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Study on ECG automatic analysis technology and its clinical usefulness based on artificial intelligence and cardiac simulation

Research Project

Project/Area Number 18K11532
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 62010:Life, health and medical informatics-related
Research InstitutionThe University of Aizu

Principal Investigator

ZHU XIN  会津大学, コンピュータ理工学部, 上級准教授 (70448645)

Co-Investigator(Kenkyū-buntansha) 野呂 眞人  東邦大学, 医学部, 臨床教授 (10366495)
中村 啓二郎  東邦大学, 医学部, 助教 (20366181)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords心電図 / 深層学習 / 不整脈 / 心臓モデル / 人工知能 / シミュレーション / 敵対的生成ネットワーク / 心房細動 / 早期収縮 / 心臓シミュレーション / 自動解析 / 臨床有用性
Outline of Final Research Achievements

In this research, we propose two method to synthesize simulation ECG for the development of automatic ECG interpretation algorithms. At first, we constructed cardiac models to synthesize simulation ECG. Secondly, we used clinical ECG data to synthesize ECG using anniversary neural networks. Then, we added Physionet Open database to construct the database for the training and testing of deep neural networks. Based on deep learning, we proposed ECG noise recognition algorithm, atrial fibrillation detection algorithm, QT interval measurement algorithm, and obstructive sleep apnea detection algorithm. These algorithms demonstrate better performance compared with traditional methods.

Academic Significance and Societal Importance of the Research Achievements

本研究は、心臓モデル、対抗ニューラルネットワークを用い、深層ニューラルネットワークの学習・テスト用の心電図を合成し、より少ないデータで心電図自動解析アルゴリズムを開発できた。開発した心電図からノイズの識別アルゴリズム、心房細動心電図波形の検出アルゴリズム、QT間隔の自動計測アルゴリズム、閉塞性睡眠時無呼吸の自動検出アルゴリズムはいずれも高い臨床価値があり、心疾患の早期診断・治療に役立て、国民の健康増進、医療費の低減に貢献できると考えられる。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (18 results)

All 2021 2020 2019 2018 Other

All Int'l Joint Research (1 results) Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 2 results) Presentation (12 results) (of which Int'l Joint Research: 7 results) Remarks (2 results)

  • [Int'l Joint Research] 上海大学(中国)

    • Related Report
      2018 Research-status Report
  • [Journal Article] A fused-image-based approach to detect obstructive sleep apnea using a single-lead ECG and a 2D convolutional neural network2021

    • Author(s)
      Niroshana S. M. Isuru、Zhu Xin、Nakamura Keijiro、Chen Wenxi
    • Journal Title

      PLOS ONE

      Volume: 16 Issue: 4 Pages: e0250618-e0250618

    • DOI

      10.1371/journal.pone.0250618

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] An Arrhythmic Mutation E7K Facilitates TRPM4 Channel Activation via Enhanced PIP2 Interaction2021

    • Author(s)
      Hu Yaopeng、Li Qin、Kurahara Lin-Hai、Shioi Narumi、Hiraishi Keizo、Fujita Takayuki、Zhu Xin、Inoue Ryuji
    • Journal Title

      Cells

      Volume: 10 Issue: 5 Pages: 983-983

    • DOI

      10.3390/cells10050983

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Single-channel ECG suitable for ECG-derived respiration2019

    • Author(s)
      Motoki Sakai, Rei Sekine and Xin Zhu
    • Journal Title

      Biomedical Physics & Engineering Express

      Volume: 5 Issue: 5 Pages: 1-12

    • DOI

      10.1088/2057-1976/ab32bb

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Presentation] Effects of Myocardial Fat’s Thickness and Myocardial Impedance on Bipolar Radiofrequency Cathode Ablation2020

    • Author(s)
      Yao Sun; Xin Zhu; Keijiro Nakamura
    • Organizer
      2020 IEEE REGION 10 CONFERENCE (TENCON)
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Determination of T Wave End by Multi-input Deep Learning Model2020

    • Author(s)
      Xue Zhou; Xin Zhu; Keijiro Nakamura; Mahito Noro
    • Organizer
      2020 IEEE 5th International Conference on Signal and Image Processing (ICSIP)
    • Related Report
      2020 Annual Research Report
  • [Presentation] ECG quality assessment based on convolutional neural network-long-short term memory and generative adversarial network2020

    • Author(s)
      Xin Zhu; Xue Zhou; Keiichiro Nakamura; Mahito Noro
    • Organizer
      心電学関連研究会2020
    • Related Report
      2020 Annual Research Report
  • [Presentation] 敵対的生成ネットワークによる心電図雑音評価効果の改善2019

    • Author(s)
      朱欣
    • Organizer
      第39回日本ホルター・ノンイベシブ心電学研究会
    • Related Report
      2019 Research-status Report
  • [Presentation] Study on defibrillation of automatic external defibrillator using computer simulation2019

    • Author(s)
      朱欣
    • Organizer
      第34回心電情報処理ワークショップ
    • Related Report
      2019 Research-status Report
  • [Presentation] Difficulty in Differentiating Takotsubo syndrome from Multiple Vasospastic Angina (case report)2019

    • Author(s)
      Shunsuke Todani, Mao Takahashi, Mahito Noro
    • Organizer
      APSC 2019
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Relapse of stress-induced cardiomyopathy gradually decreased cardiac function (case report)2018

    • Author(s)
      Shunsuke Todani, Mao Takahashi, Mahito Noro
    • Organizer
      APSC 2019
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Atrial Fibrillation Detection Using Convolutional Neural Networks2018

    • Author(s)
      Xue Zhou, Xin Zhu, Keiichiro Nakamura, and Mahito Noro
    • Organizer
      The 9th IEEE International Conference on Awareness Science and Technology
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] ECG Quality Assessment Using 1D-Convolutional Neural Network2018

    • Author(s)
      Xue Zhou, Xin Zhu, Keiichiro Nakamura, and Mahito Noro
    • Organizer
      The 14th IEEE International Conference on Signal Processing
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Premature Ventricular Contraction Detection from Ambulatory ECG Using Recurrent Neural Networks2018

    • Author(s)
      Xue Zhou, Xin Zhu, Keiichiro Nakamura, and Mahito Noro
    • Organizer
      40th IEEE EMBC annual Conference
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Detect Atrial Fibrillation Using Deep Learning2018

    • Author(s)
      Xue Zhou, Xin Zhu, Keiichiro Nakamura, and Mahito Noro
    • Organizer
      the 33rd Annual Conference of the Japanese Society for Computerized Electrocardiology
    • Related Report
      2018 Research-status Report
  • [Presentation] Detect the Premature Ventricular Contraction Using Recurrent Neural Networks2018

    • Author(s)
      Xue Zhou, Xin Zhu, Keiichiro Nakamura, and Mahito Noro
    • Organizer
      the 45th Congress of the International Society of Electrocardiology
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Remarks] Biomedical Information Technology Lab

    • URL

      http://bitlab.u-aizu.ac.jp/

    • Related Report
      2020 Annual Research Report
  • [Remarks] 会津大学生体医用情報工学講座

    • URL

      http://bitlab.u-aizu.ac.jp/?page_id=8

    • Related Report
      2019 Research-status Report

URL: 

Published: 2018-04-23   Modified: 2022-01-27  

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