A new hybrid treatment with acceleration training and hydrogen for non-alcoholic fatty liver disease

• Project/Area Number: 18K11042
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 59040:Nutrition science and health science-related
• Research Institution: University of Tsukuba
• Principal Investigator: Isobe Tomonori 筑波大学, 医学医療系, 教授 (70383643)
• Co-Investigator(Kenkyū-buntansha): 正田 純一 筑波大学, 医学医療系, 教授 (90241827) ; 蕨 栄治 筑波大学, 医学医療系, 講師 (70396612) ; 岡本 嘉一 筑波大学, 医学医療系, 講師 (90420083)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 非アルコール性脂肪性肝疾患 / 水素 / 加速度訓練 / 全身振動 / 運動 / 運動耐容能 / 疲労度 / ハイブリッド治療

Outline of Final Research Achievements

The purpose of this study was to clarify that treatment by acceleration training and hydrogen water intake effectively improves the metabolism of NAFLD (nonalcoholic fatty liver disease). We aimed to (1) evaluate the effect of hydrogen water on exercise endurance capacity and (2) devise a new acceleration training program. As a result, drinking hydrogen water for four weeks or more greatly reduced the body fat percentage and significantly improved the exercise endurance capacity. In addition, the practice of the new acceleration training program devised with whole body vibration greatly improved the degree of fatigue and subjective symptoms of the obese participants with NAFLD.

Academic Significance and Societal Importance of the Research Achievements

代表者らが本研究から見出した結果は、運動を避ける傾向があるNAFLD患者でも快適に実践でき、運動習慣化に繋がる新たなNAFLD運動療法の構築に大きく貢献すると考える。また、心理面・身体面のQOL（quality of life）を維持・向上させることが期待できる。全国の病院、保健所や健康施設等で「楽しく実践でき、安全かつ効果が認められ、無理なく長続きする治療法」としての新しい加速度訓練プログラムと、運動耐容能の向上に繋がる水素水の摂取が活用されることを期待する。

