| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Outline of Final Research Achievements |
To quantify the fatty acid amides acting as a lipid mediator with high sensitivity, a quantification method that uses mass spectrometry coupled with a stable isotope dilution method was established. When quantify the fatty acid amides in mice, we observed reduced oleamide concentration of serum in LPS-induced acute inflammatory model mice. The administration of oleamide to the model mice decreased inflammatory cytokines in serum and increased survival rate. These results and the observation that the pre-treatment of the cells with oleamide reduced the production of pro-inflammatory cytokines by LPS stimulation suggest that oleamide has a possibility to exert anti-inflammatory effect.
|
