• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Involvement of brown adipose tissue in diurnal variations of postprandial thermogenesis and metabolism

Research Project

Project/Area Number 18K11013
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 59040:Nutrition science and health science-related
Research InstitutionHokkaido University

Principal Investigator

Saito Masayuki  北海道大学, 獣医学研究院, 名誉教授 (80036441)

Co-Investigator(Kenkyū-buntansha) 松下 真美  天使大学, 看護栄養学部, 講師 (60517316)
Project Period (FY) 2018-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords褐色脂肪組織 / 日内変動 / 食事時刻 / エネルギー消費 / 肥満 / 朝食欠食 / 食事誘導熱産生 / 寒冷誘導熱産生 / 脂肪酸酸化 / 皮膚温 / FDG-PET/CT / エネルギー代謝 / ヒト
Outline of Final Research Achievements

Disturbed circadian rhythm is associated with an increased risk of obesity and metabolic disorders. Brown adipose tissue (BAT) is a site of nonshivering thermogenesis (NST) and plays a role in regulating energy expenditure (EE) and body fatness. In this study, we examined diurnal variations of cold- and diet-induced NST in healthy humans by focusing on their relation to BAT activity. Changes in EE and BAT-related skin temperature after cold exposure in the morning were higher in a High-BAT group than in a Low-BAT group, whereas those in the evening was comparable in the two groups. Change in EE after breakfast was higher in the High-BAT group than in the Low-BAT group, whereas those after dinner was comparable in the two groups. Thus, BAT-associated NST shows diurnal variations, being higher in the morning than in the evening, and may be involved in the association of an eating habit of breakfast skipping with obesity and related metabolic disorders.

Academic Significance and Societal Importance of the Research Achievements

肥満・メタボは過食と身体活動・運動不足に起因するが、朝食欠食など、生活リズムの乱れも一因となることが知られているが、そのメカニズムは不明であった。本研究で、食事摂取後の熱産生(エネルギー消費)に関わる褐色脂肪が日内変動しており、夜に較べて朝の方が活性が高いことをヒトで初めて明らかにした。したがって、夕食よりも朝食を欠落した方が、エネルギー消費に対する影響もより大きく、長期間続くと体脂肪が蓄積されやすくなるのであろう。この成果は、褐色脂肪が活性化する朝や午前中に食事や運動を行うなど、日内リズムを踏まえた肥満・メタボの予防・改善策の指針として、社会的意義は大きいと思われる。

Report

(6 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (44 results)

All 2023 2022 2021 2020 2019 2018 Other

All Int'l Joint Research (1 results) Journal Article (23 results) (of which Int'l Joint Research: 8 results,  Peer Reviewed: 20 results,  Open Access: 20 results) Presentation (20 results) (of which Int'l Joint Research: 5 results,  Invited: 2 results)

  • [Int'l Joint Research] University of Calfornia, San Francisco(米国)

    • Related Report
      2019 Research-status Report
  • [Journal Article] Thermogenic Brown Fat in Humans: Implications in Energy Homeostasis, Obesity and Metabolic Disorders2023

    • Author(s)
      Saito Masayuki、Okamatsu-Ogura Yuko
    • Journal Title

      The World Journal of Men's Health

      Volume: 41 Issue: 3 Pages: 489-507

    • DOI

      10.5534/wjmh.220224

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] HUMAN BROWN ADIPOSE TISSUE AS A REGULATOR OF SYSTEMIC METABOLISM2022

    • Author(s)
      斉藤昌之、若林斉
    • Journal Title

      Japanese Journal of Physiological Anthropology

      Volume: 27 Issue: 2 Pages: 27-37

    • DOI

      10.20718/jjpa.27.2_27

    • ISSN
      1342-3215, 2432-0986
    • Year and Date
      2022-05-25
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Brown adipose tissue-associated postprandial thermogenesis in humans: Different effects of isocaloric meals rich in carbohydrate, fat, and protein2022

    • Author(s)
      Aita S, Matsushita M*, Yoneshiro T, Hatano T, Kameya T, Ohkubo I, Saito M
    • Journal Title

      Front Endocrinol

      Volume: 9 Pages: 1040444-1040444

    • DOI

      10.3389/fnut.2022.1040444

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Selenoprotein P-mediated reductive stress impairs cold-induced thermogenesis in brown fat2022

    • Author(s)
      Oo Swe Mar、Oo Hein Ko、Takayama Hiroaki、Ishii Kiyo-aki、Takeshita Yumie、Goto Hisanori、Nakano Yujiro、Kohno Susumu、Takahashi Chiaki、Nakamura Hiroyuki、Saito Yoshiro、Matsushita Mami、Okamatsu-Ogura Yuko、Saito Masayuki、Takamura Toshinari
    • Journal Title

      Cell Reports

      Volume: 38 Issue: 13 Pages: 110566-110566

    • DOI

      10.1016/j.celrep.2022.110566

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] ヒト褐色脂肪組織の全身代謝改善作用とそのメカニズム2022

    • Author(s)
      斉藤昌之
    • Journal Title

      医学のあゆみ

      Volume: 280 Pages: 1134-1138

    • Related Report
      2022 Annual Research Report
  • [Journal Article] Prolonged Treatment with Grains of Paradise (<i>Aframomum melegueta</i>) Extract Recruits Adaptive Thermogenesis and Reduces Body Fat in Humans with Low Brown Fat Activity2021

    • Author(s)
      YONESHIRO Takeshi、MATSUSHITA Mami、SUGITA Jun、AITA Sayuri、KAMEYA Toshimitsu、SUGIE Hiroki、SAITO Masayuki
    • Journal Title

      Journal of Nutritional Science and Vitaminology

      Volume: 67 Issue: 2 Pages: 99-104

    • DOI

      10.3177/jnsv.67.99

    • NAID

      130008031493

    • ISSN
      0301-4800, 1881-7742
    • Year and Date
      2021-04-30
    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Diurnal variations of brown fat thermogenesis and fat oxidation in humans2021

    • Author(s)
      Matsushita Mami、Nirengi Shinsuke、Hibi Masanobu、Wakabayashi Hitoshi、Lee Sang-il、Domichi Masayuki、Sakane Naoki、Saito Masayuki
    • Journal Title

      International Journal of Obesity

      Volume: 45 Issue: 11 Pages: 2499-2505

    • DOI

      10.1038/s41366-021-00927-x

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Kruppel‐like factor15 regulates fuel switching between glucose and fatty acids in brown adipocytes2021

    • Author(s)
      Nabatame Yuko、Hosooka Tetsuya、Aoki Chikako、Hosokawa Yusei、Imamori Makoto、Tamori Yoshikazu、Okamatsu‐Ogura Yuko、Yoneshiro Takeshi、Kajimura Shingo、Saito Masayuki、Ogawa Wataru
    • Journal Title

      Journal of Diabetes Investigation

      Volume: Online ahead of print Issue: 7 Pages: 1144-1151

    • DOI

      10.1111/jdi.13511

    • NAID

      120007098979

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Bacteroides spp. promotes branched-chain amino acid catabolism in brown fat and inhibits obesity2021

    • Author(s)
      Yoshida Naofumi、Yamashita Tomoya、Osone Tatsunori、Shinohara Masakazu、Kitahama Seiichi、Sasaki Kengo、Sasaki Daisuke、Emoto Takuo、Saito Yoshihiro、Kitaura Yasuyuki、Shimomura Yoshiharu、Kondo Akihiko、Kajimura Shingo、Inagaki Takeshi、Yamada Takuji、Hirata Ken-ichi
    • Journal Title

      iScience

      Volume: 24 Issue: 11 Pages: 103342-103342

    • DOI

      10.1016/j.isci.2021.103342

    • NAID

      120007179184

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Visualization of intracellular lipid metabolism in brown adipocytes by time-lapse ultra-multiplex CARS microspectroscopy with an onstage incubator2021

    • Author(s)
      Takei Yuki、Hirai Rie、Fukuda Aya、Miyazaki Shinichi、Shimada Rintaro、Okamatsu-Ogura Yuko、Saito Masayuki、Leproux Philippe、Hisatake Koji、Kano Hideaki
    • Journal Title

      The Journal of Chemical Physics

      Volume: 155 Issue: 12 Pages: 125102-125102

    • DOI

      10.1063/5.0063250

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Brown fat as a regulator of systemic metabolism beyond thermogenesis.2021

