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Development of essential hypertension treatment and prevention methods applying synaptic plasticity in the carotid body

Research Project

Project/Area Number 18K10999
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 59040:Nutrition science and health science-related
Research InstitutionKokushikan University

Principal Investigator

Kusakabe Tatsumi  国士舘大学, 体育学部, 教授 (80117663)

Co-Investigator(Kenkyū-buntansha) 羽田 克彦  国士舘大学, 体育学部, 准教授 (60506228)
山本 欣郎  岩手大学, 農学部, 教授 (10252123)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords頚動脈小体 / シナプス可塑性 / 磁気刺激 / 細胞内カルシウム / 高血圧治療 / 高血圧
Outline of Final Research Achievements

'Essential hypertension', which accounts for about 90% of all hypertension cases, is high blood pressure without clearly defined etiology. Elucidation of its pathology and the development of the treatment regimen is an urgent needed in japan. Previously, we found a new association between the carotid body (CB) and hypertension. Here we focus on the the synaptic plasticity via the glutamate NMDA receptor in sensory nerve endings of CB, and develop a novel treatment method and and preventive therapy for essential hypertension to control CB using a method applying rTMS (Repetitive Transcranial Magnetic Stimulation Method). In this research, we mainly combined theoretical analysis based on computational neuroscience and experimental research.

Academic Significance and Societal Importance of the Research Achievements

我々が本研究において開発を目指す治療法は、本態性高血圧に対する世界初の非外科的・非薬物的治療であり、治療抵抗性の患者にも適用可能である。本手法は体外からCBへ反復磁気刺激を行うのみであり、薬物投与も手術も必要としない。また、ストレス等による自律神経の負荷増大(交感神経活性化と副交感神経活性低下)が高血圧や数多くの疾患の要因となる一方、有効な自律神経負荷軽減治療法は確立していない。よって本研究により新たな自律神経負荷軽減治療法や本態性高血圧予防法の開発にも繋がる可能性がある。今後色々な問題点を克服する必要はあるが本研究が進めば、高血圧治療法および予防法に新たな視点が加わることが期待される。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (7 results)

All 2020 2019

All Journal Article (4 results) (of which Peer Reviewed: 3 results,  Open Access: 2 results) Presentation (3 results)

  • [Journal Article] Multicoding in neural information transfer suggested by mathematical analysis of the frequency-dependent synaptic plasticity in vivo2020

    • Author(s)
      Hata Katsuhiko、Araki Osamu、Yokoi Osamu、Kusakabe Tatsumi、Yamamoto Yoshio、Ito Susumu、Nikuni Tetsuro
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 13974-13974

    • DOI

      10.1038/s41598-020-70876-4

    • NAID

      120007175171

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Differences in the expression of catecholamine-synthesizing enzymes between vesicular monoamine transporter 1- and 2-immunoreactive glomus cells in the rat carotid body2020

    • Author(s)
      Kato Kouki、Yokoyama Takuya、Kusakabe Tatsumi、Hata Katsuhiko、Fushuku Seigo、Nakamuta Nobuaki、Yamamoto Yoshio
    • Journal Title

      Acta Histochemica

      Volume: 122 Issue: 3 Pages: 151507-151507

    • DOI

      10.1016/j.acthis.2020.151507

    • Related Report
      2020 Annual Research Report 2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] A Brief View of the Central Nervous System with a Focus on Synaptic and Extrasynaptic Transmission2020

    • Author(s)
      Susumu Ito, Katsuhiko Hata
    • Journal Title

      EC NEUROLOGY

      Volume: 12 Pages: 54-60

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] ラット頚動脈小体への反復磁気刺激の応用による血圧変動測定の試み2020

    • Author(s)
      羽田 克彦,山本 欣郎,日下部 辰三
    • Journal Title

      国士舘大学体育研究所報

      Volume: 38 Pages: 131-132

    • NAID

      120006952628

    • Related Report
      2020 Annual Research Report
  • [Presentation] 刺激頻度依存性シナプス可塑性の数理解析から示唆された神経 情報伝達におけるマルチコーディング2020

    • Author(s)
      羽田 克彦, 日下部 辰三, 山本 欣郎, 横井 修, 二国 徹郎
    • Organizer
      第125回日本解剖学会総会・全国学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 刺激頻度依存性シナプス可塑性の数理解析から示唆された神経情報伝達におけるマルチコーディング2020

    • Author(s)
      羽田克彦、日下部 辰三、山本欣郎、横井 修、二国徹郎
    • Organizer
      125回日本解剖学会総会・全国学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] ラット頚動脈小体におけるVMAT1およびVMAT2の局在2019

    • Author(s)
      日下部辰三、加藤弘毅、横山拓矢、羽田克彦、中牟田信明、山本欣郎
    • Organizer
      第124回日本解剖学会総会・全国学術集会
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2022-01-27  

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