Exploring selective inhibitory systems in the brain to generate the individual variability of KANSEI

• Project/Area Number: 18K11507
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 61060:Kansei informatics-related
• Research Institution: Nihon University
• Principal Investigator: MATSUKAWA Mutsumi 日本大学, 医学部, 准教授 (90318436)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 感性脳科学 / 感性形成機構 / 個体差形成 / ストレス反応 / ストレス緩和 / 梨状葉皮質

Outline of Final Research Achievements

To clarify a selective and direct suppressive system in the brain, in which postnatal experiences change innate responses, we analyzed the stress-related activities of glomeruli in the olfactory bulb (OB) using predator odor induced stress responses. In the OB, a specific odorant receptor innervates spatially distinct glomeruli forming mirror-image maps. Our results suggest that simultaneous activation in both medial and lateral OB is necessary for inducing neural activities in the piriform cortex where might cause stress-like behavior.

Academic Significance and Societal Importance of the Research Achievements

動物の持つ先天的な反応が経験によって改変される際の選択的な脳内抑制システムを解明することは、感性における個体差の形成過程を明らかにするための重要な知見をもたらすと思われる。これらの結果を総合的に解析することが、ヒト個々人において感性の相違を生じる重要な要因を解明するために有用であると考えられ、ヒトそれぞれ個別の刺激に対する意図的なリセットや反応抑制などが可能となり、各個人における生活の質（Quality of Life (QOL)）の向上にも影響を与えるものと期待される。

Research Products

• [Journal Article] Simultaneous activities in both mirror-image glomerular maps in the olfactory bulb may have an important role in stress-related neuronal responses in mice (2020)
  • Author(s): Matsukawa, M., Katsuyama, N., Imada, M., Aizawa, S., Sato, T.
  • Journal Title: Brain Research Volume: 1732 Pages: 1-8
  • DOI: 10.1016/j.brainres.2020.146676
  • Peer Reviewed
• [Journal Article] Initial, transient, and specific interaction between G protein-coupled receptor and target G protein in parallel signal processing: a case of olfactory discrimination of cancer-induced odors. (2018)
  • Author(s): Sato, T., Matsukawa, M., Mizutani, Y., Iijima, T., Matsumura, H.
  • Journal Title: Med Res Arch. Volume: 6 Pages: 1-25
  • Peer Reviewed / Open Access
• [Presentation] ALSモデルマウスの脊髄と脊髄神経節で発現変動する遺伝子の共通性と相違性の解析. (2020)
  • Author(s): 吉川雅朗, 松川 睦, 大島秀規, 今田正人, 相澤 信.
  • Organizer: 第125回 日本解剖学会総会・全国学術集会
• [Presentation] ALSモデルマウスの脊髄と脊髄神経節で発現変動する遺伝子の共通性と相違性の解析. (2020)
  • Author(s): 吉川雅朗, 松川 睦, 大島秀規, 今田正人, 相澤 信.
  • Organizer: 第125回 日本解剖学会総会・全国学術集会.
• [Presentation] Both medial and dorsolateral part of the olfactory bulb might be crucial to the predator odor induced stress related activities. (2019)
  • Author(s): Matsukawa, M., Katsuyama, N., Imada, M., Aizawa, S., Sato, T.
  • Organizer: The 42nd Annual Meeting of the Japan Neuroscience Society
• [Presentation] A residue at the 2nd position of GPCR helix 8 may control initial transient and specific interactions with target G proteins and subsequent signal processing hierarchy. (2018)
  • Author(s): Sato, T., Matsukawa, M., Mizutani, Y., Kobayakawa, R., Kobayakawa, K., Iijima, T., Matsumura, H.
  • Organizer: The 41st Annual Meeting of the Japan Neuroscience Society
• [Presentation] Analysis of DRG neurons in ALS model mice. (2018)
  • Author(s): Yoshikawa, M., Matsukawa, M., Oshima, H., Aizawa, S.
  • Organizer: The 41st Annual Meeting of the Japan Neuroscience Society