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A New development in the interventions for childhood metabolic syndrome from the incretin pathway

Research Project

Project/Area Number 18K11045
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 59040:Nutrition science and health science-related
Research InstitutionTottori University

Principal Investigator

HANAKI Keiichi  鳥取大学, 医学部, 特任教授 (20238041)

Co-Investigator(Kenkyū-buntansha) 神崎 晋  鳥取大学, 医学部, 教授 (90224873)
Project Period (FY) 2018-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords小児肥満 / メタボリックシンドローム / メタボリック症候群 / 肥満 / インクレチン / 膵外作用
Outline of Final Research Achievements

Addressing childhood obesity and metabolic syndrome at an early age and reducing the transition to adulthood is essential to reduce lifestyle-related diseases in adulthood. In this study, data on the prevalence of childhood obesity presented in published databases and scientific meetings were collected for the stratified age group of 6-18 years. As the incidence of childhood obesity is highest around 11-12 years for boys and 15 years for girls, while the incidence of childhood metabolic syndrome is reported to be 0.5-1%, it was considered more appropriate as an intervention to assess food preferences, including both obese children and those with metabolic syndrome. The sharp increase in the prevalence of obesity in 11-14 year old boys and girls due to the coronavirus catastrophe deepens the significance of this study.

Academic Significance and Societal Importance of the Research Achievements

成人期の生活習慣病を減らすためには、小児期の肥満やメタボリック症候群へ早期から対応し、成人期への移行を減らすことが肝要である。データベースより小児肥満頻度を6~18歳の階層別データとして集積した。小児肥満の頻度は、男子では11~12歳頃に、女子では15歳頃に最高値となる一方、小児期メタボリックシンドロームの頻度は0.5~1%と報告されていることから、メタボリックシンドロームに限らず肥満小児を含めて食物嗜好を評価する方が介入として適切であると考えられた。

Report

(7 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (28 results)

All 2024 2023 2022 2021 2020 2019 2018

All Journal Article (10 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 4 results,  Open Access: 4 results) Presentation (13 results) (of which Int'l Joint Research: 2 results,  Invited: 2 results) Book (5 results)

  • [Journal Article] 小児期の肥満・肥満症への対応: 成人肥満への持ち越しを防ぐために2022

    • Author(s)
      花木啓一
    • Journal Title

      臨床栄養

      Volume: 141 Pages: 290-297

    • Related Report
      2022 Research-status Report
  • [Journal Article] 肥満・やせ2021

    • Author(s)
      花木啓一
    • Journal Title

      小児科診療

      Volume: 84(7) Pages: 935-940

    • Related Report
      2021 Research-status Report
  • [Journal Article] 小児肥満の特徴と対策2021

    • Author(s)
      花木啓一、藤本正伸
    • Journal Title

      Medical Practice

      Volume: 38(7) Pages: 1001-1006

    • Related Report
      2021 Research-status Report
  • [Journal Article] 小児における栄養評価方法2021

    • Author(s)
      花木啓一
    • Journal Title

      小児内科

      Volume: 53(11) Pages: 1830-1838

    • Related Report
      2021 Research-status Report
  • [Journal Article] 小児期の生活習慣病とその危険因子:コロナ後の社会における健康的な生活習慣とは2021

    • Author(s)
      花木啓一
    • Journal Title

      日本医師会雑誌

      Volume: 150(6) Pages: 1044-1046

    • Related Report
      2021 Research-status Report
  • [Journal Article] 小児の食事嗜好と体格指標の関連 タッチパネルを用いた食品イラスト画選択法による評価の試み2020

    • Author(s)
      木村 真司, 福岡 理英, 南前 恵子, 花木 啓一
    • Journal Title

      肥満研究

      Volume: 26 Pages: 348-356

    • NAID

      40022474116

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of a Self-efficacy Theory–Based Training Program for Peers of Patients with Type 2 Diabetes2020

    • Author(s)
      Tanimura C, Aoto H, Kobayashi N, Majbauddin A, Morita T, Otani S, Inoue K, Tokushima Y, Fukada M, Hanaki K, Sakai C, Okura T, Kageyama S, Kurozawa Y, Flores R, Raymundo R.
    • Journal Title

      Yonago Acta Medica

      Volume: 63 Issue: 4 Pages: 282-293

    • DOI

      10.33160/yam.2020.11.006

    • NAID

      130007942207

    • ISSN
      0513-5710, 1346-8049
    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A Randomized Placebo-controlled Trial of an Oral Preparation of High Molecular Weight Fucoidan in Patients with Type 2 Diabetes with Evaluation of Taste Sensitivity.2019

    • Author(s)
      Sakai C, Abe S, Kouzuki M, Shimohiro H, Ota Y, Sakinada H, Takeuchi T, Okura T, Kasagi T, Hanaki K.
    • Journal Title

      Yonago Acta Med

      Volume: 62(1) Pages: 14-23

    • NAID

      130007626269

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Conceptual Model for Quality of Life Among People with Type 2 Diabetes in the Philippines.2019

