Quality diagnosis of oocytes by the birefringence imaging of zona pellucida.
| Project/Area Number |
18K12042
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 90110:Biomedical engineering-related
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| Research Institution | Nihon University |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 卵子品質 / 透明帯 / 複屈折 / 卵子 / 未受精卵 / 複屈折率 / 体外成熟 / 透明帯硬化 |
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| Outline of Final Research Achievements |
The purpose of this study is to clarify the changes in the birefringence of the oocyte zona pellucida during the maturation process of oocytes, and to propose a nobel diagnostic method for oocyte quality. In this study, the birefringence of the zona pellucida of oocytes was quantitatively measured using a transmission laser microscope, suggesting the possibility of evaluating the quality of unfertilized eggs.
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| Academic Significance and Societal Importance of the Research Achievements |
品質の良い体外受精卵を得るためには，活力ある精子と品質の良い卵子が必要である．本研究成果は，形態学的な見た目による卵子品質の評価に変わり，定量的に卵子の品質を診断できる可能性を秘めており，ヒト生殖補助医療への応用が十分に期待される．
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Report
(4 results)
Research Products
(4 results)
