Exploring the mechanism of individual effect of exercise therapy

• Project/Area Number: 18K10881
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 59020:Sports sciences-related
• Research Institution: Department of Clinical Research, National Hospital Organization Kyoto Medical Center
• Principal Investigator: Domichi Masayuki 独立行政法人国立病院機構(京都医療センター臨床研究センター), 臨床研究企画運営部, 研究員 (80625046)
• Co-Investigator(Kenkyū-buntansha): 坂根 直樹 独立行政法人国立病院機構(京都医療センター臨床研究センター), 臨床研究企画運営部, 研究室長 (40335443) ; 二連木 晋輔 独立行政法人国立病院機構(京都医療センター臨床研究センター), 臨床研究企画運営部, 研究員 (70741156)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2020: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
• Keywords: 褐色脂肪組織 / サーモグラフィ / 運動 / 遺伝子多型 / 身体活動 / 個別化 / 筋力 / 褐色脂肪 / 呼気アセトン / 個人差

Outline of Final Research Achievements

We conducted as followed to examine whether brown adipose tissue is involved in individual differences of exercise therapy. We made presentations at academic conferences or papers on these achievements. 1) Devised a thermography method as a simple method for detecting brown adipose tissue activity. 2) Using the thermography method, we compared brown adipose tissue activity between people with habitual exercise. 3) Breathe acetone level in sprinter is significantly increased after cold exposure and higher than long-distance runners. 4) Investigated the relationship between the effects of exercise intervention and brown adipose-related gene polymorphisms.

Academic Significance and Societal Importance of the Research Achievements

運動療法は、生活習慣病の予防や改善に効果的であるがその効果には個人差がある。我々は、先行研究で、褐色脂肪組織 (BAT)に関連する遺伝子多型 (β3AR)が運動療法後の個人差に関連することを報告している。BATは交感神経刺激により熱産生やホルモン分泌をする組織である。しかし、BATの評価法である18FDG-PET/CT法による被曝などの制限により、運動がBATに与える影響について検討された研究は少ない。そこで、本研究では、簡易なBAT評価法の開発、および、それを用いた長期的な運動によるBATへの効果について検討を行った。本研究は、BATが運動療法による個人差の違いを説明するための一助となる。

