| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
The purpose of this study was to investigate the effects of lactate on unloading-related atrophy and reloading-related regrowth of skeletal muscle. Mice were subjected to continuous hindlimb suspension for 2 weeks followed by 2-week ambulation recovery. Sodium lactate (1,000 mg/kg body weight) was orally administered to the mice. Oral administration of lactate attenuated atrophy of unloaded plantaris and soleus muscles, and decreased the phosphorylation level of 5'AMP-activated protein kinase (AMPK). Lactate administration facilitated the regrowth of reloaded plantaris muscle. Administration of lactate receptor agonist increased the muscle mass in mice and the protein content in C2C12 cells. Lactate receptor and/or the downregulation of AMPK may play a role in lactate-associated increase in skeletal muscle mass.
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