Elucidation of the function mechanism of peptides that promote melatonin synthesis isolated from fermented whey
| Project/Area Number |
18K11090
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Review Section |
Basic Section 59040:Nutrition science and health science-related
|
|---|
| Research Institution | Shujitsu University |
|---|
Principal Investigator |
Tsuboi Seiji 就実大学, 薬学部, 教授 (50172052)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
川上 賀代子 就実大学, 薬学部, 助教 (00505935)
守谷 智恵 就実大学, 薬学部, 教授 (60253001)
|
|---|
| Project Period (FY) |
2018-04-01 – 2021-03-31
|
| Project Status |
Completed (Fiscal Year 2020)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
|---|
| Keywords | グルタチオン / 発酵乳ホエー / メラトニン合成酵素 / メラトニン / VPP / IPP / 睡眠 / アセトアミノフェン / 肝障害 / 機能性食品 |
|---|
| Outline of Final Research Achievements |
Melatonin is a highly lipophilic hormone in pineal glands and plays important roles in many biological processes, especially in circadian rhythm and seasonal reproduction. Serotonin N-acetyltransferase (NAT) is a key enzyme for melatonin synthesis. We demonstrated that novel regulation of NAT activity by glutathione, in which an intramolecular disulfide bond may function as a switch for catalysis. In this study, fermented whey increased the intracellular glutathione level and NAT activity in COS7/NAT cells, and 9 types of peptides that increased NAT activity were identified from fermented whey.
|
| Academic Significance and Societal Importance of the Research Achievements |
睡眠は、人が生存する上で衣食住とともに重要な課題である。睡眠不足の原因の一つとしては、脳内で作られる睡眠ホルモンであるメラトニン分泌リズムの異常が考えられる。我々は、メラトニン生合成の律速酵素であるserotonin N-acetyltransferase (NAT)について研究を行っている。本研究により、発酵乳ホエーよりNAT制御・メラトニン量上昇・良質の睡眠確保する物質９種類のペプチドを同定した。その成果を社会に生かし、科学的根拠に基づく生活の質の向上へとつながる全く新しい機能性食品産業の創出が期待できる。
|
Report
(4 results)
Research Products
(34 results)
