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The study on relationships between CLOCK gene polymorphism and childhood obesity

Research Project

Project/Area Number 18K11052
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 59040:Nutrition science and health science-related
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

Nakajima Hisakazu  京都府立医科大学, 医学(系)研究科(研究院), 講師 (80363985)

Co-Investigator(Kenkyū-buntansha) 森 潤  京都府立医科大学, 医学(系)研究科(研究院), 助教 (20750011)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords小児肥満 / 時計遺伝子 / 概日リズム / 遺伝子多型 / CLOCK遺伝子 / 生体リズム / CLOCK / BMAL / 生活習慣
Outline of Final Research Achievements

In this study, we investigated whether the CLOCK gene SNPs could influence the prevalence of childhood obesity and overweight, and obesity-related comorbidities in a school-aged Japanese population. Participants were 271 non-obese school-aged subjects and 71 children with obesity or overweight. Anthropometric data, fasted blood sugar, fasted serum insulin, hemoglobin A1c, serum total cholesterol, LDL-cholesterol, HDL-cholesterol and triglycerides were measured on each participant. We selected 3 SNPs of CLOCK gene as follows: rs1801260 (3111T/C), rs1464490 and rs3749474, which were genotyped on all the participants by TaqMan probe method. We did not identify that these SNPs of CLOCK gene were associated with increased or lower incidence of childhood obesity with estimating the odds ratios with chi-square test. Additionally, we found no relationships between obesity-related comorbidities (severe obesity, hyperglycemia, insulin resistance and dyslipidemia) and the current 3 SNPs of CLOCK.

Academic Significance and Societal Importance of the Research Achievements

小児肥満の出現や合併症を含む表現型に対して、CLOCK遺伝子のSNPsが及ぼす影響は極めて少ないと考えられた。成人のような夜型シフトワーカーの生活習慣をもつことは小児ではほどんどないため、概日リズムを調節する遺伝子多型のような遺伝学背景が及ぼす影響は極めて限定的かもしれない。概日リズムの形成に必須の遺伝子はCLOCK遺伝子以外のものも知られるので、今後、時間遺伝子の種類の範囲を広げ、それぞれの遺伝子が与えるインパクトを検討する必要がある。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (21 results)

All 2020 2019 2018

All Journal Article (13 results) (of which Peer Reviewed: 13 results,  Open Access: 11 results) Presentation (8 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] An infantile case of pseudohypoaldosteronism type 1 (PHA1) caused by a novel mutation of <i>NR3C2</i>2020

    • Author(s)
      Goda Takeshi, Komatsu Hiroshi, Nozu Kandai, Nakajima Hisakazu
    • Journal Title

      Clinical Pediatric Endocrinology

      Volume: 29 Issue: 3 Pages: 127-130

    • DOI

      10.1297/cpe.29.127

    • NAID

      130007872512

    • ISSN
      0918-5739, 1347-7358
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Case of Caesarean Section for Pregnancy with COVID-192020

    • Author(s)
      青山 幸平、黒星 晴夫、中島 久和、中川 憲夫、山下 優、渡邉 亜矢、北脇 城
    • Journal Title

      Journal of Japan Society of Perinatal and Neonatal Medicine

      Volume: 56 Issue: 3 Pages: 527-532

    • DOI

      10.34456/jjspnm.56.3_527

    • NAID

      130007952990

    • ISSN
      1348-964X, 2435-4996
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 骨折既往のある重症心身障害児(者)の臨床像と骨代謝マーカー(尿中I型コラーゲン架橋N末端テロペプチド)との関連性の後方視的検討2020

    • Author(s)
      中島久和、松井史裕、寺田直人
    • Journal Title

      京都府立医科大学附属北部医療センター雑誌

      Volume: 6 Pages: 20-28

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Aging-associated impairment in metabolic compensation by subcutaneous adipose tissue promotes diet-induced fatty liver disease in mice2019

    • Author(s)
      Taketani Hiroyoshi、Nishikawa Tichiro、Nakajima Hisakazu、Kodo Kazuki、Sugimoto Satoru、Aoi Wataru、 Horike Shin-Ichi、 Meguro-Horike Makiko、 Ishiba Hiroshi、 Seko Yuya、Umemura Atsushi、 Yamaguchi Kanji、Moriguchi Michihisa、 Yasui Kohichiroh、 Itoh Yoshito.
    • Journal Title

      Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy

      Volume: 12 Pages: 1473-1492

    • DOI

      10.2147/dmso.s214093

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pituitary apoplexy after cardiac surgery in a 14-year-old girl with Carney complex: a case report2019

    • Author(s)
      Naito Yuki、Mori Jun、Tazoe Jun、Tomida Akimasa、Yagyu Shigeki、Nakajima Hisakazu、Iehara Tomoko、Tatsuzawa Kazunori、Mukai Tokuo、Hosoi Hajime
    • Journal Title

      Endocrine Journal

      Volume: 66 Issue: 12 Pages: 1117-1123

    • DOI

      10.1507/endocrj.EJ19-0183

    • NAID

      130007772418

    • ISSN
      0918-8959, 1348-4540
    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] ACE2 exerts anti-obesity effect via stimulating brown adipose tissue and induction of browning in white adipose tissue2019

    • Author(s)
      Kawabe Yasuhiro、Mori Jun、Morimoto Hidechika、Yamaguchi Mihoko、Miyagaki Satoshi、Ota Takeshi、Tsuma Yusuke、Fukuhara Shota、Nakajima Hisakazu、Oudit Gavin Y.、Hosoi Hajime
    • Journal Title

      American Journal of Physiology-Endocrinology and Metabolism

      Volume: 317 Issue: 6 Pages: E1140-E1149

    • DOI

      10.1152/ajpendo.00311.2019

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A case of pseudohypoparathyroidism type Ia with a novel frameshift mutation in the <i>GNAS</i> gene: early diagnosis of osteoma cutis by skin biopsy2019

    • Author(s)
      Kodo Kazuki、Maeda Hiroshi、Morimoto Hidechika、Wada Makoto、Imura Tetsuya、Nakajima Hisakazu
    • Journal Title

      Clinical Pediatric Endocrinology

      Volume: 28 Issue: 1 Pages: 15-18

    • DOI

      10.1297/cpe.28.15

    • NAID

      130007584686

    • ISSN
      0918-5739, 1347-7358
    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A pediatric case of hypomagnesemia 1 (HOMG1) caused by novel compound heterozygous mutations in TRPM62019

    • Author(s)
      Goda Takeshi、Komatsu Hiroshi、Nozu Kandai、Nakajima Hisakazu
    • Journal Title

      Human Genome Variation

      Volume: 6 Issue: 1 Pages: 13-13

    • DOI

      10.1038/s41439-019-0043-0

    • NAID

      120006644104

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Erythropoietin and long-acting erythropoiesis stimulating agent ameliorate non-alcoholic fatty liver disease by increasing lipolysis and?decreasing lipogenesis via EPOR/STAT pathway2019

    • Author(s)
      Tsuma Yusuke、Mori Jun、Ota Takeshi、Kawabe Yasuhiro、Morimoto Hidechika、Fukuhara Shota、Kodo Kazuki、Umemura Atsushi、Nakajima Hisakazu、Hosoi Hajime
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 509 Issue: 1 Pages: 306-313

    • DOI

      10.1016/j.bbrc.2018.12.131

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] High-fat diet accelerates extreme obesity with hyperphagia in female heterozygous Mecp2-null mice2019

    • Author(s)
      Fukuhara Shota、Nakajima Hisakazu、Sugimoto Satoru、Kodo Kazuki、Shigehara Keiichi、Morimoto Hidechika、Tsuma Yusuke、Moroto Masaharu、Mori Jun、Kosaka Kitaro、Morimoto Masafumi、Hosoi Hajime
    • Journal Title

      PLOS ONE

      Volume: 14 Issue: 1 Pages: e0210184-e0210184

    • DOI

      10.1371/journal.pone.0210184

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 骨脆弱性を伴う重症心身障害児(者)に対する経口アレンドロネートの長期投与の検討2018

    • Author(s)
      岡本侑子, 松井史裕, 永井秀之, 神谷康隆, 寺田直人, 中島久和
    • Journal Title

      日本重症心身障害学会雑誌

      Volume: 43 Pages: 129-136

    • NAID

      130007850359

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] 横紋筋融解症の急性腎障害を念頭に早期介入を行った慢性甲状腺炎の1女児例2018

