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中枢性交感神経制御による慢性心不全患者QOL改善のリハビリテーションモデル構築

Research Project

Project/Area Number 18K10775
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 59010:Rehabilitation science-related
Research InstitutionUniversity of Toyama

Principal Investigator

城宝 秀司  富山大学, 学術研究部医学系, 講師 (90334721)

Project Period (FY) 2018-04-01 – 2023-03-31
Project Status Discontinued (Fiscal Year 2022)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2019: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2018: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords慢性心不全 / 交感神経活動 / 心臓リハビリテーション / 体重減少 / カヘキシア
Outline of Annual Research Achievements

連続血圧血行動態測定ベーシックシステムを用い慢性心不全患者を対象にして測定を継続する予定であったが、新型コロナ蔓延の影響で停滞した。また学会でのデータ収集や学会報告の機会も制限された。このため研究費の使用に影響した。

Report

(5 results)
  • 2022 Annual Research Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (44 results)

All 2022 2021 2020 2019 2018

All Journal Article (13 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 13 results,  Open Access: 11 results) Presentation (29 results) (of which Int'l Joint Research: 5 results,  Invited: 1 results) Book (2 results)

  • [Journal Article] Responders to Sodium-Glucose Cotransporter 2 Inhibitors in Improving Left Ventricular Function2022

    • Author(s)
      Nakagaito M, Imamura T, Joho S, Ushijima R, Nakamura M, Kinugawa K.
    • Journal Title

      International Heart Journal

      Volume: 63 Issue: 3 Pages: 550-557

    • DOI

      10.1536/ihj.22-027

    • ISSN
      1349-2365, 1349-3299
    • Year and Date
      2022-05-30
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Primary Cardiac Angiosarcoma Accompanying Cardiac Tamponade2022

    • Author(s)
      Hori M, Imamura T, Tanaka S, Ueno H, Joho S, Fukahara K, Kajiura S, Kinugawa K.
    • Journal Title

      Internal Medicine

      Volume: 61 Issue: 7 Pages: 1015-1019

    • DOI

      10.2169/internalmedicine.8250-21

    • NAID

      130008089749

    • ISSN
      0918-2918, 1349-7235
    • Year and Date
      2022-04-01
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Factors Associated with Recurrent Heart Failure during Incorporating SGLT2 Inhibitors in Patients Hospitalized for Acute Decompensated Heart Failure.2022

    • Author(s)
      Nakagaito M, Imamura T, Joho S, Ushijima R, Nakamura M, Kinugawa K.
    • Journal Title

      J Clin Med

      Volume: 11 Issue: 17 Pages: 5027-5027

    • DOI

      10.3390/jcm11175027

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] ベルイシグアト2022

    • Author(s)
      城宝秀司、絹川弘一郎
    • Journal Title

      日本内科学会雑誌

      Volume: 111 Pages: 255-262

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Efficacy of Continuing SGLT2 Inhibitors on Outcomes in Patients with Acute Decompensated Heart Failure2021

    • Author(s)
      Nakagaito M, Imamura T, Joho S, Ushijima R, Nakamura M, Kinugawa K.
    • Journal Title

      International Heart Journal

      Volume: 62 Issue: 4 Pages: 885-890

    • DOI

      10.1536/ihj.21-022

    • NAID

      130008069195

    • ISSN
      1349-2365, 1349-3299
    • Year and Date
      2021-07-30
    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Renoprotective effects of sodium glucose cotransporter 2 inhibitors in type 2 diabetes patients with decompensated heart failure.2021

    • Author(s)
      Nakagaito M, Imamura T, Joho S, Ushijima R, Nakamura M, Kinugawa K.
    • Journal Title

      BMC Cardiovasc Disord.

      Volume: 21 Issue: 1 Pages: 347-347

    • DOI

      10.1186/s12872-021-02163-7

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Selexipag for the treatment of chronic thromboembolic pulmonary hypertension.2021

    • Author(s)
      Ogo T, Shimokawahara H, Kinoshita H, Sakao S, Abe K, Matoba S, Motoki H, Takama N, Ako J, Ikeda Y, Joho S, Maki H, Saeki T, Sugano T, Tsujino I, Yoshioka K, Shiota N, Tanaka S, Yamamoto C, Tanabe N, Tatsumi K; Study Group.
    • Journal Title

      Eur Respir J.

