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Importance of intestinal environment on the prevention of obesity-induced sarcopenia

Research Project

Project/Area Number 18K11130
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 59040:Nutrition science and health science-related
Research InstitutionOita University

Principal Investigator

GOTOH KORO  大分大学, 医学部, 講師 (10457624)

Co-Investigator(Kenkyū-buntansha) 正木 孝幸  大分大学, 医学部, 准教授 (00423715)
柴田 洋孝  大分大学, 医学部, 教授 (20245484)
加隈 哲也  大分大学, 保健管理センター, 准教授 (80343359)
岡本 光弘  大分大学, 医学部, 助教 (80774546)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords肥満 / サルコペニア / 腸内環境 / 炎症 / マイオカイン / 小腸
Outline of Final Research Achievements

Obesity induces systemic low-grade inflammation although the mechanism is uncertain. Recently, it is reported that “myokine” secreted from muscle, such as IL-15 and IL-6 promotes the enlargement of muscle fibers. Recently, obesity sarcopenia is also associated with lipopolysaccharide (LPS) released from intestine by collapsing intestinal barrier associated with intestinal inflammation, which induces inflammatory responses in muscle. It is well-known that soybean dietary fiber has an effect of improving the intestinal environment. The intake of soybean dietary fiber decreased plasma LPS concentration which elevates during HF feeding. This treatment also improved the reduction of myokines such as IL-15 induced by HF diet. Furthermore, HF-induced inflammation, atrophy of muscle fibers, and function of intestinal barrier were ameliorated by soybean dietary fiber treatment. Thus, we suggest that the intake of soybean might be effective to prevent the development of obesity sarcopenia.

Academic Significance and Societal Importance of the Research Achievements

肥満サルコぺニアに対する治療は、運動とカロリーを中心とした食事制限である。ところが、肥満者の人口が増加する傾向にあることを考慮すると、その実効性については疑問視される。現代のような欧米化した食生活のなかに大豆製品を積極的に取り入れ、腸内環境を整えることが重要であるということを本研究は示唆していると考える。
このような現象は高齢者にも該当すると考える。国連が国際目標として提示したSDGsのなかに、Leave No One Behind 「誰ひとり取り残さない」とある。したがって、肥満者や高齢者に対して大豆を摂取するように啓蒙していけばサルコペニアの発症をある程度防ぐことが可能であると推測される。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report

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Published: 2018-04-23   Modified: 2022-01-27  

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