| Project/Area Number |
18K11085
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 59040:Nutrition science and health science-related
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| Research Institution | Suzuka University of Medical Science |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | UVA / 光老化 / 記憶・学習能力 / 慢性炎症 / p53 / Clock gene / Sirt1 / 光生物学 / 紫外線 |
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| Outline of Final Research Achievements |
Long-term eye exposure to UVA can effect memory and learning ability. However, the underlying mechanism behind these effects remain unknown. In this study, we used mice to study effects of long-term UVA eye irradiation. The eyes of the mice were exposed to UVA at the dose of 110kj/m2 using an FL20SBLB-A lamp three times a week over 12 months. Our results showed that UVA eye irradiation potentially mediated a decline in memory and learning ability via enhancing levels of urocortin 2, microglia, and β-amyloid in the brain. In addition, we found that the p53 level increased significantly following long-term UVA eye irradiation, whereas the levels of Period2, Bmal1, Clock, NMNAT and NAMPT activities, NAD+ , and Sirt1 decreased significantly.
These results indicate that it was shown that UVA eye irradiation leads to aging of the whole body by controlling the hormonal system, the inflammatory system and the clock gene system.
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| Academic Significance and Societal Importance of the Research Achievements |
UVA長期眼照射による光老化の誘導は申請者が発見した新規領域で極めて独創的であり、現在大きな問題になっている紫外線による病態の予防軽減法開発に有効であり、その意義は極めて大きい。
さらに本研究結果は、UVA長期眼照射による光老化と時計遺伝子の関係に言及した報告であり、現在社会における生活習慣の乱れ（夜更かしや昼夜逆転）による様々な肉体的および精神的疾患と光老化を結びつける重要な研究である。
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