    • Author(s)
      宮垣知史, 幸道和樹, 伊藤育世, 中島久和, 細井創
    • Journal Title

      小児科臨床

      Volume: 71 Pages: 1394-8

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Decrement in bone mineral density after parathyroidectomy in a pediatric patient with primary hyperparathyroidism2018

    • Author(s)
      Morimoto Hidechika、Nakajima Hisakazu、Mori Jun、Fukuhara Shota、Shigehara Keiichi、Adachi Shinsuke、Hosoi Hajime
    • Journal Title

      Clinical Pediatric Endocrinology

      Volume: 27 Issue: 2 Pages: 81-86

    • DOI

      10.1297/cpe.27.81

    • NAID

      130006701336

    • ISSN
      0918-5739, 1347-7358
    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 胆道閉鎖症術後に多腺性自己免疫症候群3A型を合併しHbA1c偽低値を認める症例2020

    • Author(s)
      森 潤、宮垣 知史、山口 美穂子、太田 武志、 河辺 泰宏、岡垣 雅美、古川 泰三、中島 久和
    • Organizer
      第63回日本糖尿病学会年次学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] High-fat diet accelerates extreme obesity with hyperphagia and severe glucose intolerance in female heterozygous Mecp2 null mice2019

    • Author(s)
      Fukuhara Syota, Nakajima Hisakazu, Kodo Kazuki, Morimoto Hidechika, Tsuma Yusuke, Sugimoto Satoru, Mori Jun
    • Organizer
      45th Annual Conference of ISPAD, Nov 1, 2019: Boston MA, USA
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] ACE2/Ang1-7/Mas receptorを介した褐色脂肪の活性化による抗肥満効果2019

    • Author(s)
      河辺 泰宏, 森 潤, 森元 英周, 宮垣 知史, 太田 武志, 都間 佑介, 中島 久和.
    • Organizer
      第92回日本内分泌学会学術集会. 令和元年5月10日, 仙台
    • Related Report
      2019 Research-status Report
  • [Presentation] 頭痛・全身倦怠感を主訴に診断されたGitelman症候群の姉弟例2019

    • Author(s)
      中島久和,幸道和樹,森元英周,野津寛大
    • Organizer
      第53回日本小児内分泌学会学術集会. 令和元年9月26日, 京都
    • Related Report
      2019 Research-status Report
  • [Presentation] 熱産生機構に注目したアンギオテンシン変換酵素2の抗肥満効果の検討.2019

    • Author(s)
      河辺泰宏,森潤,森元英周,都間佑介,中島久和
    • Organizer
      第40回日本肥満学会・第37回日本肥満症治療学会学術集会 合同学術集会. 令和元年11月3日, 東京
    • Related Report
      2019 Research-status Report
  • [Presentation] IGF2遺伝子変異に起因するシルバーラッセル症候群の臨床的特徴.2019

    • Author(s)
      増永陽平, 矢本香織, 才津浩智, 井上毅信, 中川憲夫, 中島久和, 長谷川龍志, 大幡泰久, 難波範行, 鞍島有紀, 佐藤恭弘, 磯島豪, 小川英伸, 山口有, 古橋博史, 森貞直哉, 飯島一誠, 栗林良多, 鈴村宏, 藤澤泰子, 鏡雅代, 深見真紀, 緒方勤
    • Organizer
      第92回日本内分泌学会学術集会. 令和元年5月10日, 仙台
    • Related Report
      2019 Research-status Report
  • [Presentation] 高脂肪食肥満マウスの非アルコール性脂肪性肝疾患(NAFLD)に対するエリスロポエチンおよび長時間作用型エリスロポエチンの投与実験2018

    • Author(s)
      都間祐介, 中島久和, 太田武志, 河辺泰宏, 森元英周, 福原正太, 森潤, 楳村敦詩,細井創.
    • Organizer
      第91回日本内分泌学会学術総会、第39回日本肥満学会
    • Related Report
      2018 Research-status Report
  • [Presentation] Ang1-7は食餌性肥満マウスの肥満・耐糖能を改善する:褐色脂肪の関与について.2018

    • Author(s)
      森元英周, 森潤, 河辺泰宏, 都間祐介, 福原正太, 幸道和樹, 茂原慶一, 中島久和, 細井創
    • Organizer
      第52回日本小児内分泌学会学術集会
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2022-01-27  

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