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Statistical approach and feedback for genetic, epidemiological or clinical data.

Research Project

Project/Area Number 18K11189
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 60030:Statistical science-related
Research InstitutionYokohama City University (2019-2022)
Tokyo Medical and Dental University (2018)

Principal Investigator

Tomita Makoto  横浜市立大学, データサイエンス学部, 教授 (20399025)

Project Period (FY) 2018-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsゲノムデータ解析 / 空間集積性 / データサイエンス学部 / ヘルスデータサイエンス研究 / ゲノムデータ / 統計コンサルティング / ヘルスデータサイエンス / 臨床研究 / 統計モデリング / 統計解析 / 生物統計学 / 健康保健データ / 対象患者 / リスク解析 / 臨床データ / 遺伝統計学 / ゲノム / 保健データ / 医療データ / 空間統計 / リスク推定
Outline of Final Research Achievements

In recent years, studies of genetic diversity analysis have moved toward larger and larger data sets, and studies of epidemiology and mental health data have also begun to deal with large, spatially sampled, and vast amounts of information. The former is not simply a matter of statistical analysis, but has a unique genetic approach in this field, while the latter is also limited in its applicability due to computational expansion and practical limitations in computing time when considering spatial agglomeration.
Regarding the status of the use of data science, he gave an invited oral presentation at ECDA 2022 (Naples, Italy), and his paper summarized as an overview of genomic data analysis was accepted by WIREs Computational Statistics and will be published in 2023.

Academic Significance and Societal Importance of the Research Achievements

データサイエンスを活用した状況については、ECDA2022(Naples, Italy)で招聘の口頭発表を行い、ゲノムデータ解析の統括としてまとめた論文がWIREs Computational Statisticsに採択され、2023年に掲載される運びとなった。前者は、本研究より大きな枠組みとなるデータサイエンスやヘルスデータサイエンスの潮流や最新情報を含むものであり、後者はゲノムデータ解析にまつわるデータ検証やデータ構造、解析アプローチなどを総合的に紹介しており、分野に専門・非専門を問わず有用な知識と情報を寄与できるものとなった。

Report

(6 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (19 results)

All 2023 2022 2021 2020 2019 2018

All Journal Article (16 results) (of which Int'l Joint Research: 11 results,  Peer Reviewed: 16 results,  Open Access: 5 results) Presentation (3 results) (of which Int'l Joint Research: 3 results,  Invited: 3 results)

  • [Journal Article] Data validation and statistical issues such as power and other considerations in genome‐wide association study (GWAS)2023

    • Author(s)
      Tomita Makoto
    • Journal Title

      WIREs Computational Statistics

      Volume: 15 Issue: 3

    • DOI

      10.1002/wics.1601

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Alterations in cartilage quantification before and after injections of mesenchymal stem cells into osteoarthritic knees2021

    • Author(s)
      Sekiya Ichiro、Katano Hisako、Mizuno Mitsuru、Koga Hideyuki、Masumoto Jun、Tomita Makoto、Ozeki Nobutake
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1

    • DOI

      10.1038/s41598-021-93462-8

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Effect of melatonin and melatonin agonists on postoperative sleep quality in adult patients: a protocol for systematic review and meta-analysis with trial sequential analysis2021

    • Author(s)
      Tsukinaga Akito、Mihara Takahiro、Takeshima Teppei、Tomita Makoto、Goto Takahisa、Yamanaka Takeharu
    • Journal Title

      BMJ Open

      Volume: 11 Issue: 9 Pages: e047858-e047858

    • DOI

      10.1136/bmjopen-2020-047858

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Difference in the joint space of the medial knee compartment between full extension and Rosenberg weight-bearing radiographs2021

    • Author(s)
      Miura Yugo、Ozeki Nobutake、Katano Hisako、Aoki Hayato、Okanouchi Noriya、Tomita Makoto、Masumoto Jun、Koga Hideyuki、Sekiya Ichiro
    • Journal Title

