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Non-contact, high-speed, quantitative hemodynamic imaging using new spatially resolved spectroscopy

Research Project

Project/Area Number 18K12053
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 90110:Biomedical engineering-related
Research InstitutionShizuoka University

Principal Investigator

Niwayama Masatsugu  静岡大学, 電子工学研究所, 准教授 (40334958)

Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2021: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords近赤外分光法 / ヘモグロビン / オキシメトリ
Outline of Final Research Achievements

In this study, we aimed to develop a technique for grasping blood dynamics easily and quantitatively in a non-contact manner using spatially-resolved near-infrared spectroscopy with a new sensor arrangement, and explored conditions and methods that can be measured accurately. Based on the computer simulation of light propagation, the change in measurement depth and the change in sensitivity due to the combination of distances between transmitters and receivers were quantitatively clarified. From these results, we have established the basis of a new measurement method that can make the measurement depth variable. In addition, the developed oximeter could be shown to be useful for vascular surgery.

Academic Significance and Societal Importance of the Research Achievements

測定できる深さを変えることができる多点計測法に関する成果は、詳細な理論解析に基づく知見・考察から導かれたものであり、解析結果や新たな演算アルゴリズムは学術的にも重要である。また、本手法を用いて試作した多点血液動態モニタを血管外科手術での患部監視に応用し、血管内にステントを留置する際の効果をリアルタイムかつ定量的に把握するうえで有用であることが示された。本手法による高い利便性と定量性を併せ持つ血液動態計測法は、多様な健康管理ツールや新医療機器開発にも有用と考えられる。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (31 results)

All 2022 2021 2020 2019 2018

All Journal Article (10 results) (of which Peer Reviewed: 10 results,  Open Access: 6 results) Presentation (19 results) (of which Int'l Joint Research: 15 results,  Invited: 1 results) Book (1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Real-time Assessment of Tissue Oxygenation in Each Angiosome During Endovascular Therapy for Chronic Limb-threatening Ischemia Patients Using a Novel Oximeter TOE-202022

    • Author(s)
      N. Unno, K. Inuzuka, M. Sano, M. Niwayama, E. Naruse, H. Takeuchi
    • Journal Title

      Journal of Vascular Surgery Cases and Innovative Techniques

      Volume: 21 Issue: 2 Pages: 158-163

    • DOI

      10.1016/j.jvscit.2021.07.001

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Tissue Oximeter with Selectable Measurement Depth Using Spatially Resolved Near-Infrared Spectroscopy2021

    • Author(s)
      M. Niwayama, N. Unno
    • Journal Title

      Sensors

      Volume: 21 Issue: 16 Pages: 55731-11

    • DOI

      10.3390/s21165573

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Skeletal Muscle Deoxygenation and Its Relationship to Aerobic Capacity During Early and Late Stages of Aging.2021

    • Author(s)
      Takagi S, Kime R, Murase N, Niwayama M, Sakamoto S, Katsumura T.
    • Journal Title

      Advances in Experimental Medicine & Biology

      Volume: 1269 Pages: 77-82

    • DOI

      10.1007/978-3-030-48238-1_12

    • ISBN
      9783030482367, 9783030482381
    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Term Newborns with relatively low Tissue Oxygen Saturation Levels soon after Birth are predisposed to Neonatal Respiratory Disorders in Low-risk, Elective Cesarean Sections2021

    • Author(s)
      Kawai K, Uchida T, Mukai M, Matsumoto M, Itoh T, Oda T, Horikoshi Y, Suzuki K, Kohmura-Kobayashi Y, Furuta-Isomura N, Yaguchi C, Niwayama M, Itoh H, Kanayama N
    • Journal Title

      International Journal of Medical Sciences

      Volume: 18 Issue: 11 Pages: 2262-2268

    • DOI

      10.7150/ijms.53945

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Differences in muscle O2 dynamics during treadmill exercise between aerobic capacity-matched overweight and normal-weight adults2020

    • Author(s)
      Takagi S, Kime R, Midorikawa T, Niwayama M, Sakamoto S, Katsumura T
    • Journal Title

      Advances in Experimental Medicine and Biology

      Volume: 1232 Pages: 223-229

    • DOI

      10.1007/978-3-030-34461-0_28

    • ISBN
      9783030344597, 9783030344610
    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Utility of a Finger-Mounted Tissue Oximeter with Near-Infrared Spectroscopy to Evaluate Limb Ischemia in Patients with Peripheral Arterial Disease2019

    • Author(s)
      Yata T, Sano M, Kayama T, Naruse E, Yamamoto N, Inuzuka K, Saito T, Katahashi K, Yamanaka Y, Uchida T, Niwayama M, Kanayama N, Takeuchi H, Unno N
    • Journal Title

      Annals of Vascular Diseases

      Volume: 12 Issue: 1 Pages: 36-43

    • DOI

      10.3400/avd.oa.18-00117

    • NAID

      130007618832

    • ISSN
      1881-641X, 1881-6428
    • Year and Date
      2019-03-25
    • Related Report
      2019 Research-status Report 2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Implantable Multi-modality Probe for Subdural Simultaneous Measurement of Electrophysiology, Hemodynamics, and Temperature Distribution2019

    • Author(s)
      T. Yamakawa, T. Inoue, M. Niwayama, F. Oka, H. Imoto, S. Nomura, M. Suzuki
    • Journal Title

      IEEE Transactions on Biomedical Engineering

      Volume: 2 Issue: 11 Pages: 1-8

    • DOI

      10.1109/tbme.2019.2902189

    • Related Report
      2019 Research-status Report 2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 多様な生体組織を対象とした近赤外分光オキシメトリ2019

    • Author(s)
      庭山 雅嗣
    • Journal Title

      レーザー研究

      Volume: 47 Pages: 594-597

    • NAID

      130008074891

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Reevaluation of intrapartum fetal monitoring using fetal oximetry: A review.2018

    • Author(s)
      Uchida T, Kanayama N, Kawai K, Mukai M, Suzuki K, Itoh H, Niwayama M
    • Journal Title

      J Obstet Gynaecol Res

      Volume: 44 Issue: 12 Pages: 2127-2134

    • DOI

      10.1111/jog.13761

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of Aerobic Cycling Training on O2 Dynamics in Several Leg Muscles in Early Post-Myocardial Infarction2018

    • Author(s)
      S. Takagi, R. Kime, N. Murase,M. Niwayama, T. Osada, and T. Katsumura
    • Journal Title

      Advances in Experimental Medicine and Biology

      Volume: 1072 Pages: 91-96

    • DOI

      10.1007/978-3-319-91287-5_15

    • ISBN
      9783319912851, 9783319912875
    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Presentation] 近赤外光による血液動態計測システム2021

    • Author(s)
      庭山 雅嗣
    • Organizer
      Medtec Japan 2021
    • Related Report
      2021 Annual Research Report
  • [Presentation] 内視鏡用組織酸素センサーの開発~ NIRS内視鏡2020

    • Author(s)
      庭山雅嗣
    • Organizer
      エコシステム形成プログラム技術発表会
    • Related Report
      2020 Research-status Report
  • [Presentation] A time-resolved near-infrared spectroscopy based on CMOS image sensor2020

    • Author(s)
      Lioe De Xing, Hakamata M, Yasutomi K, Kagawa K, Niwayama M, Fukushi Y, Yamamoto S, Kawahito S
    • Organizer
      SPIE Photonics West
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] 空間分解計測法を用いた多種組織用オキシメータの開発2020

    • Author(s)
      庭山雅嗣
    • Organizer
      Optics & Photonics Japan 2020
    • Related Report
      2020 Research-status Report
  • [Presentation] 多様な生体組織を対象とした近赤外分光血液動態計測2020

    • Author(s)
      庭山雅嗣
    • Organizer
      生体医歯工学共同研究拠点医工連携セミナー
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] Measurement Sensitivity enhancement of surface tissue using planar light source and spatially-resolved near-infrared spectroscopy2019

