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Study on the effect of food on the expression of serum microRNAs

Research Project

Project/Area Number 18K11124
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 59040:Nutrition science and health science-related
Research InstitutionUniversity of Tsukuba

Principal Investigator

Suzuki Hiroaki  筑波大学, 医学医療系, 准教授 (40344890)

Co-Investigator(Kenkyū-buntansha) 深津 佳世子 (佐々木)  共立女子大学, 家政学部, 教授 (70338903)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords血中microRNA / 食品 / 分岐鎖アミノ酸 / 大豆タンパク / 骨格筋 / インスリン抵抗性 / 抑うつ / microRNA / ランダム化比較試験 / 玄米 / 機能性食品
Outline of Final Research Achievements

The aim of this study was to determine if changes in blood microRNAs (miRNAs) could be a marker of food functionality. In a randomized controlled trial (RCT) comparing a brown rice diet with a white rice diet, significant differences in expression were found between the brown and white rice groups for four of 176 miRNAs. In an RCT comparing BCAA supplementation with soy protein supplementation, changes were observed in 16 of 768 miRNAs, two of which moved in opposite directions in the two groups. For some of the miRNAs that were altered in the two studies, there was a correlation between changes in miRNA expression and changes in metabolic status.

Academic Significance and Societal Importance of the Research Achievements

血中microRNA (miRNA) の変化は、がん患者でも認められ、特定のがんをターゲットとしたmiRNAのパネルも発売されている。今回の研究成果により、血中miRNAの変化が食品によってもたらされる代謝状態の変化の一部を反映していることが示された。これまでは、動物実験や細胞を用いた実験で機能を推定していたが、これらによって示された効果が、必ずしもヒトに投与した場合に再現できないことも多く、血清miRNAによるliquid biopsyは、食品の機能性のみならず、薬品などの機能性を評価するのにも有用であると考えられた。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (9 results)

All 2020 2019 2018

All Journal Article (4 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 4 results,  Open Access: 2 results) Presentation (5 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] The Possibility of Suppression of Increased Postprandial Blood Glucose Levels by Gamma-Polyglutamic Acid-Rich Natto in the Early Phase after Eating: A Randomized Crossover Pilot Study2020

    • Author(s)
      Araki Risa、Fujie Keiko、Yuine Nanako、Watabe Yuta、Maruo Kazushi、Suzuki Hiroaki、Hashimoto Koichi
    • Journal Title

      Nutrients

      Volume: 12 Issue: 4 Pages: 915-915

    • DOI

      10.3390/nu12040915

    • NAID

      120007147864

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Olive leaf tea is beneficial for lipid metabolism in adults with prediabetes: an exploratory randomized controlled trial2019

    • Author(s)
      Araki Risa、Fujie Keiko、Yuine Nanako、Watabe Yuta、Nakata Yoshio、Suzuki Hiroaki、Isoda Hiroko、Hashimoto Koichi
    • Journal Title

      Nutrition Research

      Volume: 67 Pages: 60-66

    • DOI

      10.1016/j.nutres.2019.05.003

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] オリーブ葉茶の継続摂取によるヒトの血中脂質濃度改善効果の検討2019

    • Author(s)
      荒木 理沙, 藤江 敬子, 渡部 裕太, 唯根 菜々子, 鈴木 浩明, 礒田 博子, 橋本 幸一
    • Journal Title

      応用薬理

      Volume: 96 Pages: 101-108

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] An Exploratory Study of the Effects of Continuous Intake of Olive Leaf Tea on Physique and Glucose and Lipid Metabolism2018

    • Author(s)
      Araki Risa、Fujie Keiko、Nakata Yoshio、Suzuki Hiroaki、Matsui Koichi、Uematsu Katsutaro、Shibasaki Hiroyuki、Ando Takahiko、Ueyama Yukari、Isoda Hiroko、Hashimoto Koichi
    • Journal Title

      Nippon Eiyo Shokuryo Gakkaishi

      Volume: 71 Issue: 3 Pages: 121-131

    • DOI

      10.4327/jsnfs.71.121

    • NAID

      130007396879

    • ISSN
      0287-3516, 1883-2849
    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Health benefits of olive leaf tea for adults with pre-diabetes: An exploratory randomized controlled trial.2019

    • Author(s)
      Araki R, Fujie K, Yuine N, Watababe Y, Nakata Y, Suzuki H, Isoda H, Hashimoto K
    • Organizer
      The 9th International Conference on Polyphenols and Health
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 玄米食における血中microRNAの変化2019

    • Author(s)
      鈴木浩明、荒木里沙、深津佳世子、藤江敬子、関谷元博、中川嘉、松坂賢、中田由夫、矢作直也、橋本幸一、島野仁
    • Organizer
      第34回日本静脈経腸栄養学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] Association between brown rice consumption and changes of circulating microRNAs in Japanese subjects with prediabetes2018

    • Author(s)
      Suzuki H, Araki R, Sasaki-Fukatsu K, Fujie K, Nakagawa Y, Matsuzaka T, Nakata Y, Hashimoto K, Shimano H
    • Organizer
      55th Annual Meeting of the European Association for the Study of Diabetes
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 高γ-poly glutamic acid納豆の単回摂取がヒトの食後血糖変動に及ぼす影響の検討2018

    • Author(s)
      唯根菜々子, 荒木理沙, 藤江敬子, 渡部裕太, 鈴木浩明, 橋本幸一
    • Organizer
      第23回日本フードファクター学会・第12回日本ポリフェノール学会・第15回日本カテキン学会合同学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] オリーブ葉茶の継続摂取がヒトの健康に及ぼす影響の検討2018

    • Author(s)
      荒木理沙, 藤江敬子, 唯根菜々子, 渡部裕太, 中田由夫, 鈴木浩明, 松井幸一, 植松勝太郎, 柴﨑博行, 礒田博子, 橋本幸一
    • Organizer
      第72回日本栄養・食糧学会大会
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2022-01-27  

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