Involvement of brown adipose tissue in diurnal variations of postprandial thermogenesis and metabolism
| Project/Area Number |
18K11013
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 59040:Nutrition science and health science-related
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| Research Institution | Hokkaido University |
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Principal Investigator |
Saito Masayuki 北海道大学, 獣医学研究院, 名誉教授 (80036441)
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| Co-Investigator(Kenkyū-buntansha) |
松下 真美 天使大学, 看護栄養学部, 講師 (60517316)
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| Project Period (FY) |
2018-04-01 – 2023-03-31
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| Project Status |
Completed (Fiscal Year 2022)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 褐色脂肪組織 / 日内変動 / 食事時刻 / エネルギー消費 / 肥満 / 朝食欠食 / 食事誘導熱産生 / 寒冷誘導熱産生 / 脂肪酸酸化 / 皮膚温 / FDG-PET/CT / エネルギー代謝 / ヒト |
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| Outline of Final Research Achievements |
Disturbed circadian rhythm is associated with an increased risk of obesity and metabolic disorders. Brown adipose tissue (BAT) is a site of nonshivering thermogenesis (NST) and plays a role in regulating energy expenditure (EE) and body fatness. In this study, we examined diurnal variations of cold- and diet-induced NST in healthy humans by focusing on their relation to BAT activity. Changes in EE and BAT-related skin temperature after cold exposure in the morning were higher in a High-BAT group than in a Low-BAT group, whereas those in the evening was comparable in the two groups. Change in EE after breakfast was higher in the High-BAT group than in the Low-BAT group, whereas those after dinner was comparable in the two groups. Thus, BAT-associated NST shows diurnal variations, being higher in the morning than in the evening, and may be involved in the association of an eating habit of breakfast skipping with obesity and related metabolic disorders.
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| Academic Significance and Societal Importance of the Research Achievements |
肥満・メタボは過食と身体活動・運動不足に起因するが、朝食欠食など、生活リズムの乱れも一因となることが知られているが、そのメカニズムは不明であった。本研究で、食事摂取後の熱産生（エネルギー消費）に関わる褐色脂肪が日内変動しており、夜に較べて朝の方が活性が高いことをヒトで初めて明らかにした。したがって、夕食よりも朝食を欠落した方が、エネルギー消費に対する影響もより大きく、長期間続くと体脂肪が蓄積されやすくなるのであろう。この成果は、褐色脂肪が活性化する朝や午前中に食事や運動を行うなど、日内リズムを踏まえた肥満・メタボの予防・改善策の指針として、社会的意義は大きいと思われる。
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Report
(6 results)
Research Products
(44 results)
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[Journal Article] BCAA catabolism in brown fat controls energy homeostasis through SLC25A442019
Author(s)
Yoneshiro T, Wang Q, Tajima K, Matsushita M, Maki H, Igarashi K, Dai Z, White P J, McGarrah R W, Ilkayeva O R, Deleye Y, Oguri Y, Kuroda M, Ikeda K, Li H, Ueno A, Ohishi M, Ishikawa T, Kim K, Chen Y, Sponton C H, Pradhan R N, Majd H, Greiner V J, Yoneshiro M, Brown Z, Chondronikola M, Takahashi H, Goto T, et al
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Journal Title
Nature
Volume: 572
Issue: 7771
Pages: 614-619
DOI
Related Report
Peer Reviewed / Open Access
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