中枢性交感神経制御による慢性心不全患者QOL改善のリハビリテーションモデル構築

• Project/Area Number: 18K10775
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 59010:Rehabilitation science-related
• Research Institution: University of Toyama
• Principal Investigator: 城宝 秀司 富山大学, 学術研究部医学系, 講師 (90334721)
• Project Period (FY): 2018-04-01 – 2023-03-31
• Project Status: Discontinued (Fiscal Year 2022)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2020: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2019: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2018: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 慢性心不全 / 交感神経活動 / 心臓リハビリテーション / 体重減少 / カヘキシア

Outline of Annual Research Achievements

連続血圧血行動態測定ベーシックシステムを用い慢性心不全患者を対象にして測定を継続する予定であったが、新型コロナ蔓延の影響で停滞した。また学会でのデータ収集や学会報告の機会も制限された。このため研究費の使用に影響した。

Research Products

• [Journal Article] Responders to Sodium-Glucose Cotransporter 2 Inhibitors in Improving Left Ventricular Function (2022)
  • Author(s): Nakagaito M, Imamura T, Joho S, Ushijima R, Nakamura M, Kinugawa K.
  • Journal Title: International Heart Journal Volume: 63 Issue: 3 Pages: 550-557
  • DOI: 10.1536/ihj.22-027
  • ISSN: 1349-2365, 1349-3299
  • Year and Date: 2022-05-30
  • Peer Reviewed / Open Access
• [Journal Article] Primary Cardiac Angiosarcoma Accompanying Cardiac Tamponade (2022)
  • Author(s): Hori M, Imamura T, Tanaka S, Ueno H, Joho S, Fukahara K, Kajiura S, Kinugawa K.
  • Journal Title: Internal Medicine Volume: 61 Issue: 7 Pages: 1015-1019
  • DOI: 10.2169/internalmedicine.8250-21
  • NAID: 130008089749
  • ISSN: 0918-2918, 1349-7235
  • Year and Date: 2022-04-01
  • Peer Reviewed / Open Access
• [Journal Article] Factors Associated with Recurrent Heart Failure during Incorporating SGLT2 Inhibitors in Patients Hospitalized for Acute Decompensated Heart Failure. (2022)
  • Author(s): Nakagaito M, Imamura T, Joho S, Ushijima R, Nakamura M, Kinugawa K.
  • Journal Title: J Clin Med Volume: 11 Issue: 17 Pages: 5027-5027
  • DOI: 10.3390/jcm11175027
  • Peer Reviewed / Open Access
• [Journal Article] ベルイシグアト (2022)
  • Author(s): 城宝秀司、絹川弘一郎
  • Journal Title: 日本内科学会雑誌 Volume: 111 Pages: 255-262
  • Peer Reviewed
• [Journal Article] Efficacy of Continuing SGLT2 Inhibitors on Outcomes in Patients with Acute Decompensated Heart Failure (2021)
  • Author(s): Nakagaito M, Imamura T, Joho S, Ushijima R, Nakamura M, Kinugawa K.
  • Journal Title: International Heart Journal Volume: 62 Issue: 4 Pages: 885-890
  • DOI: 10.1536/ihj.21-022
  • NAID: 130008069195
  • ISSN: 1349-2365, 1349-3299
  • Year and Date: 2021-07-30
  • Peer Reviewed / Open Access
• [Journal Article] Renoprotective effects of sodium glucose cotransporter 2 inhibitors in type 2 diabetes patients with decompensated heart failure. (2021)
  • Author(s): Nakagaito M, Imamura T, Joho S, Ushijima R, Nakamura M, Kinugawa K.
  • Journal Title: BMC Cardiovasc Disord. Volume: 21 Issue: 1 Pages: 347-347
  • DOI: 10.1186/s12872-021-02163-7
  • Peer Reviewed / Open Access
• [Journal Article] Selexipag for the treatment of chronic thromboembolic pulmonary hypertension. (2021)
  • Author(s): Ogo T, Shimokawahara H, Kinoshita H, Sakao S, Abe K, Matoba S, Motoki H, Takama N, Ako J, Ikeda Y, Joho S, Maki H, Saeki T, Sugano T, Tsujino I, Yoshioka K, Shiota N, Tanaka S, Yamamoto C, Tanabe N, Tatsumi K; Study Group.
  • Journal Title: Eur Respir J. Volume: 25 Issue: 1 Pages: 2101694-2101694
  • DOI: 10.1183/13993003.01694-2021
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Initial Experience With Tafamidis Treatment for Transthyretin Amyloid Cardiomyopathy (2020)
  • Author(s): Nakamura M, Imamura T, Hori M, Ushijima R, Joho S, Kinugawa K.
