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Evaluation of size distribution and toxicity of atmospheric polycyclic aromatic hydrocarbon quinones generating reactive oxygen species

Research Project

Project/Area Number 18K11676
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 64010:Environmental load and risk assessment-related
Research InstitutionNagasaki University (2020-2021)
Kanazawa University (2018-2019)

Principal Investigator

Toriba Akira  長崎大学, 医歯薬学総合研究科(薬学系), 教授 (50313680)

Co-Investigator(Kenkyū-buntansha) 古内 正美  金沢大学, 地球社会基盤学系, 教授 (70165463)
唐 寧  金沢大学, 環日本海域環境研究センター, 教授 (90372490)
Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords多環芳香族炭化水素 / 大気汚染 / 粒子状物質 / ナノ粒子 / 粒径分布 / 活性酸素 / 酸化ストレス
Outline of Final Research Achievements

Nanoparticles (PM0.1) with a particle size smaller than 0.1 μm were collected at two sites in Japan, and the particle size distribution and sources of polycyclic aromatic hydrocarbon quinones (PAHQs) were analyzed. The results showed that the highest concentrations of PAHQ were distributed in nanoparticles, indicating that PAHQ exposure via nanoparticles may really occur. Secondary formation in the atmosphere and automobile emissions were found to be the major sources of PAHQ. Furthermore, the dithiothreitol (DTT) assay was carried out to determine the ability of generating reactive oxygen species (ROS) of each particle size fraction. The results showed that the smaller particle size had the higher the ROS production ability, and the contribution of PAHQ to it was about 10%, suggesting that the toxicity of nanoparticles may be stronger than that of larger particle size fractions.

Academic Significance and Societal Importance of the Research Achievements

活性酸素(ROS)を生成して循環器疾患やアレルギー疾患,喘息等を増悪させる可能性がある多環芳香族炭化水素キノン(PAHQ)類は,大気汚染実態が不明な有機汚染物質であり,微量でも急性影響を示す可能性がある。本研究により,都市大気におけるPAHQのナノ粒子を含む粒径分布,環境動態や発生源,各粒径ごとのROS産生毒性に対する寄与度が初めて明らかとなり,粒径ごとのPAHQ濃度とROS産生に関する毒性との関係が明確になった。得られた成果は健康影響の観点でPM2.5に含まれるより微細な粒子(ナノ粒子)の健康影響の議論や,環境基準などによる規制の必要性に関する判断材料に成り得る。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (34 results)

All 2022 2021 2020 2019 2018 Other

All Int'l Joint Research (5 results) Journal Article (11 results) (of which Int'l Joint Research: 8 results,  Peer Reviewed: 11 results,  Open Access: 9 results) Presentation (18 results) (of which Int'l Joint Research: 1 results,  Invited: 3 results)

  • [Int'l Joint Research] チェンマイ大学/タマサート大学/メジョー大学(タイ)

    • Related Report
      2020 Research-status Report
  • [Int'l Joint Research] ベトナム国家農業大学/ハノイ工科大学(ベトナム)

    • Related Report
      2019 Research-status Report
  • [Int'l Joint Research] チェンマイ大学/タマサート大学/メジョー大学(タイ)

    • Related Report
      2019 Research-status Report
  • [Int'l Joint Research] ベトナム国家農業大学/ハノイ工科大学(ベトナム)

    • Related Report
      2018 Research-status Report
  • [Int'l Joint Research] チェンマイ大学/タマサート大学/メジョー大学(タイ)

    • Related Report
      2018 Research-status Report
  • [Journal Article] Long-Term and Seasonal Changes in Sources of Urban Atmospheric Particulates in the Western Pacific2022

    • Author(s)
      Hayakawa Kazuichi、Tang Ning、Toriba Akira
    • Journal Title

      Applied Sciences

      Volume: 12 Issue: 4 Pages: 2149-2149

    • DOI

      10.3390/app12042149

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Emission factors of selected air pollutants from rice straw burning in Hanoi, Vietnam2021

    • Author(s)
      Pham Chau-Thuy、Ly Bich-Thuy、Nghiem Trung-Dung、Pham Thi Hong-Phuong、Minh Nguyen-Thi、Tang Ning、Hayakawa Kazuichi、Toriba Akira
    • Journal Title

      Air Quality, Atmosphere and Health

      Volume: 14 Issue: 11 Pages: 1757-1771

    • DOI

      10.1007/s11869-021-01050-6

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Polycyclic aromatic hydrocarbons and nitro-polycyclic aromatic hydrocarbons in five East Asian cities: Seasonal characteristics, health risks, and yearly variations2021

    • Author(s)
      Yang Lu、Zhang Lulu、Chen Lijiang、Han Chong、Akutagawa Tomoko、Endo Osamu、Yamauchi Masahito、Neroda Andrey、Toriba Akira、Tang Ning
    • Journal Title

