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Elucidation of metabolic syndrome prevention mechanism of decenoic acid for extending healthy life expectancy

Research Project

Project/Area Number 18K11031
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 59040:Nutrition science and health science-related
Research InstitutionTokai University

Principal Investigator

Terao Akira  東海大学, 生物学部, 教授 (10451402)

Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2021: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords褐色脂肪細胞 / ローヤルゼリー / デセン酸 / メタボリックシンドローム / 睡眠 / 老化促進モデルマウス / SAMR1 / SAMP8 / 食餌性肥満 / 抗肥満 / 睡眠の質 / ノンレム睡眠 / デカン酸 / 脱共役タンパク質
Outline of Final Research Achievements

Decanoic acid and decanoic acid are known as the active ingredients of royal jelly. In particular, decenoic acid is a component peculiar to royal jelly, and its content determines the quality of royal jelly. The metabolic syndrome improvement effect of royal jelly and protease-treated royal jelly were examined. Its effect of decanoic acid and decanoic acid, which are the active ingredients of royal jelly, were also examined. As a result, royal jelly, decanoic acid, and decanoic acid significantly improved the blood glucose and triglyceride levels as compared with the high-fat diet group. This suggests that some of the effects of royal jelly are brought about by decenoic acid and/or decanoic acid.

Academic Significance and Societal Importance of the Research Achievements

最近成人にも褐色脂肪が存在し実際に機能していることが明らかにされ、肥満やメタボリックシンドロームとの関係で大いに注目を集めている。近年、茶カテキンや唐辛子カプサイシン等の食品成分が、褐色脂肪を活性化させて熱産生を促進することが示されている。実験動物での成績と対応してヒトでも類似の効果が報告されており、褐色脂肪を活性化する食品成分の探索が進んでいる。本研究ではローヤルゼリー特有成分であるデセン酸あるいはデカン酸がメタボリックシンドローム改善効果を持つことを示し、ローヤルゼリーの作用機構の一端を明らかにすることが出来た。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (9 results)

All 2022 2021 2020 2019

All Journal Article (5 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 4 results,  Open Access: 2 results) Presentation (4 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Melanin-concentrating hormone-producing neurons in the hypothalamus regulate brown adipose tissue and thus contribute to energy expenditure.2022

    • Author(s)
      Izawa S., Yoneshiro T., Kondoh K., Nakagiri S., Okamatsu-Ogura Y., Terao A., Minokoshi Y., Yamanaka A., and Kimura K.
    • Journal Title

      J. Physiol.

      Volume: 600 Issue: 4 Pages: 815-827

    • DOI

      10.1113/jp281241

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Neural Assembly仮説2021

    • Author(s)
      寺尾 晶
    • Journal Title

      睡眠医療

      Volume: 15 Pages: 355-359

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Melinjo (Gnetum gnemon L.) seed extract rescues fragmented non-rapid eye movement sleep in mice with diet- induced obesity.2021

    • Author(s)
      Terao, A., Sato, M., Sugiura, C.
    • Journal Title

      J. Physiol. Sci.

      Volume: 71 Pages: 175-175

    • Related Report
      2021 Annual Research Report
  • [Journal Article] Salmon acyl-ghrelin increases food intake and reduces doxorubicin-induced myocardial apoptosis in rats, likely by anti-oxidative activity2021

    • Author(s)
      Kihara Minoru、Kaiya Hiroyuki、Hirai Yumi、Katayama Hidekazu、Terao Akira、Nishikawa Masazumi
    • Journal Title

      Peptides

      Volume: 137 Pages: 170471-170471

    • DOI

      10.1016/j.peptides.2020.170471

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] REM sleep?active MCH neurons are involved in forgetting hippocampus-dependent memories2019

    • Author(s)
      Izawa Shuntaro、Chowdhury Srikanta、Miyazaki Toh、Mukai Yasutaka、Ono Daisuke、Inoue Ryo、Ohmura Yu、Mizoguchi Hiroyuki、Kimura Kazuhiro、Yoshioka Mitsuhiro、Terao Akira、Kilduff Thomas S.、Yamanaka Akihiro
    • Journal Title

      Science

      Volume: 365 Issue: 6459 Pages: 1308-1313

    • DOI

      10.1126/science.aax9238

    • NAID

      120006777541

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] メリンジョは食餌性肥満マウスの 断片化した睡眠を改善する2021

    • Author(s)
      佐藤 眞士、杉浦千瑛、寺尾 晶
    • Organizer
      日本睡眠学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] メリンジョは食餌性肥満マウスの断片化した睡眠を改善する2020

    • Author(s)
      佐藤 眞士、杉浦 千瑛、寺尾 晶
    • Organizer
      日本生理学会
    • Related Report
      2020 Research-status Report
  • [Presentation] Melinjo seed extract induces uncoupling protein 1 expression in brown fat and protects mice against diet-induced obesity and insulin resistance2019

    • Author(s)
      Terao A., Yoneshiro T., Kaede R., Nagaya K. Saito M., Aoyama J., Elfeky, M., Okamatsu-Ogura Y., Kimura K.
    • Organizer
      32nd Annual Meeting of European College of Neuropsychopharmacology
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Brown adipose tissue is involved in anti-obesity effects of royal jelly in high fat diet-fed mice2019

    • Author(s)
      Terao A., Yoneshiro T., Kaede R., Nagaya K. Aoyama J., Saito M., Okamatsu-Ogura Y., Kimura
    • Organizer
      9th Federation of the Asian and Oceanian Physiological Societies Congress
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2023-01-30  

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