  • Journal Title: Circulation Reports Volume: 2 Issue: 8 Pages: 420-424
  • DOI: 10.1253/circrep.CR-20-0062
  • NAID: 130007885735
  • ISSN: 2434-0790
  • Year and Date: 2020-08-07
  • Peer Reviewed / Open Access
• [Journal Article] Sympathetic overactivation predicts body weight loss in patients with heart failure (2020)
  • Author(s): Joho S, Ushijima R, Nakagaito M, Kinugawa K.
  • Journal Title: Autonomic Neuroscience Volume: 223 Pages: 1-6
  • DOI: 10.1016/j.autneu.2019.102625
  • Peer Reviewed / Open Access
• [Journal Article] Comparison of Canagliflozin, Dapagliflozin and Empagliflozin Added to Heart Failure Treatment in Decompensated Heart Failure Patients With Type 2 Diabetes Mellitus (2019)
  • Author(s): Nakagaito M, Joho S, Ushijima R, Nakamura M, Kinugawa K.
  • Journal Title: Circulation Reports Volume: 1 Issue: 10 Pages: 405-413
  • DOI: 10.1253/circrep.CR-19-0070
  • NAID: 130007726531
  • ISSN: 2434-0790
  • Year and Date: 2019-10-10
  • Peer Reviewed / Open Access
• [Journal Article] Blood Oxygen, Sleep Disordered Breathing, and Respiratory Instability in Patients With Chronic Heart Failure ― PROST Subanalysis ― (2019)
  • Author(s): Tobushi T, Kadokami K, Takagawa J, Dohi K, Joho S, Wada O, Momomura SI, Koyama T, Haruki N, Ando SI, Asanoi H, PROST Investigators
  • Journal Title: Circulation Reports Volume: 1 Issue: 10 Pages: 414-421
  • DOI: 10.1253/circrep.CR-19-0068
  • NAID: 130007726523
  • ISSN: 2434-0790
  • Year and Date: 2019-10-10
  • Peer Reviewed / Open Access
• [Journal Article] Relation between prognostic impact of hyperuricemia and sympathetic overactivation in patients with heart failure. (2019)
  • Author(s): Joho S, Ushijima R, Nakagaito M, Kinugawa K.
  • Journal Title: J Cardiol. Volume: 73 Issue: 3 Pages: 233-239
  • DOI: 10.1016/j.jjcc.2018.08.008
  • Peer Reviewed
• [Journal Article] Multicenter, Prospective Study on Respiratory Stability During Recovery From Deterioration of Chronic Heart Failure (2018)
  • Author(s): Takagawa J, Asanoi H, Tobushi T, Kumagai N, Kadokami T, Dohi K, Joho S, Wada O, Koyama T, Haruki N, Ando SI, Momomura SI; PROST Investigators.
  • Journal Title: Circulation Journal Volume: 83 Issue: 1 Pages: 164-173
  • DOI: 10.1253/circj.CJ-18-0519
  • NAID: 130007550400
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2018-12-25
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] Relation between prognostic impact of mitral regurgitation and sympathetic overactivation in patients with heart failure. (2022)
  • Author(s): Shuji Joho, Ryuichi Ushijima, Koichiro Kinugawa.