    • Author(s)
      Aoto H, Tanimura C, Majbauddin A, Kobayashi N, Morita T, Inoue K, Otani S, Fukada M, Hanaki K.
    • Journal Title

      Yonago Acta Med

      Volume: 62(1) Pages: 53-61

    • NAID

      130007626302

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 成人での肥満予防を見据えた、介入に適した年齢層での比較試験が必要2018

    • Author(s)
      花木啓一
    • Journal Title

      MMJ The Mainichi Medical Journal

      Volume: 14(3) Pages: 93-93

    • Related Report
      2018 Research-status Report
  • [Presentation] イラスト選択法と質問紙法を用いた 小児の運動性向と運動関連生活習慣の評価2023

    • Author(s)
      木村真司, 福岡理英, 花木啓一
    • Organizer
      第43回日本看護科学会学術集会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Reciprocal relationships between cord blood levels of PAPP-A2, IGF-1, and IGFBPs and anthropometry data in newborns.2021

    • Author(s)
      Masanobu Fujimoto, Shintaro Senoo, Hiromi Fujii, Akiko Hasegawa, Fumiko Miyahara, Yoichi Mino, Mazumi Miura, Keiichi Hanaki, Noriyuki Namba
    • Organizer
      11th Asia Pacific Paediatric Endocrine Society (APPES) Biennial Scientific Meeting
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] イラスト選択法による学童期の運動性向と食物嗜好の評価2021

    • Author(s)
      木村真司、福岡理英、花木啓一
    • Organizer
      第42回日本肥満学会学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] 外遊び指向・運動習慣・運動性向の3指標による小児の身体活動量評価2021

    • Author(s)
      木村真司、福岡理英、花木啓一
    • Organizer
      第68回小児保健協会学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] 小児期の生活習慣病とその危険因子2021

    • Author(s)
      花木啓一
    • Organizer
      令和3年度学校保健講習会
    • Related Report
      2021 Research-status Report
  • [Presentation] 当院における2歳未満発症の1型糖尿病4例の検討2020

    • Author(s)
      妹尾 慎太郎, 山口 由起子, 西村 玲, 鞁嶋 有紀, 花木 啓一
    • Organizer
      第124回日本小児科学会学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] イラスト画タッチパネル法による小児期の食物嗜好の評価 市部と中山間地の比較2020

    • Author(s)
      木村 真司, 福岡 理英, 南前 恵子, 花木 啓一
    • Organizer
      第67回日本小児保健協会学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] 小児版生活習慣質問紙を用いた市部・中山間地肥満小児の食事・運動習慣の比較2019

    • Author(s)
      木村真司、福岡理英、南前恵子、花木啓一
    • Organizer
      第40回日本肥満学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] フィリピンにおける小児の食習慣に関する質問紙調査2019

    • Author(s)
      青戸春香、永久武志、両見知将、谷村千華、小林伸行、Abir Majbauddin、森田鉄二、徳嶋靖子、深田美香、大谷眞二、井上和興、金山俊介、花木啓一
    • Organizer
      第66回 日本小児保健協会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] 肥満小児の食事への関心・嗜好の地域差の検討: 新しい食行動評価方法を用いて2019

    • Author(s)
      木村真司、福岡理英、赤井研樹、遠藤有里、南前恵子、花木啓一
    • Organizer
      第66回 日本小児保健協会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] Rural-Urban Differences in Eating and Exercise Habits among Children with Obesity: an Evaluation by Using a Self-report Questionnaire Validated by a Factor Analysis2019

    • Author(s)
      Kimura S, Fukuoka R, Minamimae K, Hanaki K
    • Organizer
      2019 International Congress on Obesity and Metabolic Syndrome & Asia-Oceania Conference on Obesity
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 小児の視点から見た肥満診療と肥満症2018

    • Author(s)
      花木啓一
    • Organizer
      第39回日本肥満学会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 小児肥満と日本人の生活習慣2018

    • Author(s)
      花木啓一
    • Organizer
      第32回日本小児脂質研究会学術集会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Book] 小児・思春期糖尿病コンセンサス・ガイドライン20242024

    • Author(s)
      花木啓一
    • Total Pages
      116
    • Publisher
      南江堂
    • Related Report
      2023 Annual Research Report
  • [Book] 小児科診療ガイドライン2023

    • Author(s)
      花木啓一、長石純一、神﨑晋
    • Total Pages
      834
    • Publisher
      総合医学社
    • ISBN
      9784883784707
    • Related Report
      2022 Research-status Report
  • [Book] 今日の治療指針20212021

    • Author(s)
      花木啓一
    • Total Pages
      2151
    • Publisher
      医学書院
    • Related Report
      2020 Research-status Report
  • [Book] 今日の小児治療指針 vol172020

    • Author(s)
      花木啓一
    • Total Pages
      980
    • Publisher
      医学書院
    • Related Report
      2020 Research-status Report
  • [Book] 今日の診断指針第8版2020

    • Author(s)
      花木啓一
    • Total Pages
      2112
    • Publisher
      医学書院
    • ISBN
      9784260038089
    • Related Report
      2019 Research-status Report

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Published: 2018-04-23   Modified: 2025-01-30  

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