| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
To clarify the mechanism underlying atherosclerosis progression by hyperinsulinemia, we analyzed the crosstalk between insulin receptor signaling and regulatory machinery of lipid metabolism in macrophages. However, no association was observed at least in murine peritoneal exudate macrophages. Therefore, to clarify the mechanism underlying the anti-inflammatory effects of exercise, we next analyzed the effects of habitual exercise on the crosstalk between insulin receptor signaling and anti-inflammatory M2-type phenotypic polarization in macrophages. It was found that exercise promotes the enhancing effects of insulin on interleukin-4-induced M2-type phenotypic polarization of murine peritoneal exudate macrophages.
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