      Environmental Pollution

      Volume: 287 Pages: 117360-117360

    • DOI

      10.1016/j.envpol.2021.117360

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Calculating source contributions to urban atmospheric polycyclic aromatic hydrocarbons and nitropolycyclic aromatic hydrocarbons using 1-nitropyrene and pyrene: An application to an Asian dust event2021

    • Author(s)
      Hayakawa Kazuichi、Tang Ning、Matsuki Atsushi、Inomata Yayoi、Toriba Akira、Nagato Edward G.
    • Journal Title

      Chemosphere

      Volume: 280 Pages: 130662-130662

    • DOI

      10.1016/j.chemosphere.2021.130662

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Urinary 1-aminopyrene level in Koreans as a biomarker for the amount of exposure to atmospheric 1-nitropyrene2021

    • Author(s)
      Ochirpurev Bolormaa、Eom Sang-Yong、Toriba Akira、Kim Yong-Dae、Kim Heon
    • Journal Title

      Toxicological Research

      Volume: - Issue: 1 Pages: 45-51

    • DOI

      10.1007/s43188-021-00096-z

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] What is necessary for next‐generation atmospheric environmental standards? Recent research trends for PM2.5‐bound polycyclic aromatic hydrocarbons and their derivatives2020

    • Author(s)
      Toriba Akira、Hayakawa Kazuichi
    • Journal Title

      Biomedical Chromatography

      Volume: 35 Issue: 1

    • DOI

      10.1002/bmc.5038

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Calculating sources of combustion-derived particulates using 1-nitropyrene and pyrene as markers2020

    • Author(s)
      Hayakawa Kazuichi、Tang Ning、Toriba Akira、Nagato Edward G.
    • Journal Title

      Environmental Pollution

      Volume: in press Pages: 114730-114730

    • DOI

      10.1016/j.envpol.2020.114730

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Quantification of Hydroxylated Polycyclic Aromatic Hydrocarbons in Airborne Particulate Matter by GC/MS2019

    • Author(s)
      Toriba Akira、Kasahara Chieko、Bekki Kanae、Samizo Masayuki、Tang Ning、Hayakawa Kazuichi
    • Journal Title

      BUNSEKI KAGAKU

      Volume: 68 Issue: 11 Pages: 839-845

    • DOI

      10.2116/bunsekikagaku.68.839

    • NAID

      130007759826

    • ISSN
      0525-1931
    • Year and Date
      2019-11-05
    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Emission Characteristics of Polycyclic Aromatic Hydrocarbons and Nitro-Polycyclic Aromatic Hydrocarbons from Open Burning of Rice Straw in the North of Vietnam2019

    • Author(s)
      Pham Chau-Thuy、Boongla Yaowatat、Nghiem Trung-Dung、Le Huu-Tuyen、Tang Ning、Toriba Akira、Hayakawa Kazuichi
    • Journal Title

      International Journal of Environmental Research and Public Health

      Volume: 16 Issue: 13 Pages: 2343-2343

    • DOI

      10.3390/ijerph16132343

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Investigation of Inflammation Inducing Substances in PM2.5 Particles by an Elimination Method Using Thermal Decomposition2019

    • Author(s)
      He Miao、Ichinose Takamichi、Ito Tomohiro、Toriba Akira、Yoshida Seiichi、Kaori Sadakane、Nishikawa Masataka、Sun Guifan、Shibamoto Takayuki
    • Journal Title

      Environmental Toxicology

      Volume: 34 Issue: 10 Pages: 1137-1148

    • DOI

      10.1002/tox.22816

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Identification of Long-Range Transported Polycyclic Aromatic Hydrocarbons in Snow at Mt. Tateyama, Japan2018

    • Author(s)
      Hayakawa Kazuichi、Tang Ning、Nagato Edward G.、Toriba Akira、Aoki Kazuma
    • Journal Title

      Aerosol and Air Quality Research

      Volume: 印刷中 Issue: 6 Pages: 1252-1258

    • DOI

      10.4209/aaqr.2018.05.0153

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 中国の新型コロナウイルス感染症流行期間中に輪島で観測された越境輸送大気汚染物質の変化2022

    • Author(s)
      張 昊、張 セン、王 エン、白 ポウソウ、張露露、早川 和一、鳥羽 陽、唐 寧
    • Organizer
      日本薬学会142年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 大気粒子及び燃焼発生源粒子中の多環芳香族炭化水素キノン類の分析と粒子酸化能への寄与2022

    • Author(s)
      鳥羽 陽
    • Organizer
      第67回金沢大学環日本海域環境研センターセミナー
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 大気粉塵中多環芳香族炭化水素キノン類の発生源解析2021

    • Author(s)
      鳥羽 陽,本間千春,唐 寧,早川和一
    • Organizer
      フォーラム2021:衛生薬学・環境トキシコロジー
    • Related Report
      2021 Annual Research Report
  • [Presentation] 大気粒子及び燃焼発生源粒子の酸化能に対する多環芳香族炭化水素キノン類の寄与2021

