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Establishment of new functional food ingredients which are effective for prevention of mesothelioma due to regulation of mesothelioma stem cells

Research Project

Project/Area Number 18K11058
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 59040:Nutrition science and health science-related
Research InstitutionToyo University

Principal Investigator

Yano Tomohiro  東洋大学, 食環境科学部, 教授 (50239828)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords中皮腫幹細胞 / Tumorsphere / 薬剤耐性 / 小胞体ストレス / プロテオソーム / オートファジー / トコトリエノール誘導体 / 細胞死 / Nrf1 / アポトーシス / 幹細胞マーカー / 3次元培養 / 機能性食素材 / 中皮腫予防
Outline of Final Research Achievements

In order to evaluate if a new preventive strategy for malignant mesothelioma could be established, due to regulation of mesothelioma stem cells, I estimated suppressive effect of T3E, a stable derivative of tocotrienol which was known as a representative ingredient of anti- cancer agent, on mesothelioma stem cells, Firstly, I succeeded in the establishment of a three- dimensional culture system to concentrate on mesothelioma stem cells from parental mesothelioma cells, and subsequently, I investigated whether T3E could act as an effective agent to regulate mesothelioma stem cells. Consequently, I clearly showed that T3E could act as a potential agent to induce cell death in mesothelioma stem cells which have chemo-resistance against conventional anti- mesothelioma agents, based on simultaneous inhibition of proteasome and autophagy.

Academic Significance and Societal Importance of the Research Achievements

アスベスト暴露により発生し、発生数が増加傾向にある難治性が高い中皮腫の新規予防法の開発が急務である。本研究では、中皮腫の根本的な発症要因とされ、中皮腫の難治性の原因とされる中皮腫幹細胞に対して、代表的な食由来の安全性が高いトコトリエノールの安定化誘導体(T3E)が顕著な殺細胞効果を示し、かつ、T3Eが既存の中皮腫治療薬として用いられている抗がん剤に対する中皮腫幹細胞の薬剤耐性を軽減できることを示した。この成果は、将来的に有効な中皮腫予防法の構築につながる重要な成果といえる。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (20 results)

All 2021 2020 2019 2018 Other

All Journal Article (5 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 5 results,  Open Access: 4 results) Presentation (12 results) (of which Int'l Joint Research: 2 results) Remarks (3 results)

  • [Journal Article] 喫煙による肺発がんに対するalphaートコフェロールの抑制効果2021

    • Author(s)
      石田達也、矢野友啓
    • Journal Title

      ビタミン

      Volume: 95

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The effect of Bowman-Birk inhibitor from soybeans on the sensitivity of prostate cancer stem-like cells to anti-androgen agent2020

    • Author(s)
      Endo D, Kaneko S, Kohno S, Sato A, Nantiga V, Yano T.
    • Journal Title

      Food Science and Technology

      Volume: 26

    • NAID

      130007904094

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Combination Effect of Bowman-Birk Inhibitor and α-Tocopheryl Succinate on Prostate Cancer Stem-Like Cells2019

    • Author(s)
      Kaneko S, Yamazaki T, Kohno K, Sato A, Kato K, Yano T.
    • Journal Title

      Journal of Nutritional Science and Vitaminology

      Volume: 65 Issue: 3 Pages: 272-277

    • DOI

      10.3177/jnsv.65.272

    • NAID

      130007670195

    • ISSN
      0301-4800, 1881-7742
    • Year and Date
      2019-06-30
    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Redox-Inactive Derivative of Tocotrienol Suppresses Tumor Growth of Mesothelioma Cells in a Xenograft Model2019

    • Author(s)
      Sato A, Arai T, Fusegi M, Ando A, Yano T.
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 42 Issue: 6 Pages: 1034-1037

    • DOI

      10.1248/bpb.b18-00924

    • NAID

      130007657679

    • ISSN
      0918-6158, 1347-5215
    • Year and Date
      2019-06-01
    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Succinate Ether Derivative of Tocotrienol Enhances Dickkopf-1 Gene Expression through Epigenetic Alterations in Malignant Mesothelioma Cells2018

