Establishing genome-wide analysis of RNA guanine quadruplexes conserved among species
| Project/Area Number |
18K11526
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 62010:Life, health and medical informatics-related
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| Research Institution | Osaka University |
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Principal Investigator |
Kato Yuki 大阪大学, 大学院医学系研究科, 准教授 (10511280)
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| Project Period (FY) |
2018-04-01 – 2023-03-31
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| Project Status |
Completed (Fiscal Year 2022)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | RNA / G4重鎖 / トランスクリプトーム / G４重鎖 / ゲノムワイド |
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| Outline of Final Research Achievements |
Recent exhaustive analyses have revealed that a large majority of RNAs expressed in cells are non-coding RNAs (ncRNAs), which do not code proteins. G-quadruplexes (G4s) are special substructures that are formed in G-rich sequences, and recent reports say that ncRNAs may contain abundant G4s. However, it is almost unclear what a biological meaning of G4s is, how they are conserved among different species, and to what extent they are occupied in the whole genome. In this study, we developed a classification model for G4s, which will lead to identifying G4 regions in ncRNAs genome-wide among different species.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究を発展させることによって保存されたG４重鎖領域を網羅的に同定できれば、これを契機に作動装置を特定し、ひいてはncRNA中に埋め込まれたG４重鎖の生物学的意義を明らかにすることへとつながることが期待できる。G４重鎖はALSなどの神経変性疾患にも関与していることが明らかになりつつあるため、ncRNAの機能を規定する要素として保存されたG４重鎖領域を同定する本研究は、疾患病態を解明するための一里塚としても社会的意義に富んだ内容だと考える。
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Report
(6 results)
Research Products
(30 results)
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[Journal Article] RNA editing at a limited number of sites is sufficient to prevent MDA5 activation in the mouse brain2021
Author(s)
Jung In Kim, Taisuke Nakahama, Ryuichiro Yamasaki, Pedro Henrique Costa Cruz, Tuangtong Vongpipatana, Maal Inoue, Nao Kanou, Yanfang Xing, Hiroyuki Todo, Toshiharu Shibuya, Yuki Kato and Yukio Kawahara
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Journal Title
PLoS Genetics
Volume: 17,
Issue: 5
Pages: e1009516-e1009516
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Age-dependent decline in remyelination capacity is mediated by apelin-APJ signaling2021
Author(s)
Masumi Ito, Rieko Muramatsu, Yuki Kato, Bikram Sharma, Akiko Uyeda, Shogo Tanabe, Harutoshi Fujimura, Hiroyasu Kidoya, Nobuyuki Takakura, Yukio Kawahara, Masaki Takao, Hideki Mochizuki, Akiyoshi Fukamizu, Toshihide Yamashita
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Journal Title
Nature Aging
Volume: 1
Issue: 3
Pages: 284-294
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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