Theoretical study on the oscillation and synchronization mechanisms in biological rhythms and the proposal of experimental studies
| Project/Area Number |
18K11464
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 61040:Soft computing-related
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Kori Hiroshi 東京大学, 大学院新領域創成科学研究科, 教授 (80435974)
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| Project Period (FY) |
2018-04-01 – 2023-03-31
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| Project Status |
Completed (Fiscal Year 2022)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 同期 / ネットワーク / 生物リズム / 同期現象 / 概日リズム |
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| Outline of Final Research Achievements |
As described in this report, we were able to achieve five main research results:
(1) stability of oscillator networks against noise and optimal network structure, (2) population dynamics and pattern formation of fibroblasts, (3) phase description theory of chaotic oscillators, (4) contribution to experimental studies of biological clocks, and (5) effect of fluid interaction of oscillators on transport efficiency.
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| Academic Significance and Societal Importance of the Research Achievements |
複数の自由度を持つ非線形現象のメカニズムの理解に、数理的アプローチは必須である。本研究では、生命システムにおける振動と同期のメカニズムと役割を理解するための数理的理論枠組みをいくつか構築することができた。また、細胞集団の動きやカオス振動と行った、振動・同期現象と密接な関係がある現象についても理論研究を進めることができた。これらの研究成果は非線形・散逸系の物理学や応用数学の発展に貢献するだけでなく、工学分野や生命科学分野においても活用されることが期待される。
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Report
(6 results)
Research Products
(14 results)
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[Journal Article] A light-induced small G-protein gem limits the circadian clock phase-shift magnitude by inhibiting voltage-dependent calcium channels.2022
Author(s)
Matsuo M, Seo K, Taruno A, Mizoro Y, Yamaguchi Y, Doi M, Nakao R, Kori H, Abe T, Ohmori H, Tominaga K, Okamura H
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Journal Title
Cell Rep
Volume: 39
Issue: 8
Pages: 110844-110844
DOI
Related Report
Peer Reviewed / Open Access
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