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Development of basic technologies for wearable biomagnetic measurement

Research Project

Project/Area Number 18K12044
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 90110:Biomedical engineering-related
Research InstitutionKanazawa Institute of Technology

Principal Investigator

Adachi Yoshiaki  金沢工業大学, 先端電子技術応用研究所, 教授 (80308585)

Co-Investigator(Kenkyū-buntansha) 川端 茂徳  東京医科歯科大学, 大学院医歯学総合研究科, ジョイントリサーチ講座教授 (50396975)
Project Period (FY) 2018-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords磁気センサ / 生体磁気 / 生体磁気計測
Outline of Final Research Achievements

Recently, the performance of room-temperature (RT) magnetic flux sensors has improved, and we have developed the necessary elemental technologies for realizing wearable biomagnetic measurement using these sensors. Specifically, we established a calibration method for the position, orientation, and sensitivity of the RT magnetic flux sensors, and improved the magnetic field source analysis for scenarios where the magnetic field source is in the vicinity of the sensor, using a multiple-sensitivity point model of the sensitivity region of the RT magnetic flux sensor. We also developed a triangular marker coil that dynamically reveals the relative position between the sensors and the subject. We proposed a method to reduce subject-movement noise through adaptive baseline correction. Furthermore, we successfully performed simultaneous measurement of muscle magnetic fields with a RT magnetic flux sensor array fixed on the body surface with a gel cushion as well as a SQUID sensor array.

Academic Significance and Societal Importance of the Research Achievements

生体磁気計測は、体外に配置した磁気センサで体内の電気的活動に伴う微弱な磁場を検出し、無侵襲で神経や筋肉の活動を観察するものである。近年、フラックスゲートや磁気抵抗効果を利用した室温で動作する磁気センサの性能が向上し、それらのセンサを適用したウエアラブルな生体磁気計測の提案がなされている。ウエアラブル生体磁気計測が実現すれば、運動中の筋肉活動の観測も無侵襲で可能となり、スポーツ科学などへの応用が期待できる。
本研究ではウエアラブル生体磁気計測が直面する課題、すなわち磁気センサ自体の物理的な揺れに伴う揺動ノイズの低減と、磁気センサと体表面の相対位置の動的検知という2つの課題の解決に取り組んだ。

Report

(6 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (39 results)

All 2023 2022 2021 2020 2019 2018

All Journal Article (12 results) (of which Peer Reviewed: 8 results,  Open Access: 6 results) Presentation (24 results) (of which Int'l Joint Research: 12 results,  Invited: 11 results) Book (1 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Dry-type phantom emulating quadrupole-like magnetic field distribution for evaluation of magnetoneurography2023

    • Author(s)
      Yoshiaki Adachi, Daisuke Oyama, Gen Uehara, Shigenori Kawabata
    • Journal Title

      IEEE Transactions on Magnetics

      Volume: - Issue: 11 Pages: 1-5

    • DOI

      10.1109/tmag.2023.3278745

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Simultaneous recording of biomagnetic signals using SQUIDs and relocatable room-temperature flux sensors2023

    • Author(s)
      Yoshiaki Adachi, Shigenori Kawabata
    • Journal Title

      日本生体磁気学会誌

      Volume: 36

    • Related Report
      2022 Annual Research Report
  • [Journal Article] A Spherical Coil Array for the Calibration of Whole-Head Magnetoencephalograph Systems2023

    • Author(s)
      Yoshiaki Adachi, Daisuke Oyama, Masanori Higuchi, Gen Uehara
    • Journal Title

      IEEE Transactions on Instrumentation and Measurement

      Volume: 72 Pages: 1-10

    • DOI

      10.1109/tim.2023.3265750

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 複数感度点モデルによるSQUID生体磁気計測のマーカーコイル位置推定精度の改善2022

    • Author(s)
      足立善昭, 高橋陽一郎, 内城禎久, 後藤一磨, 春田康博
    • Journal Title

      日本生体磁気学会誌

      Volume: 35 Pages: 136-137

    • Related Report
      2022 Annual Research Report
  • [Journal Article] Emerging MR sensors for biomagnetic measurements2022

    • Author(s)
      Yoshiaki Adachi, Shigenori Kawabata, Tetsuo Tatsuoka, Yasushi Terazono
    • Journal Title

      Flexible High Performance Magnetic Field Sensors: On-Scalp Magnetoencephalography and Other Applications, Eds. Etienne Labyt, Tilmann Sander-Thommes, Ronald Wakai, Springer Cham

      Volume: - Pages: 299-312

    • DOI

      10.1007/978-3-031-05363-4_16

    • ISBN
      9783031053627, 9783031053634
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of a magnetoneurograph system2021

    • Author(s)
      足立善昭
    • Journal Title

      Japanese Journal of Clinical Neurophysiology

      Volume: 49 Issue: 6 Pages: 482-489

    • DOI

      10.11422/jscn.49.482

    • NAID

      130008132039

    • ISSN
      1345-7101, 2188-031X
    • Year and Date
      2021-12-01
    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Evaluation of Directional Dependence of Sensitivity for Room-Temperature Magnetic Flux Sensors With Wide Sensitivity Region2021