    • Author(s)
      Okamatsu-Ogura Y, Saito M
    • Journal Title

      Diabetes and Metabolism Journal

      Volume: 45 Issue: 6 Pages: 840-852

    • DOI

      10.4093/dmj.2020.0291

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 褐色脂肪組織と体温調節―ヒトでの知見を中心にー2021

    • Author(s)
      斉藤昌之
    • Journal Title

      細胞

      Volume: 53 Pages: 19-22

    • Related Report
      2021 Research-status Report
  • [Journal Article] UCP1-dependent and UCP1-independent metabolic changes induced by acute cold exposure in brown adipose tissue of mice.2020

    • Author(s)
      Okamatsu-Ogura Y, Kuroda M, Tsutsumi R, Tsubota A, Saito M, Kimura K, Sakaue H.
    • Journal Title

      Metab Clin Exp

      Volume: 113 Pages: 154396-154396

    • DOI

      10.1016/j.metabol.2020.154396

    • NAID

      120007186809

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Multiorgan contribution to non-shivering and shivering thermogenesis and vascular responses during gradual cold exposure in humans2020

    • Author(s)
      Wakabayashi Hitoshi、Matsumoto Kentaro、Kobori Yusuke、Ebara Tasuku、Matsushita Mami、Kameya Toshimitsu、Maeda Takafumi、Saito Masayuki
    • Journal Title

      European Journal of Applied Physiology

      Volume: 120 Issue: 12 Pages: 2737-2747

    • DOI

      10.1007/s00421-020-04496-1

    • NAID

      120007173919

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Brown adipose tissue, diet-induced thermogenesis, and thermogenic food ingredients: from mice to men2020

    • Author(s)
      Saito M, Matsushita M, Yoneshiro T, Okamatsu-Ogura Y
    • Journal Title

      Front Endocrinol

      Volume: 11 Pages: 222-222

    • DOI

      10.3389/fendo.2020.00222

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Applicability of supraclavicular oxygenated and total hemoglobin evaluated by near-infrared time-resolved spectroscopy as indicators of brown adipose tissue density in humans2019

    • Author(s)
      Nirengi Shinsuke、Fuse Sayuri、Amagasa Shiho、Homma Toshiyuki、Kime Ryotaro、Kuroiwa Miyuki、Endo Tasuki、Sakane Naoki、Matsushita Mami、Saito Masayuki、Kurosawa Yuko、Hamaoka Takafumi
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 20 Issue: 9 Pages: 2214-2214

    • DOI

      10.3390/ijms20092214

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] An optimal condition for the evaluation of human brown adipose tissue by infrared thermography2019

    • Author(s)
      Nirengi Shinsuke、Wakabayashi Hitoshi、Matsushita Mami、Domichi Masayuki、Suzuki Shinichi、Sukino Shin、Suganuma Akiko、Kawaguchi Yaeko、Hashimoto Takeshi、Saito Masayuki、Sakane Naoki
    • Journal Title

      PLOS ONE

      Volume: 14 Issue: 8 Pages: e0220574-e0220574

    • DOI

      10.1371/journal.pone.0220574

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] BCAA catabolism in brown fat controls energy homeostasis through SLC25A442019

    • Author(s)
      Yoneshiro T, Wang Q, Tajima K, Matsushita M, Maki H, Igarashi K, Dai Z, White P J, McGarrah R W, Ilkayeva O R, Deleye Y, Oguri Y, Kuroda M, Ikeda K, Li H, Ueno A, Ohishi M, Ishikawa T, Kim K, Chen Y, Sponton C H, Pradhan R N, Majd H, Greiner V J, Yoneshiro M, Brown Z, Chondronikola M, Takahashi H, Goto T, et al
    • Journal Title

      Nature

      Volume: 572 Issue: 7771 Pages: 614-619

    • DOI

      10.1038/s41586-019-1503-x

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association of circulating exosomal miR-122 levels with BAT activity in healthy humans2019

    • Author(s)
      Okamatsu-Ogura Yuko、Matsushita Mami、Bariuan Jussiaea Valente、Nagaya Kazuki、Tsubota Ayumi、Saito Masayuki
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 13243-13243

