新たな神経リハビリテーション法を検討するものである。当該脊髄可塑性誘導法は、当初、筋の活動を多少起こせる方のみが対象であった。しかしながら、今回、随意運動が極度に困難な方でも、運動を脳内に想起することさえできれば、脊髄に可塑性誘導できることがわかり、当該症例でも運動機能を改善させる可能性があることが示唆された。
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Report
(5 results)
Research Products
(20 results)
