| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
In this study, we developed a sensor which can detect distribution of refractive index (RI) and impedance changes on a sensor chip without any labeling in a real time manner. Using the impedance sensor, we demonstrated that tissue factor (TF)-expressed on vascular endothelial cells (HUVECs) activate extrinsic coagulation cascade and induce gap formation of vascular endothelial cells in the presence of plasma. Moreover, we clarified TF expression levels are increased in patients with chronic spontaneous urticarial (CSU), and TF expressed on monocytes also induce activation of extrinsic coagulation cascade and then cap formation of vascular endothelial cells in the presence of human plasma by means of impedance sensor.
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