• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Elucidation and application to treatment of the mechanism of intestinal regeneration dysfunction cased by high-fat diet intake and psychological stress ical stress and its application to treatment

Research Project

Project/Area Number 18K11120
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 59040:Nutrition science and health science-related
Research InstitutionNational Defense Medical College

Principal Investigator

Nomura Sayaka  防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究施設、病院並びに防衛, 薬理学, 助教 (20791651)

Co-Investigator(Kenkyū-buntansha) 佐藤 泰司  防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究施設、病院並びに防衛, 生化学, 教授 (10505267)
石塚 俊晶  防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究施設、病院並びに防衛, 薬理学, 教授 (30399117)
Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords腸管再生 / 脳炎症 / インフラマソーム / IL-6 / 分子状水素 / 高脂肪食 / 腸管炎症 / LPS / ミクログリア / LXR / オルガノイド / 腸管幹細胞 / 腸管分化 / LXRアゴニスト / TNF / Liver X receptor
Outline of Final Research Achievements

Treatment with LXR agonists in intestinal stem cells affected neither inflammasome activation nor differentiation into intestinal epithelial cells. It has been revealed that oxidative stress induces inflammasome activation. Treatemnt with molecular hydrogen, a potent antioxidant, improved intestinal regeneration and supressed gut injury in high fat diet-loaded senescence- accelerated mice prone 8 (SAMP8 mice).

Academic Significance and Societal Importance of the Research Achievements

本研究の実施前に予測していたLXRアゴニストによるインフラマソーム活性化抑制による腸管再生機能の改善作用は確認できなかった。しかし、インフラマソーム活性化を促進する酸化ストレスを抑制する分子状水素の投与は腸管再生機能を回復させ腸管障害を抑制させることが明らかになった。高脂肪食摂取による腸管再生機能障害とそれに伴う炎症性腸疾患の増悪への酸化ストレスの関与が明らかになり、分子状水素を含めた抗酸化治療の有効性が確認された。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (21 results)

All 2022 2021 2020 2019 2018

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (14 results) (of which Int'l Joint Research: 3 results) Book (1 results)

  • [Journal Article] Effects of oxidized low-density lipoprotein on differentiation of mouse neural progenitor cells into neural cells2020

    • Author(s)
      Toshiaki Ishizuka, Nagata Wataru, Nomura Sayaka, Yasushi Satoh
    • Journal Title

      Eur J Pharmacol

      Volume: 888 Pages: 173456-173456

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] 生化学、薬理学、麻酔科学との水平・垂直統合のリレー講義の経験と課題2020

    • Author(s)
      石塚 俊晶
    • Journal Title

      日本薬理学雑誌

      Volume: 155 Pages: 329-331

    • NAID

      130007894595

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Low body mass index and lymphocytopenia associate with Mycobacterium avium complex pulmonary disease in patients with rheumatoid arthritis.2019

    • Author(s)
      Hirose W, Harigai M, Uchiyama T, Itoh K, Ishizuka T, Matsumoto M, Nanki T.
    • Journal Title

      Modern Rheumatology

      Volume: 29 Issue: 1 Pages: 105-112

    • DOI

      10.1080/14397595.2018.1452334

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Molecular hydrogen prevents social deficits and depression-like behaviours induced by low-intensity blast in mice.2018

    • Author(s)
      Satoh Y, Araki Y, Kashitani M, Nishii K, Kobayashi Y, Fujita M, Suzuki S, Morimoto Y, Tokuno S, Tsumatori G, Yamamoto T, Saitoh D, Ishizuka T.
    • Journal Title

      J Neuropathol Exp Neurol

      Volume: 77 Issue: 9 Pages: 827-836

    • DOI

      10.1093/jnen/nly060

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Nicotine treatment ameliorates DSS-induced colitis by suppressing MAdCAM-1 expression and leukocyte recruitment.2018

    • Author(s)
      Maruta K, Watanabe C, Hozumi H, Kurihara C, Furuhashi H, Takajo T, Okada Y, Shirakabe K, Higashiyama M, Komoto S, Tomita K, Nagao S, Ishizuka T, Miura S, Hokari R.
    • Journal Title

      J Leukoc Biol

      Volume: 104 Issue: 5 Pages: 1013-1022

    • DOI

      10.1002/jlb.3a0717-304r

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of muscarinic acetylcholine receptor stimulation on the differentiation of mouse induced pluripotent stem cells into neural progenitor cells.2018

    • Author(s)
      Ishizuka T, Ozawa A, Katsuura M, Nomura S, Satoh Y.
    • Journal Title

      Clin Exp Pharmacol Physiol

      Volume: 45 Issue: 11 Pages: 1198-1205

    • DOI

      10.1111/1440-1681.12993

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Presentation] The ameliorating effects of molecular hydrogen on intestinal injury in high fat diet-loaded senescence-accelerated mouse2022