      Volume: 25 Issue: 1 Pages: 2101694-2101694

    • DOI

      10.1183/13993003.01694-2021

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Initial Experience With Tafamidis Treatment for Transthyretin Amyloid Cardiomyopathy2020

    • Author(s)
      Nakamura M, Imamura T, Hori M, Ushijima R, Joho S, Kinugawa K.
    • Journal Title

      Circulation Reports

      Volume: 2 Issue: 8 Pages: 420-424

    • DOI

      10.1253/circrep.CR-20-0062

    • NAID

      130007885735

    • ISSN
      2434-0790
    • Year and Date
      2020-08-07
    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sympathetic overactivation predicts body weight loss in patients with heart failure2020

    • Author(s)
      Joho S, Ushijima R, Nakagaito M, Kinugawa K.
    • Journal Title

      Autonomic Neuroscience

      Volume: 223 Pages: 1-6

    • DOI

      10.1016/j.autneu.2019.102625

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparison of Canagliflozin, Dapagliflozin and Empagliflozin Added to Heart Failure Treatment in Decompensated Heart Failure Patients With Type 2 Diabetes Mellitus2019

    • Author(s)
      Nakagaito M, Joho S, Ushijima R, Nakamura M, Kinugawa K.
    • Journal Title

      Circulation Reports

      Volume: 1 Issue: 10 Pages: 405-413

    • DOI

      10.1253/circrep.CR-19-0070

    • NAID

      130007726531

    • ISSN
      2434-0790
    • Year and Date
      2019-10-10
    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Blood Oxygen, Sleep Disordered Breathing, and Respiratory Instability in Patients With Chronic Heart Failure ― PROST Subanalysis ―2019

    • Author(s)
      Tobushi T, Kadokami K, Takagawa J, Dohi K, Joho S, Wada O, Momomura SI, Koyama T, Haruki N, Ando SI, Asanoi H, PROST Investigators
    • Journal Title

      Circulation Reports

      Volume: 1 Issue: 10 Pages: 414-421

    • DOI

      10.1253/circrep.CR-19-0068

    • NAID

      130007726523

    • ISSN
      2434-0790
    • Year and Date
      2019-10-10
    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Relation between prognostic impact of hyperuricemia and sympathetic overactivation in patients with heart failure.2019

    • Author(s)
      Joho S, Ushijima R, Nakagaito M, Kinugawa K.
    • Journal Title

      J Cardiol.

      Volume: 73 Issue: 3 Pages: 233-239

    • DOI

      10.1016/j.jjcc.2018.08.008

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Multicenter, Prospective Study on Respiratory Stability During Recovery From Deterioration of Chronic Heart Failure2018

    • Author(s)
      Takagawa J, Asanoi H, Tobushi T, Kumagai N, Kadokami T, Dohi K, Joho S, Wada O, Koyama T, Haruki N, Ando SI, Momomura SI; PROST Investigators.
    • Journal Title

      Circulation Journal

      Volume: 83 Issue: 1 Pages: 164-173

    • DOI

      10.1253/circj.CJ-18-0519

    • NAID

      130007550400

    • ISSN
      1346-9843, 1347-4820
    • Year and Date
      2018-12-25
    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Relation between prognostic impact of mitral regurgitation and sympathetic overactivation in patients with heart failure.2022

    • Author(s)
      Shuji Joho, Ryuichi Ushijima, Koichiro Kinugawa.
    • Organizer
      第86回日本循環器学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 富山大学附属病院における循環器疾患の治療と心臓リハビリテーションの現状2022

    • Author(s)
      城宝秀司
    • Organizer
      リハビリテーション医学会北陸地方会
    • Related Report
      2022 Annual Research Report 2021 Research-status Report
    • Invited
  • [Presentation] Relation Between Prognostic Impact of Mitral Regurgitation and Sympathetic Overactivation in Patients With Heart Failure2022

    • Author(s)
      Shuji Joho, Ryuichi Ushijima, Koichiro Kinugawa
    • Organizer
      第86回日本循環器学会 学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] Renoprotective Effects of Sodium Glucose Cotransporter 2 Inhibitors in Type 2 Diabetes Patients with Decompensated Heart Failure2022

    • Author(s)
      Masaki Nakagaito, Teruhiko Imamura, Shuji Joho, Ryuichi Ushijima, Makiko Nakamura, Koichiro Kinugawa
    • Organizer
      第86回日本循環器学会 学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] 急性期病院の高齢心疾患患者におけるADL指標による自宅退院の予測2021

    • Author(s)
      森田慎也、城宝秀司、新出敏治、後藤範子、堀正和、中垣内昌樹、牛島龍一、中村牧子、今西理恵子、服部憲明
    • Organizer
      第27回日本心臓リハビリテーション学会
    • Related Report
      2021 Research-status Report
  • [Presentation] 富山大学附属病院におけるペムブロリズマブ使用後の心筋障害の検討2021

