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Development of a stochastic DNA damage model with a molecular dynamics calculation

Research Project

Project/Area Number 18K11650
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 63020:Radiation influence-related
Research InstitutionNational Institute of Technology, Toyama College

Principal Investigator

Aso Tsukasa  富山高等専門学校, その他部局等, 教授 (30290737)

Co-Investigator(Kenkyū-buntansha) 原 正憲  富山大学, 学術研究部理学系, 准教授 (00334714)
藤原 進  京都工芸繊維大学, 材料化学系, 教授 (30280598)
平野 祥之  名古屋大学, 医学系研究科(保健), 准教授 (00423129)
Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsモンテカルロシミュレーション / Geant4-DNA / トリチウム / 分子動力学計算 / 量子力学計算 / モンテカルロ法 / DNA損傷 / モンテカルロ計算 / DNA / Geant4 / シミュレーション / 分子化学
Outline of Final Research Achievements

In this study, a Monte Carlo simulation framework based on Geant4-DNA was developed, for the purpose of evaluating DNA damages by using a stochastic model. The simulation imports DNA models from the proton data bank and is capable of simulating both the direct and the indirect DNA damages. We focused on tritium-induced DNA damages and verified that the ratio of single-strand breaks to double-strand breaks is consistent with the results of previous studies.

Academic Significance and Societal Importance of the Research Achievements

トリチウムは、原子力発電施設の処理水に含まれており除去が不可能な放射性元素です。本研究ではトリチウムの内部被曝を評価することを目指して、その発端となるDNA損傷が生じる可能性を評価するためのシミュレーションを開発しました。DNA損傷には、放射線が直接影響を与える直接作用と、放射線により生じたラジカルが与える間接作用があります。シミュレーションは、これらの作用の割合等を求めることができます。将来的に、例えば間接作用を低減させる放射防護剤などの検討評価などへの応用が期待されます。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (7 results)

All 2021 2019 2018

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (6 results) (of which Int'l Joint Research: 3 results,  Invited: 2 results)

  • [Journal Article] Galet - Geant4 Based Application Templet for Primers2019

    • Author(s)
      T. Aso, W. Takase, T. Sasaki
    • Journal Title

      Transactions on GIGAKU e-journal

      Volume: 印刷中 Pages: 1-11

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Geant4-DNA Based Monte Carlo Simulation to Study Tritium-induced DNA Damage2021

    • Author(s)
      T. Aso, Y. Hirano, M. Hara, S. Fujiwara
    • Organizer
      IEEE Nuclear Science Symposium and Medical Imaging Conference
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 重水へ溶解させたグリシンへのガンマ線照射と重水素置換2021

    • Author(s)
      原正憲, 阿蘇司, 大矢恭久
    • Organizer
      第58回アイソトープ・放射線研究発表会
    • Related Report
      2020 Research-status Report
  • [Presentation] Geant4-DNA based Monte Carlo simulation and its prospects to verify DNA-level experiments2019

    • Author(s)
      T. Aso, M. Hara, S. Fujiwara, Y. Hirano
    • Organizer
      International Symposium on Radiation Safety and Detection Technology (ISORD-10)
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Geant4-DNAを用いたDNA損傷モデル評価のためのシミュレーション開発2019

    • Author(s)
      阿蘇司, 岡本雅生
    • Organizer
      日本物理学会北陸支部定例学術講演会
    • Related Report
      2019 Research-status Report
  • [Presentation] モンテカルロシミュレーションツールキットとそのアプリケーション開発例2019

    • Author(s)
      阿蘇司
    • Organizer
      日本原子力学会「2019年秋の大会」
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] Introduction to Geant4 and Geant4-DNA2018

    • Author(s)
      T.Aso, S.Okada, T.Sasaki
    • Organizer
      The 37th JSST Annual International Conference on Simulation Technology
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited

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Published: 2018-04-23   Modified: 2023-01-30  

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