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Relationship between blood fatty acid-binding protein 4 and lipid metabolism induced by exercise

Research Project

Project/Area Number 18K10838
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 59020:Sports sciences-related
Research InstitutionNational Institute of Fitness and Sports in Kanoya

Principal Investigator

NUMAO Shigeharu  鹿屋体育大学, スポーツ生命科学系, 准教授 (90454074)

Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2020: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Keywords一過性運動 / 運動トレーニング / アディポカイン / 脂質代謝 / 一過性有酸素性運動 / 脂肪分解 / 運動強度 / 運動習慣者 / 持久系競技者 / 筋力系競技者 / 推定糸球体濾過量速度 / 血液バイオマーカー / 静脈血 / 指尖血 / 脂肪酸結合タンパク質4 / 有酸素性運動 / 血液マーカー
Outline of Final Research Achievements

Blood fatty acid-binding protein 4 (FABP4) concentration was lower in aerobic than in strength athletes. This suggests that training mode has different effects on blood FABP4 concentrations. In addition, blood FABP4 concentration did not change during acute constant-load exercise, but it increased after the end of the exercise. This suggests that some physiological factors induced by acute exercise influence the blood FABP4 concentration.

Academic Significance and Societal Importance of the Research Achievements

本研究成果は、運動に対する血中FABP4の応答を明らかにでき、FABP4の生理的役割を解明する上で有用な情報を得られたことである。一般的に血中FABP4の増加は疾患の発症と関連するが、運動中や運動後で生じる血中FABP4増加の意味はそれとは異なる生理的反応であると考えられる。今後、その意味を明らかにすることは、運動により生じる生理的適応や反応の理解に繋がるとともに、運動の新たな効果やその機序の発見にも貢献できると考えられる。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (5 results)

All 2021 2020 2019

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 3 results) Presentation (2 results)

  • [Journal Article] Differences in circulating fatty acid-binding protein 4 concentration in the venous and capillary blood immediately after acute exercise2021

    • Author(s)
      Numao Shigeharu、Uchida Ryota、Kurosaki Takashi、Nakagaichi Masaki
    • Journal Title

      Journal of Physiological Anthropology

      Volume: 40 Issue: 1 Pages: 5-5

    • DOI

      10.1186/s40101-021-00255-z

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Circulating Fatty Acid Binding Protein 4 Concentration Increases with an Acute Maximal Exercise Independently of Exercise Training Status2020

    • Author(s)
      Numao Shigeharu、Uchida Ryota、Kurosaki Takashi、Nakagaichi Masaki
    • Journal Title

      International Journal of Sport and Health Science

      Volume: 18 Issue: 0 Pages: 237-246

    • DOI

      10.5432/ijshs.202040

    • NAID

      130008024214

    • ISSN
      1348-1509, 1880-4012
    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparison of plasma fatty acid binding protein 4 concentration in venous and capillary blood2019

    • Author(s)
      Numao Shigeharu、Nagasawa Yoshinori、Goromaru Naomi、Tamaki Shunichi
    • Journal Title

      PLOS ONE

      Volume: 14 Issue: 12 Pages: e0226374-e0226374

    • DOI

      10.1371/journal.pone.0226374

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 持久系競技者と筋力系競技者における漸増負荷運動に対する血中脂肪酸結合タンパク質4の応答2020

    • Author(s)
      沼尾成晴,内田遼太,黒崎喬嗣,中垣内真樹
    • Organizer
      第75回日本体力医学会大会
    • Related Report
      2020 Research-status Report
  • [Presentation] 静脈血と指尖血の脂肪酸結合タンパク質4濃度の比較2019

    • Author(s)
      沼尾成晴、長澤吉則、五郎丸直美、田巻俊一
    • Organizer
      第74回日本体力医学会大会
    • Related Report
      2019 Research-status Report

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Published: 2018-04-23   Modified: 2023-01-30  

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