    • Author(s)
      城宝秀司、石川雄大、梶浦新也、林龍二、絹川弘一郎
    • Organizer
      第4回日本腫瘍循環器学会
    • Related Report
      2021 Research-status Report
  • [Presentation] 肺動脈内膜切除術後の慢性血栓塞栓性肺高血圧症患者に対する心臓リハビリテーションの経験2021

    • Author(s)
      城宝秀司、牛島龍一、森田慎也、新出敏治、後藤範子、中村牧子、堀正和、絹川弘一郎
    • Organizer
      日本心臓リハビリテーション学会第7回北陸支部地方会
    • Related Report
      2021 Research-status Report
  • [Presentation] 慢性血栓塞栓性肺高血圧患者におけるBPAによる運動指標への影響2021

    • Author(s)
      牛島龍一、城宝秀司、上野博志、中村牧子、絹川弘一郎
    • Organizer
      日本心臓リハビリテーション学会第7回北陸支部地方会
    • Related Report
      2021 Research-status Report
  • [Presentation] 急性期病院の高齢心疾患患者におけるADL指標による自宅退院の予測2021

    • Author(s)
      森田慎也、城宝秀司、新出敏治、後藤範子、堀正和、中垣内昌樹、牛島龍一、中村牧子、今西理恵子、服部憲明
    • Organizer
      日本心臓リハビリテーション学会第7回北陸支部地方会
    • Related Report
      2021 Research-status Report
  • [Presentation] Sympathetic Nerve Activity is a Sensitive Marker of Body Weight Loss in Patients with Heart Failure2021

    • Author(s)
      Shuji Joho, Ryuichi Ushijima, Masaki Nakagaito, Koichiro Kinugawa
    • Organizer
      第85回日本循環器学会学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] Comparison of SGLT2 inhibitors induced diuretic action in diabetic patients with heart failure with reduced, midrange amd preserved ejection fraction.2020

    • Author(s)
      Masaki Nakagaito, Shuji Joho, Ryuichi Ushijima, Makiko Nakamura, Tadakazu Hirai, Koichiro Kinugawa
    • Organizer
      第84回日本循環器学会 学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] Comparison of Canagliflozin, Dapagliflozin and Empagliflozin added to heart failure treatment in decompensated heart failure with type 2 diabetes.2020

    • Author(s)
      Masaki Nakagaito, Shuji Joho, Ryuichi Ushijima, Makiko Nakamura, Koichiro Kinugawa
    • Organizer
      第84回日本循環器学会学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] 要介護認定を有する高齢循環器疾患患者におけるBarthel Indexおよび下位項目と自宅退院成否との関係2020

    • Author(s)
      森田慎也、城宝秀司、新出敏治、後藤範子、堀正和、中垣内正樹、牛島龍一、中村牧子、今西理恵子、服部憲明
    • Organizer
      第26回日本心臓リハビリテーション学会学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] 慢性血栓塞栓性肺高血圧患者におけるBPAによる運動指標への影響2020

    • Author(s)
      牛島龍一、城宝秀司、上野博志、中村牧子、絹川弘一郎
    • Organizer
      日本心臓リハビリテーション学会第6回北陸支部地方会
    • Related Report
      2020 Research-status Report
  • [Presentation] 急性期病院の高齢心疾患患者におけるADL指標による自宅退院の予測2020

    • Author(s)
      森田慎也、城宝秀司、新出敏治、後藤範子、堀正和、中垣内正樹、牛島龍一、中村牧子、今西理恵子、服部憲明
    • Organizer
      日本心臓リハビリテーション学会第6回北陸支部地方会
    • Related Report
      2020 Research-status Report
  • [Presentation] Short-term effects of dapagliflozin versus canagliflozin on acute decompensated heart failure in patients with type 2 diabetes.2019

    • Author(s)
      Masaki Nakagaito, Shuji Joho, Ryuichi Ushijima, Makiko Nakamura, Tadakazu Hirai, Koichiro Kinugawa.
    • Organizer
      2019年ESC
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 慢性心不全における中枢性交感神経活動と体重減少との関係2019

    • Author(s)
      城宝秀司、牛島龍一、中垣内昌樹、中村牧子、絹川弘一郎
    • Organizer
      第32回日本マイクロニューログラフィー学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 慢性血栓塞栓性肺高血圧症におけるキサンチンオキシダーゼ活性の検討2019