    • Author(s)
      Nomura Sayaka, Nakagawa keiichi, Nagata Wataru, Koizumi Akiho, Ishizuka Toshiaki
    • Organizer
      第95回日本薬理学会年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Treatment with lysophosphatidic acid(LPA)improves depressive-like behaviors in neuropsychiatric lupus erythematosus (NPSLE) model mice through LPA receptor2022

    • Author(s)
      永田 亘、小泉 明穂、 中川 慶一、 野村 さやか、深澤 桂子、後藤真理、石塚 俊晶
    • Organizer
      第95回日本薬理学会年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Cyclic phosphatidic acid improves depression in a mouse model of neuropsychiatric lupus erythematosus (NPSLE)2021

    • Author(s)
      永田 亘、小泉 明穂、 中川 慶一、 野村 さやか、深澤 桂子、後藤真理、石塚 俊晶
    • Organizer
      日本ヒト細胞学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 高濃度水素含有ゼリーは高脂肪食負荷老化促進マウスの腸管障害を改善する2021

    • Author(s)
      Nomura Sayaka, Nakagawa keiichi, Nagata Wataru, Koizumi Akiho, Ishizuka Toshiaki
    • Organizer
      第10回日本分子状水素医学生物学会大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Transrepression作用選択的なLiver X受容体リガンドの創製とインフラマソーム活性化に及ぼす影響の検討2021

    • Author(s)
      石塚俊晶、野村さやか、 梅田(遠藤)香織、 槇島誠、橋本祐一、 石川稔
    • Organizer
      第94回日本薬理学会年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 高脂肪食およびLPS投与が脳内炎症、神経新生および認知機能の及ぼす影響2021

    • Author(s)
      石塚 俊晶
    • Organizer
      第94回日本薬理学会年会
    • Related Report
      2020 Research-status Report
  • [Presentation] Transrepression作用選択的なLiver X受容体リガンドの創製とインフラマソーム活性化に及ぼす影響の検討2021

    • Author(s)
      野村 さやか
    • Organizer
      第94回日本薬理学会年会
    • Related Report
      2020 Research-status Report
  • [Presentation] Transrepression作用選択的LXRリガンドはミクログリアや神経前駆細胞のインフラマソーム活性化を抑制する2020

    • Author(s)
      石塚 俊晶
    • Organizer
      第38回ヒト細胞学会
    • Related Report
      2020 Research-status Report
  • [Presentation] Effects of inflammasome activation on proliferation and differentiation of neural progenitor cells2019

    • Author(s)
      Ishizuka T, Ozawa A, Nomura S, Satoh Y.
    • Organizer
      第92回日本薬理学会年会
    • Related Report
      2018 Research-status Report
  • [Presentation] The role of BK channels in spinal microglia for the induction of neuropathic pain in mice.2019

    • Author(s)
      Satoh Y, Morohashi T, Hayashi Y, Itakura S, Kawaguchi M, Nakanishi H, Ishizuka T.
    • Organizer
      第92回日本薬理学会年会
    • Related Report
      2018 Research-status Report
  • [Presentation] Effects of inflammasomes on differentiation of neural progenitor cells into neural cells.2018

    • Author(s)
      Ishizuka Toshiaki, Ozawa Ayako, Nomura Sayaka, Yasushi Satoh
    • Organizer
      ISSCR 2018 Annual Meeting
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Activation of inflammasomes in neural progenitor cells inhibits differentiation into neural cells.2018

    • Author(s)
      Ishizuka Toshiaki, Ozawa Ayako, Nomura Sayaka, Yasushi Satoh
    • Organizer
      18th World Congress of Basic and Clinical Pharmacology
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Development of transrepression-selective liver X receptor ligands.2018

    • Author(s)
      Nomura S, Umeda K, Makishima M, Hashimoto Y, Ishizuka T, Ishikawa M.
    • Organizer
      18th World Congress of Basic and Clinical Pharmacology
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Transrepression作用選択的なLiver X受容体リガンドの創製と腸管新生作用の検討2018

    • Author(s)
      野村さやか、梅田香織、槇島誠、橋本祐一、石塚俊晶、石川稔
    • Organizer
      第36回ヒト細胞学会
    • Related Report
      2018 Research-status Report
  • [Book] Regulation of signal transduction in human cell research. (Chapter 2: Role of the receptor-mediated signaling pathways on the proliferation and differentiation of pluripotent stem cells.)2018

    • Author(s)
      Ishizuka T (edited by Shinomiya N, Kataoka H, Xie Q)
    • Publisher
      Springer
    • ISBN
      9789811072956
    • Related Report
      2018 Research-status Report

URL: 

Published: 2018-04-23   Modified: 2023-01-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi