| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
The aim of this study is to regulate the higher brain function via tryptophan metabolite kynurenic acid by control of amino acids metabolism in the peripheral. We investigated the brain and peripheral tryptophan metabolism using model animals. NASH and acute liver failure affected function of kynurenine metabolism in the astrocytes, and then enhanced kynurenic acid production from kynurenine. Partial hepatectomy increased brain kynurenic acid, whereas ulcerative colitis decreased. The mechanisms of these phenomenon are that suppression/enhancement of liver tryptophan degradation induces enhancement/ suppression of tryptophan degradation in the non-hepatic tissues, and thus brain kynurenic acid production is enhanced/suppressed. These results suggest that changes of peripheral tryptophan metabolism affect higher brain function via changes of brain kynurenic acid levels.
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