      European Radiology

      Volume: 32 Issue: 3 Pages: 1429-1437

    • DOI

      10.1007/s00330-021-08253-6

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Comparison of combination therapy of prednisolone and cyclosporine with corticosteroid pulse therapy in Vogt?Koyanagi?Harada disease2021

    • Author(s)
      Ono Takashi、Goto Hiroshi、Sakai Tsutomu、(中間省略)、Tomita Makoto、The Japan VKH Disease Treatment Study Group
    • Journal Title

      Japanese Journal of Ophthalmology

      Volume: 66 Issue: 2 Pages: 119-129

    • DOI

      10.1007/s10384-021-00878-w

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical Characteristics, Management, and Factors Associated with Poor Visual Prognosis of Acute Retinal Necrosis2020

    • Author(s)
      Takase Hiroshi、Goto Hiroshi、Namba Kenichi、Mizuki Nobuhisa、Okada Annabelle A、Ohguro Nobuyuki、Sonoda Koh-Hei、Tomita Makoto、Keino Hiroshi、Kezuka Takeshi、Kubono Reo、Mizuuchi Kazuomi、Shibuya Etsuko、Takahashi Hiroyuki、Yanai Ryoji、Mochizuki Manabu
    • Journal Title

      Ocular Immunology and Inflammation

      Volume: - Issue: 1 Pages: 1-6

    • DOI

      10.1080/09273948.2020.1789179

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Changes in serum KL-6 levels during short-term strict antigen avoidance are associated with the prognosis of patients with fibrotic hypersensitivity pneumonitis caused by avian antigens2020

    • Author(s)
      Hanzawa Satoshi、Tateishi Tomoya、Ishizuka Masahiro、Inoue Yukihisa、Honda Takayuki、Kawahara Tatsuo、Tomita Makoto、Miyazaki Yasunari
    • Journal Title

      Respiratory Investigation

      Volume: 58 Issue: 6 Pages: 457-464

    • DOI

      10.1016/j.resinv.2020.05.007

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] An open-label, randomized controlled trial of sulfamethoxazole?trimethoprim for Pneumocystis prophylaxis: results of 52-week follow-up2020

    • Author(s)
      Utsunomiya Masako、Dobashi Hiroaki、Odani Toshio、Saito Kazuyoshi、Yokogawa Naoto、Nagasaka Kenji、Takenaka Kenchi、Soejima Makoto、Sugihara Takahiko、Hagiyama Hiroyuki、Hirata Shinya、Matsui Kazuo、Nonomura Yoshinori、Kondo Masahiro、Suzuki Fumihito、Nawata Yasushi、Tomita Makoto、et al.
    • Journal Title

      Rheumatology Advances in Practice

      Volume: 4 Issue: 2

    • DOI

      10.1093/rap/rkaa029

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] A cognitive bias in diagnostic reasoning and its remediation by the “2-Dimensional Approach”2020

    • Author(s)
      Shimozono Hisashi、Nawa Nobutoshi、Takahashi Makoto、Tomita Makoto、Tanaka Yujiro
    • Journal Title

      MedEdPublish

      Volume: 9 Pages: 123-123

    • DOI

      10.15694/mep.2020.000123.1

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Corrugated Sheet of Unsintered Hydroxyapatite Poly-L-Lactide for Sternal Fixation: A Preclinical Study2020

    • Author(s)
      Kuroki Hidehito、Arai Hirokuni、Srisont Smith、Oi Keiji、Tomita Makoto、Mizuno Tomohiro
    • Journal Title

      Annals of Thoracic and Cardiovascular Surgery

      Volume: 26 Issue: 1 Pages: 40-46

    • DOI

      10.5761/atcs.oa.19-00250

    • NAID

      130007800568

    • ISSN
      1341-1098, 2186-1005
    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Serum CXCL9 and CCL17 as biomarkers of declining pulmonary function in chronic bird-related hypersensitivity pneumonitis2019

