| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
The number of diabetes patients is increasing worldwide. Although obesity prevention is important to prevent type 2 diabetes, many Japanese develop diabetes even though they are not obese. Moreover, Japanese consume fewer calories per day than their Western counterparts. While there have been many studies on the development of type 2 diabetes caused by obesity, there have been only a few studies on non-obese type 2 diabetes. In this study, we investigated the mechanism of the development of non-obese type 2 diabetes using mice. We found that excessive intake drink containing high fructose corn syrup with controlled daily energy intake induced impaired glucose tolerance without body weight gain. The mechanism differed by age.
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