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Clarification of pathophysiology of sleep disorders associated with neurological disorders based on mathematical analysis of polysomnography data

Research Project

Project/Area Number 18K11539
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 62010:Life, health and medical informatics-related
Research InstitutionKwansei Gakuin University

Principal Investigator

YOSHINO Kohzoh  関西学院大学, 生命環境学部, 教授 (10358343)

Co-Investigator(Kenkyū-buntansha) 猪山 昭徳  独立行政法人国立病院機構大阪刀根山医療センター(臨床研究部), 独立行政法人国立病院機構大阪刀根山医療センター, 研究員(移行) (40645313)
Project Period (FY) 2018-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords筋委縮性側索硬化症 / パーキンソン病 / 睡眠 / 自律神経 / 睡眠時無呼吸症候群 / 睡眠段階 / 心拍数 / 睡眠ポリグラフ / 筋萎縮性側索硬化症 / 動脈血酸素飽和度 / 脳波 / 睡眠時無呼吸障害 / 心拍変動 / 気流 / 生理信号 / 無呼吸 / 神経変性疾患
Outline of Final Research Achievements

We analyzed the sleep polysomnography data from neurodegenerative disease patients having concomitant sleep apnea syndrome (SAS). (1) We showed the difference in the dynamics of oxyhemoglobin saturation (SpO2) between amyotrophic lateral sclerosis (ALS) with SAS and non-ALS patients with SAS. The decreasing speed of SpO2 in the case of ALS with SAS patients was significantly slower than those of the non-ALS with SAS patients. (2) We showed that normalized transition probability and transition rate from REM to Wake and from Wake to REM in PD patients with SAS were significantly lower than those in the non-PD patients with SAS. Moreover, the Wake and REM stages of PD patients with SAS were significantly more likely to continue than those of the non-PD patients with SAS. (3) We showed that the amplitude of increase in the heart rate in response to obstructive apnea/hypopnea events was significantly lower for patients in the PD group with SAS than those of the non-PD group with SAS.

Academic Significance and Societal Importance of the Research Achievements

本研究は,筋委縮性側索硬化症(ALS)患者とパーキンソン病(PD)患者にとって自覚しにくい非運動症状(睡眠関連疾患,自律神経障害)の特徴量を明らかにした.これらの疾患では,自覚可能な運動症状よりも非運動症状が先行して生じる場合があり,同定した特徴量を活用することにより,ALSやPD等の神経変性疾患の早期スクリーニングに応用できる可能性があり,学術的にも社会的にも意義が高い.

Report

(6 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (14 results)

All 2022 2021 2020 2018

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (11 results) (of which Int'l Joint Research: 1 results) Book (1 results)

  • [Journal Article] Dynamic sleep stage transition process analysis in patients with Parkinson's disease having sleep apnea syndrome2021

    • Author(s)
      Yoshino Kohzoh、Inomoto Saki、Iyama Akinori、Sakoda Saburo
    • Journal Title

      Informatics in Medicine Unlocked

      Volume: 25 Pages: 100656-100656

    • DOI

      10.1016/j.imu.2021.100656

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Analysis of heart rate response to obstructive apnea/hypopnea events in patients with Parkinson's disease with relatively severe sleep apnea syndrome2021

    • Author(s)
      Yoshino Kohzoh、Kawaguchi Ayano、Yata Shogo、Iyama Akinori、Sakoda Saburo
    • Journal Title

      Informatics in Medicine Unlocked

      Volume: 23 Pages: 100554-100554

    • DOI

      10.1016/j.imu.2021.100554

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] パーキンソン病患者の睡眠時閉塞性呼吸イベントに対する心拍応答の要因解析2022

    • Author(s)
      中尾有希,猪山昭徳,佐古田三郎,吉野公三
    • Organizer
      第61回日本生体医工学会大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 睡眠時無呼吸イベント自動検知アルゴリズムの開発2022

    • Author(s)
      赤松秀一,猪山昭徳,玉元由果莉,藤江建朗,中村英夫,佐古田三郎,吉野公三
    • Organizer
      第61回日本生体医工学会大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] パーキンソン病が睡眠時無呼吸症候群患者の睡眠段階遷移過程に与える影響2022

    • Author(s)
      吉野公三,猪本咲希,猪山昭徳,佐古田三郎
    • Organizer
      計測自動制御学会ライフエンジニアリング部門シンポジウム2022(LE2022)
    • Related Report
      2022 Annual Research Report
  • [Presentation] 閉塞性睡眠時無呼吸症候群を併発するパーキンソン病患者の動的睡眠段階遷移過程解析2022

    • Author(s)
      吉野公三,猪本咲希,猪山昭徳,野々上茂,佐古田三郎
    • Organizer
      第13回日本臨床睡眠医学会学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 睡眠時無呼吸症候群を併発するパーキンソン病患者の脳波のサンプルエントロピー解析2021

    • Author(s)
      石橋拓巳,猪山昭徳,佐古田三郎,吉野公三
    • Organizer
      第60回日本生体医工学会大会
    • Related Report
      2021 Research-status Report
  • [Presentation] 閉塞性睡眠時無呼吸症候群を伴うパーキンソン病における呼吸イベントに対する心拍応答の解析2021

    • Author(s)
      吉野公三,川口綾乃,矢田翔梧,猪山昭徳,佐古田三郎
    • Organizer
      第12回日本臨床睡眠医学会学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] パーキンソン病患者の睡眠脳波の不規則性解析2021

    • Author(s)
      石橋拓巳,猪山昭徳,佐古田三郎,吉野公三
    • Organizer
      2021年度統計数理研究所共同研究集会「健康・医療情報学,生体計測・生体信号解析とその周辺2」
    • Related Report
      2021 Research-status Report
  • [Presentation] パーキンソン病患者の睡眠時自律神経活動解析2021

    • Author(s)
      吉野公三,川口綾乃,矢田翔梧,藤原未沙貴,元梅璃奈,猪山昭徳,佐古田三郎
    • Organizer
      2021年度統計数理研究所共同研究集会「健康・医療情報学,生体計測・生体信号解析とその周辺2」
    • Related Report
      2021 Research-status Report
  • [Presentation] 睡眠時無呼吸障害を併発するパーキンソン病患者の心拍応答解析2020

    • Author(s)
      吉野公三,川口綾乃,矢田翔梧,猪山昭徳,佐古田三郎
    • Organizer
      第59回日本生体医工学会大会
    • Related Report
      2020 Research-status Report
  • [Presentation] Analysis of heart rate response to sleep apnea events in patients with Parkinson's disease2018

    • Author(s)
      Yata S, Iyama A, Sakoda S, Yoshino K
    • Organizer
      IEEE-BIBM2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 睡眠時無呼吸症候群を併発するパーキンソン病患者の動的睡眠段階遷移過程2018

    • Author(s)
      猪本咲希,猪山昭徳,佐古田三郎,吉野公三
    • Organizer
      第57回日本生体医工学会大会
    • Related Report
      2018 Research-status Report
  • [Book] 「生体情報センシングと人の状態推定への応用」の6.3節「生体信号の数理解析に基づく心身の状態評価」2020

    • Author(s)
      吉野公三(分担)
    • Total Pages
      564
    • Publisher
      技術情報協会
    • Related Report
      2020 Research-status Report

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Published: 2018-04-23   Modified: 2024-01-30  

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