    • Author(s)
      Nukui Yoshihisa、Yamana Takashi、Masuo Masahiro、Tateishi Tomoya、Kishino Mitsuhiro、Tateishi Ukihide、Tomita Makoto、Hasegawa Takehiro、Aritsu Takashi、Miyazaki Yasunari
    • Journal Title

      PLOS ONE

      Volume: 14 Issue: 8 Pages: e0220462-e0220462

    • DOI

      10.1371/journal.pone.0220462

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] “The 2-Dimensional Approach”: a novel tool to help learners organize their knowledge and improve their clinical reasoning skills.2019

    • Author(s)
      Shimozono Hisashi、Takahashi Makoto、Tomita Makoto、Takada Kazuki、Tanaka Yujiro
    • Journal Title

      MedEdPublish

      Volume: 8 Pages: 134-134

    • DOI

      10.15694/mep.2019.000134.1

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Comparison of Rigid and Soft-Brace Treatments for Acute Osteoporotic Vertebral Compression Fracture: A Prospective, Randomized, Multicenter Study2019

    • Author(s)
      Kato Tsuyoshi, Inose Hiroyuki, Shoichi Ichimura, Yasuaki Tokuhashi, Hiroaki Nakamura, Masatoshi Hoshino, Daisuke Togawa, Toru Hirano, Hirotaka Haro, Tetsuro Ohba, Takashi Tsuji, Kimiaki Sato, Yutaka Sasao, Masahiko Takahata, Koji Otani, Suketaka Momoshima , Ukihide Tateishi, Makoto Tomita, Ryuichi Takemasa, et al.
    • Journal Title

      Journal of Clinical Medicine

      Volume: 8 Issue: 2 Pages: 198-198

    • DOI

      10.3390/jcm8020198

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effects of propofol versus sevoflurane on cerebral circulation time in patients undergoing coiling for cerebral artery aneurysm: a prospective randomized crossover study2019

    • Author(s)
      Ishibashi Tomoko、Toyama Satoshi、Miki Kazunori、Karakama Jun、Yoshino Yoshikazu、Ishibashi Satoru、Tomita Makoto、Nemoto Shigeru
    • Journal Title

      Journal of Clinical Monitoring and Computing

      Volume: 5 Issue: 6 Pages: 1-12

    • DOI

      10.1007/s10877-018-00251-2

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Trends in isolated meniscus repair and meniscectomy in Japan, 2011-20162018

    • Author(s)
      Katano Hisako、Koga Hideyuki、Ozeki Nobutake、Otabe Koji、Mizuno Mitsuru、Tomita Makoto、Muneta Takeshi、Sekiya Ichiro
    • Journal Title

      Journal of Orthopaedic Science

      Volume: 23 Issue: 4 Pages: 676-681

    • DOI

      10.1016/j.jos.2018.04.003

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A diagnostic decision tree for adult cerebellar ataxia based on pontine magnetic resonance imaging2018

    • Author(s)
      Higashi Miwa、Ozaki Kokoro、Hattori Takaaki、Ishii Takashi、Soga Kazumasa、Sato Nozomu、Tomita Makoto、Mizusawa Hidehiro、Ishikawa Kinya、Yokota Takanori
    • Journal Title

      Journal of the Neurological Sciences

      Volume: 387 Pages: 187-195

    • DOI

      10.1016/j.jns.2018.02.022

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] Health Data Science Research and Education Initiatives in Japan.2022

    • Author(s)
      Makoto Tomita
    • Organizer
      European Conference of Data Analysis 2022, Naples, Italy.
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Summary of bio-statistical consultation for clinical research support in Japan2019

    • Author(s)
      Makoto Tomita
    • Organizer
      62nd ISI World Statistics Congress 2019
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Genetic and Statistical Problems for Genome Association Study2018

    • Author(s)
      Makoto TOMITA
    • Organizer
      7th German-Japanese Symposium at TU Dortmund University (Dortmund, Germany)
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited

URL: 

Published: 2018-04-23   Modified: 2024-01-30  

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