    • Author(s)
      Adachi Yoshiaki、Mizuhara Yuki、Terazono Yasushi
    • Journal Title

      IEEE Transactions on Magnetics

      Volume: 57 Issue: 2 Pages: 1-5

    • DOI

      10.1109/tmag.2020.3008912

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Multichannel SQUID Magnetoneurograph System for Functional Imaging of Spinal Cords and Peripheral Nerves2021

    • Author(s)
      Adachi Yoshiaki、Kawabata Shigenori、Hashimoto Jun、Okada Yoshinori、Naijo Yoshihisa、Watanabe Taishi、Miyano Yuki、Uehara Gen
    • Journal Title

      IEEE Transactions on Applied Superconductivity

      Volume: 31 Issue: 5 Pages: 1-5

    • DOI

      10.1109/tasc.2021.3056492

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Single Triangular Coil Used to Identify the Position and Orientation of a Subject for Biomagnetic Measurements2019

    • Author(s)
      Adachi Yoshiaki、Oyama Daisuke、Uehara Gen
    • Journal Title

      IEEE Magnetics Letters

      Volume: 10 Pages: 1-5

    • DOI

      10.1109/lmag.2019.2943128

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] チャンネル数、磁場分解能、磁場減衰訂正度の観点から見た生体磁気測定センサアレイの最適化の検討2019

    • Author(s)
      足立善昭, 上原弦
    • Journal Title

      日本生体磁気学会論文誌

      Volume: 32 Pages: 170-171

    • Related Report
      2019 Research-status Report
  • [Journal Article] Calibration of room temperature magnetic sensor array for biomagnetic measurement2019

    • Author(s)
      Yoshiaki Adachi, Daisuke Oyama, Yasushi Terazono, Tatsuya Hayashi, Tomohiko Shibuya, Shigenori Kawabata
    • Journal Title

      IEEE Transactions on Magnetics

      Volume: 印刷中 Issue: 7 Pages: 1-6

    • DOI

      10.1109/tmag.2019.2895355

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] コイルアレイの機械的精度に起因する磁気センサの感度位置校正の不確かさ評価2018

    • Author(s)
      足立善昭, 上原弦
    • Journal Title

      第33回日本生体磁気学会論文集

      Volume: 31 Pages: 170-171

    • Related Report
      2018 Research-status Report
  • [Presentation] Development of the Biomagnetometer System for Magnetospinography / Magnetoneurography (MSG/MNG)2023

    • Author(s)
      Yoshiaki Adachi
    • Organizer
      ACNS(American Clinical Neurophysiology Society) Annual Meeting & Courses
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 神経磁場計測システム2023

    • Author(s)
      足立善昭
    • Organizer
      第70回応用物理学会春季学術講演会シンポジウム
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] SQUIDによる神経磁場計測と応用2023

    • Author(s)
      足立善昭
    • Organizer
      電気学会フォーラム/低温工学シンポジウム
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] Optimization of SQUID sensor arrays for magnetoneurography in terms of pick-up coil diameter2022

    • Author(s)
      Yoshiaki Adachi, Jun Kawai, Hiroshi Deguchi, Yoshihisa Naijo, Yoshinori Okada, Taishi Watanabe, Shigenori Kawabata
    • Organizer
      The 22nd International Conference on Biomagnetism
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A SQUID biomagnetic measurement system for magnetospinography and magnetoneurography and its clinical applications2022

    • Author(s)
      Yoshiaki Adachi, Shigenori Kawabata, Jun Hashimoto, Taishi Watanabe, Kensuke Sekihara, Gen Uehara
    • Organizer
      The 22nd International Conference on Biomagnetism
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A SQUID biomagnetic measurement system for magnetospinography and magnetoneurography2022

    • Author(s)
      Yoshiaki Adachi, Shigenori Kawabata
    • Organizer
      35th International Symposium on Superconductivity
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 複数感度点モデルによるSQUID生体磁気計測のマーカーコイル位置推定精度の改善2022

    • Author(s)
      足立善昭, 高橋陽一郎, 内城禎久, 後藤一磨, 春田康博
    • Organizer
      第37回日本生体磁気学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] SQUIDによる生体磁気検出-MEG, MSG-2022

    • Author(s)
      足立善昭
    • Organizer
      第69回応用物理学会春季学術講演会シンポジウム
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] ベクトル型磁束計は全頭型脳磁計のヘルメット辺縁部の等価電流双極子位置推定精度を改善するか?2021

    • Author(s)
      足立善昭
    • Organizer
      第60回日本生体医工学会大会・第36回日本生体磁気学会
    • Related Report
      2021 Research-status Report
  • [Presentation] 神経磁場計測システムとその臨床応用2021

    • Author(s)
      足立善昭, 川端茂徳
    • Organizer
      令和3年電気学会全国大会シンポジウム
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] SQUID磁気神経イメージング装置の開発2020