    • Author(s)
      K. Tsubota, M. Niwayama
    • Organizer
      The 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society(EMBC 2019)
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Determination of facial optical properties based on ToF, spatially-resolved and time-resolved measurement2019

    • Author(s)
      J. Nagakura, M. Niwayama
    • Organizer
      The 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society(EMBC 2019)
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Measurement sensitivity and sensor arrangement for liver tissue oximeter2019

    • Author(s)
      T. Kanzawa, M. Niwayama
    • Organizer
      The 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society(EMBC 2019)
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Development of a new intrapartum fetal monitoring technique using a finger-mounted fetal tissue oximetry2019

    • Author(s)
      K. Kawai, T. Uchida, H. Itoh, M. Niwayama, N. Kanayama
    • Organizer
      The 4th International Symposium on Biomedical Engineering
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Simultaneous Measurement of Electrophysiology, Hemodynamics, and Temperature Distribution on Cortex using Subdurally Implantable Multimodality Probe2019

    • Author(s)
      T. Yamakawa, T. Inoue, M. Niwayama, F. Oka, H. Imoto, S. Nomura, M. Suzuki, T. Aoki
    • Organizer
      The 4th International Symposium on Biomedical Engineering
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] An oxygen environment in the subcutaneous tissue could be a key for obtaining the soft and elastic skin2019

    • Author(s)
      K. Mizukoshi, Y. Hamanaka, M. Kurosumi, M. Niwayama
    • Organizer
      The 4th International Symposium on Biomedical Engineering
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Intestinal tissue oximetry using spatially resolved near-infrared spectroscopy and pathlength measurement2019

    • Author(s)
      K. Suzuki, M. Niwayama
    • Organizer
      The 4th International Symposium on Biomedical Engineering
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Measurement Sensitivity Enhancement of Surface Tissue Using Spatially-resolved NIRS2019

    • Author(s)
      K. Tsubota, M. Niwayama
    • Organizer
      The 4th International Symposium on Biomedical Engineering
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Facial optical property measurement using spatially-resolved and time-resolved measurement2019

    • Author(s)
      J. Nagakura, M. Niwayama
    • Organizer
      The 4th International Symposium on Biomedical Engineering
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Measurement sensitivity analysis for liver tissue oximeter2019

    • Author(s)
      T. Kanzawa, M. Niwayama
    • Organizer
      The 4th International Symposium on Biomedical Engineering
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Characteristic analysis of intestinal tissue measurement using spatially resolved near-infrared spectroscopy2018

    • Author(s)
      K. Suzuki and M. Niwayama
    • Organizer
      The 40th Ann. Int. Conf. the IEEE Eng. Med. Biol. Soc
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Sensitivity analysis and probe development for pig brain measurement using NIRS2018

    • Author(s)
      K. Watanabe and M. Niwayama
    • Organizer
      The 40th Ann. Int. Conf. the IEEE Eng. Med. Biol. Soc
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Oxygenation measurement for intestinal tissue and contents using spatially resolved near-infrared spectroscopy2018

    • Author(s)
      K. Suzuki, M. Niwayama
    • Organizer
      The 20th Takayanagi Kenjiro Memorial Symposium
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Development of deep muscle oximeter for deformed tissues by pinching using near-infrared spectroscopy2018

    • Author(s)
      Y. Matsuki, M. Niwayama
    • Organizer
      The 3rd Interational Symposium on Biomedical Engineering, 8 Nov. 2018, Hiroshima University
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Book] 生体ひかりイメージングの基礎と応用2021

    • Author(s)
      庭山 雅嗣
    • Total Pages
      30
    • Publisher
      (株)エヌ・ティー・エス
    • ISBN
      9784860437299
    • Related Report
      2021 Annual Research Report
  • [Patent(Industrial Property Rights)] 測定感度算出方法、測定感度算出装置、測定感度算出プログラム、及び光学的測定装置2020

    • Inventor(s)
      庭山雅嗣
    • Industrial Property Rights Holder
      庭山雅嗣
    • Industrial Property Rights Type
      特許
    • Filing Date
      2020
    • Related Report
      2020 Research-status Report

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Published: 2018-04-23   Modified: 2023-01-30  

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