    • Author(s)
      鳥羽 陽
    • Organizer
      大気環境学会近畿支部反応と測定部会講演会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 大気粒子抽出物の酸化能測定の最適化と粒径別実大気試料の評価2021

    • Author(s)
      鳥羽 陽,森井彩香,本間千春,唐寧, 早川和一
    • Organizer
      日本薬学会141年会
    • Related Report
      2020 Research-status Report
  • [Presentation] アジアの都市域における大気中多環芳香族炭化水素の特徴及び健康リスク評価2020

    • Author(s)
      楊 露,張 露露,張 昊,周 全渝,張 旋,刑 万里,鳥羽 陽,早川和一,柏倉桐子,呉 慶,周 志俊,陳 仁杰,Heon Kim,Vassily Mishukov,Andrey Neroda,唐 寧
    • Organizer
      第61回 大気環境学会年会
    • Related Report
      2020 Research-status Report
  • [Presentation] タイ農村の屋内バイオマス燃焼に由来する多環芳香族炭化水素類の特性解析2020

    • Author(s)
      鳥羽 陽,Walaiporn Orakij,Thaneeya Chetiyanukornkul,唐 寧,早川和一
    • Organizer
      第61回 大気環境学会年会
    • Related Report
      2020 Research-status Report
  • [Presentation] 大気粒子及び燃焼発生源粒子の酸化能に対する多環芳香族炭化水素キノン類の寄与評価2020

    • Author(s)
      川井 萌,寺村優希,本間千春,山崎 陸,唐 寧,早川和一,鈴木 亮,鳥羽 陽
    • Organizer
      日本薬学会140年会
    • Related Report
      2019 Research-status Report
  • [Presentation] 個人サンプラーによる大気中ガス状多環芳香族炭化水素類の捕集方法の開発2019

    • Author(s)
      鳥羽 陽,氣谷広登,佐々木智啓
    • Organizer
      2019年室内環境学会学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] 大気粒子による活性酸素種産生に対する多環芳香族炭化水素キノン類の寄与評価2019

    • Author(s)
      鳥羽 陽、寺村優希,森井彩香,川井 萌,深川真夢,本間千春,唐寧, 早川和一
    • Organizer
      第60回大気環境学会
    • Related Report
      2019 Research-status Report
  • [Presentation] タイのタクシー車内におけるPM2.5曝露と粒子中の多環芳香族炭化水素類の特徴2019

    • Author(s)
      鳥羽 陽,長岡 祐樹,深川 真夢,Thaneeya Chetiyanukornkul,唐 寧,早川 和一
    • Organizer
      フォーラム2019:衛生薬学・環境トキシコロジー
    • Related Report
      2019 Research-status Report
  • [Presentation] タイにおいて捕集された自動車排ガス由来のPM2.5に含まれる多環芳香族炭化水素類の分析2019

    • Author(s)
      鳥羽 陽,長岡 祐樹,深川 真夢,Thaneeya Chetiyanukornkul,唐 寧,早川 和一
    • Organizer
      第28回環境化学討論会
    • Related Report
      2019 Research-status Report
  • [Presentation] 大気中の粒子状物質に含まれる多環芳香族炭化水素及びその誘導体の粒径分布評価2019

    • Author(s)
      鳥羽陽,深川 真夢,長岡 祐樹,本間千春,唐寧,早川和一
    • Organizer
      日本薬学会139年会
    • Related Report
      2018 Research-status Report
  • [Presentation] 分散固相抽出法を用いた蛍光検出-HPLC によるニトロ多環芳香族炭化水素類の簡易一斉分析法の開発2018

    • Author(s)
      尾田知之,唐 寧,早川和一,鈴木亮,鳥羽陽
    • Organizer
      日本薬学会北陸支部第130回例会
    • Related Report
      2018 Research-status Report
  • [Presentation] 都市大気環境における粒子状多環芳香族炭化水素キノン類の粒径分布解析2018

    • Author(s)
      鳥羽陽,深川正夢,本間千春,唐寧,早川和一
    • Organizer
      第59回大気環境学会
    • Related Report
      2018 Research-status Report
  • [Presentation] Development of a urinary biomarker to evaluate exposure to metabolites of 9, 10-phenanthrenequinone associated with producing reactive oxygen species2018

    • Author(s)
      Toriba, A.
    • Organizer
      8th International Forum on Green Technology and Management
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 大気粒子の粒径別酸化能測定と多環芳香族炭化水素キノン類の寄与2018

    • Author(s)
      鳥羽 陽,森井 彩香,本間 千春,唐 寧,早川 和一
    • Organizer
      フォーラム2018:衛生薬学・環境トキシコロジー
    • Related Report
      2018 Research-status Report
  • [Presentation] 世界の大気汚染を多環芳香族炭化水素類から比較する2018

    • Author(s)
      早川 和一,長門Edward 豪,唐 寧,鳥羽 陽
    • Organizer
      フォーラム2018:衛生薬学・環境トキシコロジー
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2023-01-30  

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