Molecular mechanism in the brain of the change in food preference associated with rapid weight loss after obesity
| Project/Area Number |
18K11079
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 59040:Nutrition science and health science-related
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| Research Institution | University of the Ryukyus |
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Principal Investigator |
Okamoto Shiki 琉球大学, 医学(系)研究科(研究院), 助教 (40342919)
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| Co-Investigator(Kenkyū-buntansha) |
益崎 裕章 琉球大学, 医学(系)研究科(研究院), 教授 (00291899)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 炭水化物嗜好性 / CRH / 肥満 / リバウンド / 食嗜好性 / 減量 |
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| Outline of Final Research Achievements |
It is well known that rapid weight loss is accompanied by picky eating and abnormal eating behavior, which may lead to a rebound, but detailed molecular mechanisms in the brain remain unclear. In the present study, we focused on changes in food preference and analyzed the mechanisms that regulate abnormal eating behavior in the hypothalamus during different periods of weight change. In the post-obesity weight-loss mice (WL), fat intake increased in addition to carbohydrate intake, resulting in an increase in total caloric intake. In the paraventricular nucleus of the WL mice, the expression of fatty acid metabolism genes was increased in addition to several ion channels and neuropeptide receptors, but arachidonic acid metabolism genes were strongly suppressed. We are now analyzing feeding behavior after expression modification using viral vectors encoding these candidate genes for obese memory, and are investigating the regulatory mechanisms in detail.
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| Academic Significance and Societal Importance of the Research Achievements |
ストレス応答ホルモンであるCRHが惹起する炭水化物嗜好性変化は、生体の糖エネルギー需要を鋭敏に反映する。肥満に続く急激な減量時における新規神経ネットワークでは、ストレスによる急激な生体内環境変化におけるアンバランスなエネルギー調節機構を制御仕切れない可能性が高い。減量時の生体内エネルギー需要を嗜好性変化に着目して精確に検知し、適切な時期にCRHニューロン活動を制御することにより、摂食行動異常を是正する研究に発展させ摂食障害に対する新規ターゲット療法の確立につながると確信する。
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Report
(4 results)
Research Products
(32 results)
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[Journal Article] The Positivity of Phosphorylated STAT3 Is a Novel Marker for Favorable Prognosis in Germinal Center B-Cell Type of Diffuse Large B-Cell Lymphoma2021
Author(s)
K. Morichika, K. Karube, S. Sakihama, R. Watanabe, M. Kawaki, Y. Nishi, S. Nakachi, S. Okamoto, T. Takahara, A. Satou, S. Shimada, K. Shimada, T. Tsuzuki, T. Fukushima, S. Morishima and H. Masuzaki
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Journal Title
Am J Surg Pathol
Volume: -
Issue: 6
Pages: 832-840
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Retrospective exploratory analyses on gender differences in determinants for incidence and progression of diabetic retinopathy in Japanese patients with type 2 diabetes mellitus2021
Author(s)
Y. Nakayama, S. Yamaguchi, Y. Shinzato, S. Okamoto, J. F. Millman, K. Yamashiro, N. Takemoto, T. Uema, K. Arakaki, M. Higa, H. Koizumi, M. Shimabukuro and H. Masuzaki
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Journal Title
Endocrine Journal
Volume: 68
Issue: 6
Pages: 655-669
DOI
NAID
ISSN
0918-8959, 1348-4540
Related Report
Peer Reviewed / Open Access
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[Journal Article] Metabolically and immunologically beneficial impact of extra virgin olive and flaxseed oils on composition of gut microbiota in mice.2019
Author(s)
Millman J, Okamoto S*, Kimura A, Uema T, Higa M, Yonamine M, Namba T, Ogata E, Yamazaki S, Shimabukuro M, Tsutsui M, Matsushita M, Ikematsu S and Masuzaki H*
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Journal Title
European Journal of Nutrition
Volume: -
Issue: 6
Pages: 2411-2425
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] A pilot assessment of xanthine oxidase activity in plasma from patients with hematological malignancies using a highly sensitive assay.2019
Author(s)
Hokama N, Shirakura T, Sunagawa S, Morishima S, Nakachi S, Nishi Y, Murayama Y, Matsui C, Hase N, Tamura M, Okamoto S, Shimabukuro M, Nakamura K, Masuzaki H.
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Journal Title
Hematol Oncol.
Volume: 37
Issue: 4
Pages: 527-530
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Phosphorylated STAT3 expression predicts better prognosis in smoldering type of adult T-cell leukemia/lymphoma.2019
Author(s)
Morichika K, Karube K, Kayo H, Uchino S, Nishi Y, Nakachi S, Okamoto S, Morishima S, Ohshiro K, Nakazato I, Fukushima T, Masuzaki H.
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Journal Title
Cancer Sci.
Volume: 110
Issue: 9
Pages: 2982-2991
DOI
NAID
Related Report
Peer Reviewed / Open Access
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