    • DOI

      10.1038/s41598-019-49754-1

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 褐色脂肪組織による熱産生と体温・体脂肪調節―健常成人での最新知見―2019

    • Author(s)
      斉藤昌之
    • Journal Title

      繊維製品消費科学会誌

      Volume: 60 Pages: 47-51

    • NAID

      130007556900

    • Related Report
      2019 Research-status Report 2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Brown adipose tissue density measured by near-infrared time-resolved spectroscopy in Japanese, across a wide age range2018

    • Author(s)
      Fuse Sayuri、Nirengi Shinsuke、Amagasa Shiho、Homma Toshiyuki、Kime Ryotaro、Endo Tasuki、Sakane Naoki、Matsushita Mami、Saito Masayuki、Yoneshiro Takeshi、Kurosawa Yuko、Hamaoka Takafumi
    • Journal Title

      Journal of Biomedical Optics

      Volume: 23 Issue: 6 Pages: 1-1

    • DOI

      10.1117/1.jbo.23.6.065002

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Translational Aspects of Brown Fat Activation by Food-Derived Stimulants2018

    • Author(s)
      Yoneshiro Takeshi、Matsushita Mami、Saito Masayuki
    • Journal Title

      Handbook of Experimental Pharmacology

      Volume: 251 Pages: 359-379

    • DOI

      10.1007/164_2018_159

    • ISBN
      9783030105129, 9783030105136
    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 抗肥満ターゲットとしての褐色脂肪組織と茶カテキンの効果2018

    • Author(s)
      斉藤昌之
    • Journal Title

      ファインケミカル

      Volume: 47 Pages: 11-19

    • Related Report
      2018 Research-status Report
    • Open Access
  • [Presentation] Human brown fat: a tissue preventive against obesity and metabolic diseases2022

    • Author(s)
      Saito Masayuki
    • Organizer
      22nd International Congress of Nutrition, Tokyo
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ヒト褐色脂肪組織と妊娠前の親の寒冷曝露:FDG-PETとNIR-TRSでの評価2022

    • Author(s)
      米代武司,松下真美,布施沙由理,黒岩美幸,黒澤裕子,山本恭子,飯田誠,隈健一,中村尚,浜岡隆文,酒井寿郎,斉藤昌之
    • Organizer
      第43回日本肥満学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] ヒト褐色脂肪組織と妊娠前の親の寒冷曝露:非震え熱産生からの評価2022

    • Author(s)
      松下真美、会田さゆり、米代武司、斉藤昌之
    • Organizer
      第43回日本肥満学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] β2-AR、β3-AR および UCP1 遺伝子多型がヒ トの褐色脂肪組織活性に及ぼす影2022

    • Author(s)
      石田 悠華、松下 真美、米代 武司、斉藤 昌之、 布施沙由理、浜岡 隆文、西村 貴孝、本井 碧、 前田 享史、中山 一大
    • Organizer
      第43回日本肥満学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] マウス褐色脂肪組織において寒冷刺激により誘導されるUCP1依存的および非依存的代謝変化2021

    • Author(s)
      岡松優子、黒田雅士、堤理恵、坪田あゆみ、斉藤昌之、木村和弘、坂上浩
    • Organizer
      第41回日本肥満学会
    • Related Report
      2021 Research-status Report 2020 Research-status Report
  • [Presentation] 米代武司1, 松下真美2, 梶村真吾3, 斉藤昌之2021

    • Author(s)
      米代武司, 松下真美, 梶村真吾, 斉藤昌之
    • Organizer
      第75回日本栄養・食糧学会大会
    • Related Report
      2021 Research-status Report
  • [Presentation] メバロン酸合成経路による褐色脂肪細胞分化調節機構の検討2021

    • Author(s)
      ungin Kwon、Yu-Sheng Yeh、川原崎 聡子、南野 寛人、藤田 義人、岡松 優子、野村 亘、高橋 春弥、木村 和弘、斉藤 昌之、稲垣 暢也、井上 和生、河田 照雄、後藤 剛
    • Organizer
      第75回日本栄養・食糧学会大会
    • Related Report
      2021 Research-status Report
  • [Presentation] 温熱的中立環境におけるメンソール溶液塗布による代謝亢進と褐色脂肪組織活性の関係2021