    • Author(s)
      城宝秀司、野手姫代美、牛島龍一、中垣内昌樹、中村牧子、絹川弘一郎
    • Organizer
      第67回日本心臓病学会
    • Related Report
      2019 Research-status Report
  • [Presentation] Influence of sympathetic nerve activity on prognostic impact of anemia in patients with heart failure2019

    • Author(s)
      Shuji Joho, Ryuichi Ushijima, Masaki Nakagaito, Koichiro Kinugawa.
    • Organizer
      第83回日本循環器学会総会
    • Related Report
      2019 Research-status Report
  • [Presentation] Effect of sodium-glucose cotransporter 2 inhibitors in combination with loop diuretics on neurohumoral factor in heart failure patients with diabetes2019

    • Author(s)
      Masaki Nakagaito, Shuji Joho, Ryuichi Ushijima, Makiko Nakamura, Tadakazu Hirai, Koichiro Kinugawa.
    • Organizer
      第83回日本循環器学会総会
    • Related Report
      2019 Research-status Report
  • [Presentation] Relation between HbA1c level and effectiveness of SGLT2 inhibitors in diabetic patients with acute decompensated heart failure.2019

    • Author(s)
      Masaki Nakagaito, Shuji Joho, Ryuichi Ushijima, Makiko Nakamura, Koichiro Kinugawa.
    • Organizer
      第22回日本心不全学会
    • Related Report
      2019 Research-status Report
  • [Presentation] Is prognostic impact of hyperuricemia homogenous in patients with heart failure?2018

    • Author(s)
      Shuji Joho, Ryuichi Ushijima, Masaki Nakagaito, Makiko Nakamura, Tadakazu Hirai, Koichiro Kinugawa.
    • Organizer
      2018年ESC
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Relationship between malnutrition and sympathetic overactivation in patients with chronic heart failure.2018

    • Author(s)
      Ryuichi Ushijima, Shuji Joho, Masaki Nakagaito, Makiko Nakamura, Tadakazu Hirai, Koichiro Kinugawa.
    • Organizer
      2018年ESC
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Influence of sympathetic nerve activity on prognostic impact of anemia in patients with heart failure.2018

    • Author(s)
      Shuji Joho, Ryuichi Ushijima, Masaki Nakagaito, Koichiro Kinugawa. Influence of sympathetic nerve activity on prognostic impact of anemia in patients with heart failure. AHA annual session 2018年11月11日 シカゴ。
    • Organizer
      2018年AHA
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Relation between HbA1c level and effectiveness of SGLT2 inhibitors in diabetic patients with acute decompensated heart failure.2018

    • Author(s)
      Masaki Nakagaito, Shuji Joho, Ryuichi Ushijima, Makiko Nakamura, Tadakazu Hirai, Koichiro Kinugawa
    • Organizer
      2018年AHA
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Adaptive servo-ventilation improves GNRI and albumin level in patients with heart failure.2018

    • Author(s)
      Shuji Joho, Ryuichi Ushijima, Tadakazu Hirai, Koichiro Kinugawa.
    • Organizer
      第82回日本循環器学会総会
    • Related Report
      2018 Research-status Report
  • [Presentation] 慢性心不全における中枢性交感神経活動と体重減少との関係2018

    • Author(s)
      城宝秀司、牛島龍一、中垣内昌樹、中村牧子、絹川弘一郎
    • Organizer
      第24回日本心臓リハビリテーション学会
    • Related Report
      2018 Research-status Report
  • [Presentation] 慢性心不全における2型糖尿病による交感神経活動と予後との関係2018

    • Author(s)
      城宝秀司、牛島龍一、中垣内昌樹、中村牧子、絹川弘一郎
    • Organizer
      第66回日本心臓病学会
    • Related Report
      2018 Research-status Report
  • [Presentation] Influence of sympathetic nerve activity on prognostic impact of anemia in patients with heart failure.2018

    • Author(s)
      Shuji Joho, Ryuichi Ushijima, Masaki Nakagaito, Koichiro Kinugawa
    • Organizer
      第22回日本心不全学会
    • Related Report
      2018 Research-status Report
  • [Book] Noninvasive positive pressure ventilation. Update of Non-Pharmacological Therapy for Heart Failure (Kinugawa Koichiro, Imamura Teruhiko),2020

    • Author(s)
      Shuji Joho
    • Total Pages
      11
    • Publisher
      Springer
    • ISBN
      9789811548437
    • Related Report
      2020 Research-status Report
  • [Book] 日本臨牀 増刊号 心不全(第二版)中2019

    • Author(s)
      城宝秀司
    • Total Pages
      4
    • Publisher
      日本臨牀社
    • Related Report
      2019 Research-status Report

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Published: 2018-04-23   Modified: 2023-12-25  

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