Research Products

• [Journal Article] Clinical and anthropometric characteristics of non‐obese non‐alcoholic fatty liver disease subjects in Japan (2020)
  • Author(s): Shida Takashi、Oshida Natsumi、Suzuki Hideo、Okada Kosuke、Watahiki Takahisa、Oh Sechang、Kim Taeho、Isobe Tomonori、Okamoto Yoshikazu、Ariizumi Shun‐ichi、Yamamoto Masakazu、Shoda Junichi
  • Journal Title: Hepatology Research Volume: 50 Issue: 9 Pages: 1032-1046
  • DOI: 10.1111/hepr.13543
  • Peer Reviewed / Open Access
• [Journal Article] Cardiorespiratory fitness is strongly linked to metabolic syndrome among physical fitness components: a retrospective cross-sectional study (2020)
  • Author(s): Kim Bokun、Ku Minjae、Kiyoji Tanaka、Isobe Tomonori、Sakae Takeji、Oh Sechang
  • Journal Title: Journal of Physiological Anthropology Volume: 39 Issue: 1 Pages: 30-30
  • DOI: 10.1186/s40101-020-00241-x
  • Peer Reviewed / Open Access
• [Journal Article] 連載 生理検査のアーチファクト･25 -MRI検査⑤-動きのアーチファクト (2019)
  • Author(s): 高倉 有, 佐藤英介, 磯辺智範
  • Journal Title: 検査と技術 Volume: 47 Issue: 6 Pages: 704-707
  • DOI: 10.11477/mf.1543207599
  • ISSN: 0301-2611, 1882-1375
  • Year and Date: 2019-06-01
• [Journal Article] 連載 生理検査のアーチファクト･24 -MRI検査④-磁化率のアーチファクト (2019)
  • Author(s): 高倉 有, 佐藤英介, 磯辺智範
  • Journal Title: 検査と技術 Volume: 47 Issue: 5 Pages: 638-641
  • DOI: 10.11477/mf.1543207578
  • ISSN: 0301-2611, 1882-1375
  • Year and Date: 2019-05-01
• [Journal Article] 連載 生理検査のアーチファクト･23 -MRI検査③-第2の化学シフトアーチファクト (2019)
  • Author(s): 高倉 有, 佐藤英介, 磯辺智範
  • Journal Title: 検査と技術 Volume: 47 Issue: 4 Pages: 551-554
  • DOI: 10.11477/mf.1543207551
  • ISSN: 0301-2611, 1882-1375
  • Year and Date: 2019-04-01
• [Journal Article] 5． A Path to the Metabolite Quantification with MR Spectroscopy (2019)
  • Author(s): 磯辺智範，只野喜一，高倉有，佐藤英介
  • Journal Title: Japanese Journal of Radiological Technology Volume: 75 Issue: 8 Pages: 832-838
  • DOI: 10.6009/jjrt.2019_JSRT_75.8.832
  • NAID: 130007691424
  • ISSN: 0369-4305, 1881-4883
  • Peer Reviewed
• [Journal Article] General ion recombination effect in a liquid ionization chamber in high-dose-rate pulsed photon and electron beams (2018)
  • Author(s): Takei Hideyuki、Isobe Tomonori、Kitamura Nozomi、Mori Yutaro、Tomita Tetsuya、Kobayashi Daisuke、Kamizawa Satoshi、Sato Tomoharu、Sakurai Hideyuki、Sakae Takeji
  • Journal Title: Journal of Radiation Research Volume: 1 Issue: 3 Pages: 1-4
  • DOI: 10.1093/jrr/rrx088
  • NAID: 120007134046
  • Peer Reviewed / Open Access
• [Journal Article] Skeletal muscle mass to visceral fat area ratio is an important determinant affecting hepatic conditions of non-alcoholic fatty liver disease (2017)
  • Author(s): Shida Takashi、Akiyama Kentaro、Oh Sechang、Sawai Akemi、Isobe Tomonori、Okamoto Yoshikazu、Ishige Kazunori、Mizokami Yuji、Yamagata Kenji、Onizawa Kojiro、Tanaka Hironori、Iijima Hiroko、Shoda Junichi
  • Journal Title: J Gastroenterol Volume: 53 Issue: 4 Pages: 535-547
  • DOI: 10.1007/s00535-017-1377-3
  • Peer Reviewed / Open Access
• [Presentation] 水素水による抗酸化能の増大が運動耐容能に与える影響 (2021)
  • Author(s): 高倉 有，西野 遼，平野伸一，早川瑠璃子，呉 世昶，森 祐太郎，磯辺智範，榮 武二
  • Organizer: 第28回日本運動生理学会大会
• [Presentation] Anti-steatosis and fibrosis effect is a weight loss-independent benefit of regular exercise on NAFLD: a retrospective study (2020)
  • Author(s): Sechang Oh, Bokun Kim, Tomonori Isobe, Takeji Sakae, Junichi Shoda
  • Organizer: 2020 International Congress on Obesity and Metabolic Syndrome (ICOMES) meeting (Virtual Congress)
  • Int'l Joint Research
• [Presentation] Molecular hydrogen improves exercise endurance capacity in mice (2020)
  • Author(s): Yu Takakura, Ryo Nishino, Ruriko Hayakawa, Sechang Oh, Takeji Sakae, Ikuru Miura, Junichi Shoda, Tomonori Isobe
  • Organizer: 2020 International Congress on Obesity and Metabolic Syndrome (ICOMES) meeting (Virtual Congress)
  • Int'l Joint Research
• [Presentation] Decreased cardiorespiratory fitness is strongly associated with metabolic syndrome: A cross-sectional study (2020)
  • Author(s): Bokun Kim, Sechang Oh, Tomonori Isobe, Takeji Sakae
  • Organizer: 2020 International Congress on Obesity and Metabolic Syndrome (ICOMES) meeting (Virtual Congress)
  • Int'l Joint Research
• [Presentation] 放射線診断物理学 (2019)
  • Author(s): 磯辺智範
  • Organizer: 2019年度医学物理士認定試験記述式問題対策講習会
  • Invited
• [Presentation] 放射線の人体への影響 －エビデンスから探る放射線健康リスク－ (2018)
  • Author(s): 磯辺智範
  • Organizer: 日本放射線技術学会
  • Invited
• [Book] 若葉マークの画像解剖学 改訂第3版（MRS） (2019)
  • Author(s): 磯辺智範、只野喜一
  • Total Pages: 761
  • Publisher: メジカルビュー社（東京）
  • ISBN: 9784758319300
• [Book] 放射線物理学（波動） (2019)
  • Author(s): 磯辺智範、榮武二、遠藤真広
  • Total Pages: 284
  • Publisher: 国際文献社
  • ISBN: 9784902590869
• [Book] MR・超音波・眼底 基礎知識図解ノート 第2版 (2018)
  • Author(s): 磯辺智範、佐藤英介、佐藤広崇、平野雄二、髙田健太、富田哲也、森 祐太郎、南木 融
  • Total Pages: 566
  • Publisher: 金原出版株式会社
  • ISBN: 9784307071079