Research Products

• [Journal Article] Social participation and physical prefrailty in older Japanese adults: The Shimane CoHRE study (2020)
  • Author(s): Abe Takafumi、Okuyama Kenta、Kamada Masamitsu、Yano Shozo、Toyama Yuta、Isomura Minoru、Nabika Toru、Sakane Naoki、Ando Hitoshi、Miyazaki Ryo
  • Journal Title: PLOS ONE Volume: 15 Issue: 12 Pages: e0243548-e0243548
  • DOI: 10.1371/journal.pone.0243548
  • Peer Reviewed / Open Access
• [Journal Article] An optimal condition for the evaluation of human brown adipose tissue by infrared thermography (2019)
  • Author(s): Nirengi Shinsuke、Wakabayashi Hitoshi、Matsushita Mami、Domichi Masayuki、Suzuki Shinichi、Sukino Shin、Suganuma Akiko、Kawaguchi Yaeko、Hashimoto Takeshi、Saito Masayuki、Sakane Naoki
  • Journal Title: PLOS ONE Volume: 14 Issue: 8 Pages: e0220574-e0220574
  • DOI: 10.1371/journal.pone.0220574
  • Peer Reviewed / Open Access
• [Journal Article] Pharmacist-Delivered Smoking Cessation Program in Community Pharmacy (The FINE Program) in Japan-The Development of a Training Course and a Feasibility Study. (2019)
  • Author(s): Onda M, Kuwanoe T, Hashimoto A, Horiguchi M, Domichi M, Sakane N.
  • Journal Title: J Pharm Pract. Volume: 34 Issue: 4 Pages: 625-630
  • DOI: 10.1177/0897190019889745
  • Peer Reviewed
• [Journal Article] Effects of a Low Advanced Glycation End Products Diet on Insulin Levels: The Feasibility of a Crossover Comparison Test. (2018)
  • Author(s): Sukino S, Nirengi S, Kawaguchi Y, Kotani K, Tsuzaki K, Okada H, Suganuma A, Sakane N.
  • Journal Title: Journal of clinical medicine research Volume: 10 Issue: 5 Pages: 405-410
  • DOI: 10.14740/jocmr3301w
  • Peer Reviewed / Open Access
• [Journal Article] Brown adipose tissue density measured by near-infrared time-resolved spectroscopy in Japanese, across a wide age range (2018)
  • Author(s): Fuse Sayuri、Nirengi Shinsuke、Amagasa Shiho、Homma Toshiyuki、Kime Ryotaro、Endo Tasuki、Sakane Naoki、Matsushita Mami、Saito Masayuki、Yoneshiro Takeshi、Kurosawa Yuko、Hamaoka Takafumi
  • Journal Title: Journal of Biomedical Optics Volume: 23 Issue: 06 Pages: 1-1
  • DOI: 10.1117/1.jbo.23.6.065002
  • Peer Reviewed / Open Access
• [Journal Article] Development and initial validation of the Morningness-Eveningness Exercise Preference Questionnaire (MEEPQ) in Japanese university students. (2018)
  • Author(s): Miyazaki R, Ando H, Hamasaki T, Higuchi Y, Oshita K, Tashiro T, Sakane N.
  • Journal Title: PLoS One. Volume: 13 Issue: 7 Pages: 1-14
  • DOI: 10.1371/journal.pone.0200870
  • Peer Reviewed / Open Access
• [Presentation] Exercise improves BAT-released signaling lipids capacity in response to cold exposure (2021)
  • Author(s): Shinsuke Nirengi, Hirokazu Taniguchi, Kengo Ishihara, Diego Hernandez-Saavedra, Masayuki Domichi, Kazuhiko Kotani, Valerie Bussberg, Michael Kiebish, Hitoshi Wakabayashi, Mami Matsushita, Masayuki Saito, Naoki Sakane, Kristin Stanford
  • Organizer: Metabolism Month 2021
  • Int'l Joint Research
• [Presentation] 大学陸上競技選手における寒冷曝露中の呼気アセトン濃度の変化 (2020)
  • Author(s): 二連木晋輔, 谷口祐一, 同道正行, 鋤納心, 竹下尚男, 石原健吾, 坂根直樹
  • Organizer: 第75回日本体力医学会学会
• [Presentation] 寒冷曝露による呼気アセトン濃度の変化 (2018)
  • Author(s): 同道正行、二連木晋輔、若林斉、松下真美 鈴木新一、竹下尚男 、河口八重子 、菅沼彰子、鋤納心 、斉藤昌之、坂根直樹
  • Organizer: 第39回日本肥満学会
• [Presentation] Effectiveness of a pharmacist-delivered smoking cessation program in community pharmacy (FINE project):A feasibility study in Japan (2018)
  • Author(s): Domichi M, Onda M, Kuwanoe T, Hashimoto A, Horiguchi M, Abe K, Suganuma A, Nirengi S, Sakane N.
  • Organizer: The 12th International Diabetes Federation Western Pacific Region Congress (IDF-WPR 2018)
  • Int'l Joint Research
• [Presentation] 個人毎の最適なエネルギー摂取やお勧めの栄養素バランスを提示する糖尿病発症予測システムの開発 機序計算モデルを用いて (2018)
  • Author(s): 坂根 直樹、Chen Julia、深澤 桃子、Chen Qian、Burns Samuel、クマール 圭、二連木 晋輔、高橋 かおる、菅沼 彰子、葛谷 英嗣、Dwivedi Gaurav
  • Organizer: 第61回 日本糖尿病学会
• [Presentation] Non-invasive evaluation of human brown adipose tissue using infrared thermography (2018)
  • Author(s): Nirengi S, Wakabayashi H, Matsushita M, Domichi M, Suzuki S, Hashimoto T, Sukino K, Suganuma A, Kawaguchi Y, Saito M, Sakane N.
  • Organizer: The 12th International Diabetes Federation Western Pacific Region Congress (IDF-WPR 2018)
  • Int'l Joint Research
• [Presentation] The impact of lifestyle intervention on stages of change toward healthy eating and development of diabetes in prediabetic individuals in precontemplation stage (2018)
  • Author(s): Sakane N, Kotani K, Nirengi S, Takahashi K, Sano Y, Okazaki K, Sato J, Suzuki S, Morita S, Oshima Y, Izumi K, Kato M, Ishizuka N, Noda M, Kuzuya H.
  • Organizer: American Diabetes Association 78th Scientific Sessions
  • Int'l Joint Research