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Effects of vitamin E on improving nonalcoholic steatohepatitis (NASH) focusing on the hepatic microenvironment

Research Project

Project/Area Number 18K11096
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 59040:Nutrition science and health science-related
Research InstitutionSeitoku University (2020-2022)
Ochanomizu University (2018-2019)

Principal Investigator

Tomoko Ishikawa  聖徳大学, 人間栄養学部, 教授 (70212850)

Co-Investigator(Kenkyū-buntansha) 藤原 葉子  お茶の水女子大学, 基幹研究院, 教授 (50293105)
日下部 守昭  東京大学, 大学院農学生命科学研究科(農学部), 特任教授 (60153277)
Project Period (FY) 2018-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords肝疾患 / 栄養 / 細胞・組織
Outline of Final Research Achievements

Administration of vitamin E is the sole medication for nonalcoholic steatohepatitis (NASH), but it is not considered the gold standard because of the balance between therapeutic benefits and adverse reactions. This study aims to establish more efficient vitamin E therapies. Using diet-induced NASH model mice, we investigated differences in effects among vitamin E homologues, synergistic effects with antioxidants, and influence of hepatic microenvironment on recovery and progression of NASH during the early onset, advanced, and healing stages of NASH.

Academic Significance and Societal Importance of the Research Achievements

非アルコール性脂肪肝炎(NASH)は、近い将来、日本における肝癌の主因となる生活習慣病として注目され、有効な予防法、診断法および治療法の開発が望まれている。本研究成果は、ビタミンE同族体のトコトリエノールに肝線維化の抑制効果がみられること、多価不飽和脂肪酸との同時投与は炎症や脂質代謝の改善に寄与することを示唆している。病態に適したビタミンE投与タイミングの決定や、同族体配合の治療製剤開発の手掛かりとなることが期待される。

Report

(6 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (11 results)

All 2022 2021 2020 2019 2018

All Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 3 results) Presentation (8 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Effect of tocotrienol on the primary progression of nonalcoholic steatohepatitis in a mouse model2022

    • Author(s)
      Noichi J, Ishikawa T, Ichi I and Fujiwara Y
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 70 Issue: 2 Pages: 140-146

    • DOI

      10.3164/jcbn.21-69

    • NAID

      130008165960

    • ISSN
      0912-0009, 1880-5086
    • Related Report
      2022 Annual Research Report 2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Fc gamma RIIb expression levels in human liver sinusoidal endothelial cells during progression of non-alcoholic fatty liver disease2019

    • Author(s)
      Ishikawa Tomoko、Yokoyama Hiroshi、Matsuura Tomokazu、Fujiwara Yoko
    • Journal Title

      PLOS ONE

      Volume: 14 Issue: 1 Pages: e0211543-e0211543

    • DOI

      10.1371/journal.pone.0211543

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Vitronectin deficiency attenuates hepatic fibrosis in a non-alcoholic steatohepatitis-induced mouse model.2019

    • Author(s)
      Momoka Hayashida, Kei Hashimoto, Tomoko Ishikawa, Yasunori Miyamoto
    • Journal Title

      Int. J. Exp. Pathol.

      Volume: - Issue: 2 Pages: 72-82

    • DOI

      10.1111/iep.12306

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Influence of extracellular matrix deficiency on effects of vitamin E during recovery from the diet-induced NASH2022

    • Author(s)
      Tomoko Ishikawa, Moriaki Kusakabe, Yoko Fujiwara
    • Organizer
      22nd International Congress of Nutrition
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 食餌誘発性NASHモデルマウスにおけるビタミンEと魚油の効果2021

    • Author(s)
      藤原葉子、市育代、石川朋子
    • Organizer
      第367回脂溶性ビタミン総合研究委員会
    • Related Report
      2020 Research-status Report
  • [Presentation] 食餌誘発性NASHモデルを用いた炎症の進行における魚油とビタミンEの影響2020

    • Author(s)
      高橋咲貴、石川朋子、市育代、藤原葉子
    • Organizer
      日本ビタミン学会第72回大会
    • Related Report
      2020 Research-status Report
  • [Presentation] NASH進行過程における魚油とビタミンEの経口投与による相乗効果の検討2020

    • Author(s)
      高橋咲貴、石川朋子、市育代、藤原葉子
    • Organizer
      第31回ビタミンE研究会
    • Related Report
      2019 Research-status Report
  • [Presentation] 食事誘導性非アルコール性脂肪肝炎の治癒過程における間質微小環境の影響2019

    • Author(s)
      石川朋子、日下部守昭、藤原葉子
    • Organizer
      第60回日本組織細胞化学会総会・学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] アルコール性脂肪肝炎発症初期の間質微小環境の解析2018

    • Author(s)
      石川朋子、日下部守昭、藤原葉子
    • Organizer
      第59回日本組織細胞化学会総会・学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] ヒトNASH病態と肝類洞内皮細胞FcgammaR2b発現との関連2018

    • Author(s)
      石川朋子、横山寛、松浦知和、藤原葉子
    • Organizer
      第32回肝類洞壁細胞研究会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 非アルコール性脂肪肝炎発症過程におけるビタミンE摂取効果の検討2018

    • Author(s)
      石川朋子、乃一純、市育代、藤原葉子
    • Organizer
      日本ビタミン学会第70回大会
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2024-01-30  

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