    • Author(s)
      足立善昭, 川端茂徳
    • Organizer
      応用物理学会超電導分科会シンポジウム
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] SQUID磁気神経イメージングとその応用2020

    • Author(s)
      足立善昭, 川端茂徳
    • Organizer
      電子情報通信学会ソサイエティ大会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] Multichannel SQUID Magnetoneurogram System for Functional Imaging of Spinal Cords and Peripheral Nerves2020

    • Author(s)
      Yoshiaki Adachi, Shigenori Kawabata, Jun Hashimoto, Yoshinori Okada, Yoshihisa Naijo, Taishi Watanabe, Yuki Miyano, Gen Uehara
    • Organizer
      Applied Superconductivity Conference 2020
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] 神経磁場計測システムの開発2020

    • Author(s)
      足立善昭, 川端茂徳
    • Organizer
      第50回日本臨床神経生理学会シンポジウム
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] チャンネル数、磁場分解能、磁場減衰訂正度の観点から見た生体磁気測定センサアレイの最適化の検討2019

    • Author(s)
      足立善昭, 上原弦
    • Organizer
      第34回日本生体磁気学会
    • Related Report
      2019 Research-status Report
  • [Presentation] Detection of Biomagnetic Signals from Magnetic Sources adjacent to Flux Sensors2019

    • Author(s)
      Yoshiaki Adachi, Shigenori Kawabata
    • Organizer
      The 4th International Workshop on Magnetic Bio-Sensing (IWMBS2019)
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] A method to identify the position and orientation of the subject using only one coil for biomagnetic measurement - an approach using a triangular marker coil2019

    • Author(s)
      Yoshiaki Adachi, Daisuke Oyama, Gen Uehara
    • Organizer
      Magnetic Frontiers 2019
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Calibration of Room-Temperature Magnetic Sensor Arrays for Biomagnetic Measurement2019

    • Author(s)
      Yoshiaki Adachi, Daisuke Oyama, Yasushi Terazono, Tetsuo Hayashi, Tomohiko Shibuya, Shigenori Kawabata
    • Organizer
      2019 Joint MMM-Intermag Conference
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] A method to identify the position and orientation of the subject using only one coil for biomagnetic measurement: An approach using a triangular marker coil2019

    • Author(s)
      Yoshiaki Adachi, Daisuke Oyama, Gen Uehara
    • Organizer
      Magnetic Frontiers 2019
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] ソレノイド型磁気マーカーコイルの位置推定手法2018

    • Author(s)
      小山大介, 足立善昭
    • Organizer
      第42回日本磁気学会
    • Related Report
      2018 Research-status Report
  • [Presentation] A multi-channel SQUID system for biomagnetic measurements2018

    • Author(s)
      Yoshiaki Adachi, Shigenori Kawabata
    • Organizer
      第42回日本磁気学会
    • Related Report
      2018 Research-status Report
  • [Presentation] Visualization of muscle electrical activity after electrical stimulation of the ulnar nerve using superconducting quantum interference device sensors2018

    • Author(s)
      Shuta Ushio, Shigenori Kawabata, Toru Sasaki, Satoshi Sumiya, Taishi Watanabe, Kensuke Sekihara, Yuki Hasegawa, Yoshiaki Adachi, Atsushi Okawa
    • Organizer
      The 31st International Conference on Biomagnetism (Biomag2018)
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Investigation of optimal sensor intervals for a magnetoneurogram system with a vector-type gradiometer array2018

    • Author(s)
      Yoshiaki Adachi, Shigenori Kawabata
    • Organizer
      The 31st International Conference on Biomagnetism (Biomag2018)
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] A SQUID Biomagnetic Measurement System and Its Clinical Applications2018

    • Author(s)
      Yoshiaki Adachi, Shigenori Kawabata
    • Organizer
      The 3rd International Workshop on Magnetic Bio-Sensing (IWMBS2018)
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Book] Emerging MR sensors for biomagnetic measurements: in Flexible High Performance Magnetic Field Sensors: On-Scalp Magnetoencephalography and Other Applications2022

    • Author(s)
      Yoshiaki Adachi, Shigenori Kawabata, Tetsuo Tatsuoka, Yasushi Terazono
    • Total Pages
      14
    • Publisher
      Springer
    • ISBN
      9783031053627
    • Related Report
      2021 Research-status Report
  • [Patent(Industrial Property Rights)] マーカーコイル及び磁気計測装置2019

    • Inventor(s)
      足立善昭
    • Industrial Property Rights Holder
      足立善昭
    • Industrial Property Rights Type
      特許
    • Filing Date
      2019
    • Acquisition Date
      2023
    • Related Report
      2022 Annual Research Report
  • [Patent(Industrial Property Rights)] マーカーコイル及び磁気計測装置2019

    • Inventor(s)
      足立善昭
    • Industrial Property Rights Holder
      金沢工業大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2019-105988
    • Filing Date
      2019
    • Related Report
      2019 Research-status Report

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Published: 2018-04-23   Modified: 2024-01-30  

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