  • Organizer: 第86回日本循環器学会
• [Presentation] 富山大学附属病院における循環器疾患の治療と心臓リハビリテーションの現状 (2022)
  • Author(s): 城宝秀司
  • Organizer: リハビリテーション医学会北陸地方会
  • Invited
• [Presentation] Relation Between Prognostic Impact of Mitral Regurgitation and Sympathetic Overactivation in Patients With Heart Failure (2022)
  • Author(s): Shuji Joho, Ryuichi Ushijima, Koichiro Kinugawa
  • Organizer: 第86回日本循環器学会 学術集会
• [Presentation] Renoprotective Effects of Sodium Glucose Cotransporter 2 Inhibitors in Type 2 Diabetes Patients with Decompensated Heart Failure (2022)
  • Author(s): Masaki Nakagaito, Teruhiko Imamura, Shuji Joho, Ryuichi Ushijima, Makiko Nakamura, Koichiro Kinugawa
  • Organizer: 第86回日本循環器学会 学術集会
• [Presentation] 急性期病院の高齢心疾患患者におけるADL指標による自宅退院の予測 (2021)
  • Author(s): 森田慎也、城宝秀司、新出敏治、後藤範子、堀正和、中垣内昌樹、牛島龍一、中村牧子、今西理恵子、服部憲明
  • Organizer: 第27回日本心臓リハビリテーション学会
• [Presentation] 富山大学附属病院におけるペムブロリズマブ使用後の心筋障害の検討 (2021)
  • Author(s): 城宝秀司、石川雄大、梶浦新也、林龍二、絹川弘一郎
  • Organizer: 第4回日本腫瘍循環器学会
• [Presentation] 肺動脈内膜切除術後の慢性血栓塞栓性肺高血圧症患者に対する心臓リハビリテーションの経験 (2021)
  • Author(s): 城宝秀司、牛島龍一、森田慎也、新出敏治、後藤範子、中村牧子、堀正和、絹川弘一郎
  • Organizer: 日本心臓リハビリテーション学会第7回北陸支部地方会
• [Presentation] 慢性血栓塞栓性肺高血圧患者におけるBPAによる運動指標への影響 (2021)
  • Author(s): 牛島龍一、城宝秀司、上野博志、中村牧子、絹川弘一郎
  • Organizer: 日本心臓リハビリテーション学会第7回北陸支部地方会
• [Presentation] 急性期病院の高齢心疾患患者におけるADL指標による自宅退院の予測 (2021)
  • Author(s): 森田慎也、城宝秀司、新出敏治、後藤範子、堀正和、中垣内昌樹、牛島龍一、中村牧子、今西理恵子、服部憲明
  • Organizer: 日本心臓リハビリテーション学会第7回北陸支部地方会
• [Presentation] Sympathetic Nerve Activity is a Sensitive Marker of Body Weight Loss in Patients with Heart Failure (2021)
  • Author(s): Shuji Joho, Ryuichi Ushijima, Masaki Nakagaito, Koichiro Kinugawa
  • Organizer: 第85回日本循環器学会学術集会
• [Presentation] Comparison of SGLT2 inhibitors induced diuretic action in diabetic patients with heart failure with reduced, midrange amd preserved ejection fraction. (2020)
  • Author(s): Masaki Nakagaito, Shuji Joho, Ryuichi Ushijima, Makiko Nakamura, Tadakazu Hirai, Koichiro Kinugawa
  • Organizer: 第84回日本循環器学会 学術集会
• [Presentation] Comparison of Canagliflozin, Dapagliflozin and Empagliflozin added to heart failure treatment in decompensated heart failure with type 2 diabetes. (2020)
  • Author(s): Masaki Nakagaito, Shuji Joho, Ryuichi Ushijima, Makiko Nakamura, Koichiro Kinugawa
  • Organizer: 第84回日本循環器学会学術集会
• [Presentation] 要介護認定を有する高齢循環器疾患患者におけるBarthel Indexおよび下位項目と自宅退院成否との関係 (2020)
  • Author(s): 森田慎也、城宝秀司、新出敏治、後藤範子、堀正和、中垣内正樹、牛島龍一、中村牧子、今西理恵子、服部憲明
  • Organizer: 第26回日本心臓リハビリテーション学会学術集会
• [Presentation] 慢性血栓塞栓性肺高血圧患者におけるBPAによる運動指標への影響 (2020)
  • Author(s): 牛島龍一、城宝秀司、上野博志、中村牧子、絹川弘一郎
  • Organizer: 日本心臓リハビリテーション学会第6回北陸支部地方会
• [Presentation] 急性期病院の高齢心疾患患者におけるADL指標による自宅退院の予測 (2020)
  • Author(s): 森田慎也、城宝秀司、新出敏治、後藤範子、堀正和、中垣内正樹、牛島龍一、中村牧子、今西理恵子、服部憲明
  • Organizer: 日本心臓リハビリテーション学会第6回北陸支部地方会
• [Presentation] Short-term effects of dapagliflozin versus canagliflozin on acute decompensated heart failure in patients with type 2 diabetes. (2019)
  • Author(s): Masaki Nakagaito, Shuji Joho, Ryuichi Ushijima, Makiko Nakamura, Tadakazu Hirai, Koichiro Kinugawa.