    • Author(s)
      若林斉,三浦愛子,北樹乃,藤本知臣,前田享史,亀谷俊満,松下真美,斉藤昌之
    • Organizer
      76回日本体力医学会
    • Related Report
      2021 Research-status Report
  • [Presentation] 燃える褐色脂肪組織 ―成人での最新知見と今後の課題―2021

    • Author(s)
      斉藤昌之
    • Organizer
      第27回医用近赤外線分光法研究会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] 食後熱産生に対する食事脂肪の影響と褐色脂肪の関与2020

    • Author(s)
      松下真美、斉藤昌之
    • Organizer
      第74回日本栄養・食糧学会大会
    • Related Report
      2020 Research-status Report
  • [Presentation] ヒト褐色脂肪組織活性の日内変動と病態生理学的意義2019

    • Author(s)
      斉藤昌之、松下真美、二連木晋輔、坂根直樹、李相逸、若林斉
    • Organizer
      第6回時間栄養科学研究かい
    • Related Report
      2019 Research-status Report
  • [Presentation] ヒト褐色脂肪組織の活性は日内変動する2019

    • Author(s)
      松下真美、二連木晋輔、若林斉、坂根直樹、斉藤昌之
    • Organizer
      第40回日本肥満学会
    • Related Report
      2019 Research-status Report
  • [Presentation] ヒト褐色脂肪組織と誕生季節: エピジェネティック制御の可能性2019

    • Author(s)
      斉藤昌之、松下真美、米代武司、岡松優子
    • Organizer
      第40回日本肥満学会
    • Related Report
      2019 Research-status Report
  • [Presentation] MULTIPLE ORGANS COORDINATION FOR NON-SHIVERING AND SHIVERING THERMOGENESIS AND VASOMOTOR CONTROL IN COLD ENVIRONMENT2019

    • Author(s)
      K Matsumoto1, Y Kobori, H Wakabayashi, T Kameya, M Matsushita, T Maeda, M Saito
    • Organizer
      14th International Congress of Physiological Anthropology ...
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] GENOME WIDE SCANNING FOR LOCI INFLUENCING BROWN ADIPOSE TISSUE ACTIVITY IN JAPANESE ADULTS2019

    • Author(s)
      K Nakayama, Y Sato, M Matsushita, M Saito
    • Organizer
      14th International Congress of Physiological Anthropology ...
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 軽度寒冷暴露時の非震え代謝に見られる臓器連関の検討2018

    • Author(s)
      松本健太郎、小堀祐資、若林斉、亀谷俊満、松下真美、斉藤昌之
    • Organizer
      日本生理人類学会第77回大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 赤外線サーモグラフィ法を用いた非侵襲的なヒト褐色脂肪組織の評価法の確立2018

    • Author(s)
      二連木晋輔,若林斉,松下真美,同道正行,鈴木新一,橋本健,鋤納心,菅沼彰子,河口八重子,斉藤昌之,坂根直樹
    • Organizer
      温熱生理研究会
    • Related Report
      2018 Research-status Report
  • [Presentation] 血中エクソソームmiR-122-5pはヒト褐色脂肪活性を反映するバイオマーカーとなりうる2018

    • Author(s)
      岡松優子, 松下真美, 長屋一輝, 坪田あゆみ, 斉藤 昌之
    • Organizer
      第39回日本肥満学会
    • Related Report
      2018 Research-status Report
  • [Presentation] Supraclavicular tissue total hemoglobin determined by near-infrared time-resolved spectroscopy as indicators of brown adipose tissue characteristics in humans2018

    • Author(s)
      Naoki Sakane, Mami Matsushita, Masayuki Saito, Takeshi Yoneshiro, Yuko Kurosawa
    • Organizer
      International Symposium: Role of Brown Adipose Tissue in Human Health
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Study on multiple organs coordination for non-shivering thermogenesis and vasomotor control in mild cold environment in human2018

    • Author(s)
      Kentaro Matsumoto, Yusuke Kobori, Hitoshi Wakabayashi, Mami Matsushita, Toshimitsu Kameya, Takafumi Maeda, Masayuki Saito
    • Organizer
      7th International Conference on the Physiology and Pharmacology of Temperature Regulation
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research

URL: 

Published: 2018-04-23   Modified: 2024-01-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi