Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Outline of Final Research Achievements |
Carcinogenic risk from low-dose radiation exposure is an important issue that must be scientifically clarified, and stem cells are considered to be the origin of radiation carcinogenesis. Therefore, in this study, we set up a cell lineage tracing experiment that can trace stem cells and their progenies and a three-dimensional immunohistochemical analysis in combination with tissue clearing. Using these techniques, we observed relatively early cell dynamics after radiation exposure. We could evaluate the presence of labeled stem cells and whether they were proliferating or not. This suggests the possibility of observing the effects of radiation exposure on mammary stem cells.
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