  • Organizer: 2019年ESC
  • Int'l Joint Research
• [Presentation] 慢性心不全における中枢性交感神経活動と体重減少との関係 (2019)
  • Author(s): 城宝秀司、牛島龍一、中垣内昌樹、中村牧子、絹川弘一郎
  • Organizer: 第32回日本マイクロニューログラフィー学会
• [Presentation] 慢性血栓塞栓性肺高血圧症におけるキサンチンオキシダーゼ活性の検討 (2019)
  • Author(s): 城宝秀司、野手姫代美、牛島龍一、中垣内昌樹、中村牧子、絹川弘一郎
  • Organizer: 第67回日本心臓病学会
• [Presentation] Influence of sympathetic nerve activity on prognostic impact of anemia in patients with heart failure (2019)
  • Author(s): Shuji Joho, Ryuichi Ushijima, Masaki Nakagaito, Koichiro Kinugawa.
  • Organizer: 第83回日本循環器学会総会
• [Presentation] Effect of sodium-glucose cotransporter 2 inhibitors in combination with loop diuretics on neurohumoral factor in heart failure patients with diabetes (2019)
  • Author(s): Masaki Nakagaito, Shuji Joho, Ryuichi Ushijima, Makiko Nakamura, Tadakazu Hirai, Koichiro Kinugawa.
  • Organizer: 第83回日本循環器学会総会
• [Presentation] Relation between HbA1c level and effectiveness of SGLT2 inhibitors in diabetic patients with acute decompensated heart failure. (2019)
  • Author(s): Masaki Nakagaito, Shuji Joho, Ryuichi Ushijima, Makiko Nakamura, Koichiro Kinugawa.
  • Organizer: 第22回日本心不全学会
• [Presentation] Is prognostic impact of hyperuricemia homogenous in patients with heart failure? (2018)
  • Author(s): Shuji Joho, Ryuichi Ushijima, Masaki Nakagaito, Makiko Nakamura, Tadakazu Hirai, Koichiro Kinugawa.
  • Organizer: 2018年ESC
  • Int'l Joint Research
• [Presentation] Relationship between malnutrition and sympathetic overactivation in patients with chronic heart failure. (2018)
  • Author(s): Ryuichi Ushijima, Shuji Joho, Masaki Nakagaito, Makiko Nakamura, Tadakazu Hirai, Koichiro Kinugawa.
  • Organizer: 2018年ESC
  • Int'l Joint Research
• [Presentation] Influence of sympathetic nerve activity on prognostic impact of anemia in patients with heart failure. (2018)
  • Author(s): Shuji Joho, Ryuichi Ushijima, Masaki Nakagaito, Koichiro Kinugawa. Influence of sympathetic nerve activity on prognostic impact of anemia in patients with heart failure. AHA annual session 2018年11月11日 シカゴ。
  • Organizer: 2018年AHA
  • Int'l Joint Research
• [Presentation] Relation between HbA1c level and effectiveness of SGLT2 inhibitors in diabetic patients with acute decompensated heart failure. (2018)
  • Author(s): Masaki Nakagaito, Shuji Joho, Ryuichi Ushijima, Makiko Nakamura, Tadakazu Hirai, Koichiro Kinugawa
  • Organizer: 2018年AHA
  • Int'l Joint Research
• [Presentation] Adaptive servo-ventilation improves GNRI and albumin level in patients with heart failure. (2018)
  • Author(s): Shuji Joho, Ryuichi Ushijima, Tadakazu Hirai, Koichiro Kinugawa.
  • Organizer: 第82回日本循環器学会総会
• [Presentation] 慢性心不全における中枢性交感神経活動と体重減少との関係 (2018)
  • Author(s): 城宝秀司、牛島龍一、中垣内昌樹、中村牧子、絹川弘一郎
  • Organizer: 第24回日本心臓リハビリテーション学会
• [Presentation] 慢性心不全における2型糖尿病による交感神経活動と予後との関係 (2018)
  • Author(s): 城宝秀司、牛島龍一、中垣内昌樹、中村牧子、絹川弘一郎
  • Organizer: 第66回日本心臓病学会
• [Presentation] Influence of sympathetic nerve activity on prognostic impact of anemia in patients with heart failure. (2018)
  • Author(s): Shuji Joho, Ryuichi Ushijima, Masaki Nakagaito, Koichiro Kinugawa
  • Organizer: 第22回日本心不全学会
• [Book] Noninvasive positive pressure ventilation. Update of Non-Pharmacological Therapy for Heart Failure (Kinugawa Koichiro, Imamura Teruhiko), (2020)
  • Author(s): Shuji Joho
  • Total Pages: 11
  • Publisher: Springer
  • ISBN: 9789811548437
• [Book] 日本臨牀 増刊号 心不全（第二版）中 (2019)
  • Author(s): 城宝秀司
  • Total Pages: 4
  • Publisher: 日本臨牀社