| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
The DNA damage response is critical for cells to prevent from genotoxic stress such as DNA damage. ATR kinase is one of the central players in this system. ATR makes a complex with ATRIP, activated under DNA replication stress by two independent mechanisms. To identify novel ATR-ATRIP activation pathway, we undertook siRNA screening against mitomycin C and hydroxy urea treated ATRIP-GFP expressing cells by evaluating both ATRIP and RPA2 foci formation efficiency. We obtained 29 candidate genes. We further evaluate these candidates.
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