    • Author(s)
      Sato Ayami、Ueno Haruka、Fusegi Momoka、Kaneko Saki、Kohno Kakeru、Virgona Nantiga、Ando Akira、Sekine Yuko、Yano Tomohiro
    • Journal Title

      Pharmacology

      Volume: 102 Issue: 1-2 Pages: 26-36

    • DOI

      10.1159/000489128

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] 悪性胸膜中皮腫スフェロイドの治療抵抗性上昇は低酸素ストレスに起因するか?2021

    • Author(s)
      遠藤大輝、矢野友啓
    • Organizer
      日本薬学会第141年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 悪性中皮腫細胞株における低酸素誘導因子HIFを標的としたアナト-由来トコトリエノールの腫瘍抑制作用解析2020

    • Author(s)
      河野翔、矢野友啓
    • Organizer
      日本ビタミン学会大72回大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Can T3E overcome chemoresistance of mesothelioma cells via the inhibition of endoplasmic reticulum stress?2020

    • Author(s)
      Ishii K, Yano T
    • Organizer
      2020 annual meeting of JCA
    • Related Report
      2020 Annual Research Report
  • [Presentation] 3次元培養システムによる悪性胸膜中皮腫スフェロイドとがん幹細胞性との関連2020

    • Author(s)
      遠藤大輝、矢野友啓
    • Organizer
      2020年癌学会総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] ビタミンE同族体の悪性胸膜中皮腫細胞への影響2020

    • Author(s)
      荒井恒毅、矢野友啓
    • Organizer
      2020年癌学会総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 低酸素環境下の中皮腫細胞株を標的にしたトコトリエノールの抗がん作用解析2020

    • Author(s)
      河野翔、矢野友啓
    • Organizer
      第31回ビタミンE研究会
    • Related Report
      2020 Annual Research Report
  • [Presentation] タンパク関連メカニズムに焦点をあてたビタミンE誘導体T3Eの抗中皮腫作用の検討2020

    • Author(s)
      伏木桃花、河野翔、中野渡真奈、矢野友啓
    • Organizer
      第31回ビタミンE研究会
    • Related Report
      2019 Research-status Report
  • [Presentation] A new preventive strategy for targeting gap junction in prostate cancer stem cells2019

    • Author(s)
      Endo D, Yano T. Kaneko S, Kato K, Amano T
    • Organizer
      The International Gap Junction Conference 2019
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] T3Eは悪性中皮腫細胞の化学療法抵抗性を克服するために有効か?2019

    • Author(s)
      伏木桃花、矢野友啓
    • Organizer
      第78回日本癌学会学術総会
    • Related Report
      2019 Research-status Report
  • [Presentation] ビタミンE誘導体による遺伝子多型に基づいた悪性中皮腫細胞死耐性の克服2019

    • Author(s)
      伏木桃花、河野翔、矢野友啓
    • Organizer
      第30回ビタミンE研究会
    • Related Report
      2018 Research-status Report
  • [Presentation] MTHFR C677T SNPは小胞体ストレスを介した抗中皮腫効果に影響を及ぼすか?2018

    • Author(s)
      伏木桃花、矢野友啓
    • Organizer
      第77回 日本癌学会学術総会
    • Related Report
      2018 Research-status Report
  • [Presentation] Can MTHFR C677T SNP affect anti-mesothelioma effect via ER stress?2018

    • Author(s)
      Momoka Fusegi, Kakeru Kohno, Tomohiro Yano
    • Organizer
      Sydney Cancer Conference 2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Remarks] 東洋大学研究者情報データーベース

    • URL

      http://ris.toyo.ac.jp/profile/ja.98c14e15691e141256190968aeb7164a.html#URL

    • Related Report
      2020 Annual Research Report
  • [Remarks] 東洋大学研究者情報データーベース

    • URL

      http://ris.toyo.ac.jp/profile/ja.98c14e15691e141256190968aeb7164a.html

    • Related Report
      2019 Research-status Report
  • [Remarks] 東洋大学分子食理学研究室ホームページ

    • URL

      https://nutritionscience.web.fc2.com/

    • Related Report
      2019 Research-status Report

URL: 

Published: 2018-04-23   Modified: 2022-01-27  

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