Development of potential new incubator using artificial oxygen carriers

• Project/Area Number: 18K12072
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 90110:Biomedical engineering-related
• Research Institution: Akita University (2022); National Center of Neurology and Psychiatry (2018)
• Principal Investigator: Ohta Hidenobu 秋田大学, 医学系研究科, 教授 (80422103)
• Co-Investigator(Kenkyū-buntansha): 磯山 隆 東京大学, 大学院医学系研究科(医学部), 講師 (20302789) ; 酒井 宏水 奈良県立医科大学, 医学部, 教授 (70318830)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2022)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 人工血液カクテル / 次世代保育器 / 早産児 / 外部循環回路 / 血液呼吸 / 血液換気ユニット

Outline of Final Research Achievements

This research aims to develop a new incubator using artificial oxygen carriers to treat preterm infants. Using a rat model, we attempted to develop such incubator and also examined the safety of the incubator for fetal development.

Academic Significance and Societal Importance of the Research Achievements

この新しいタイプの次世代保育器を開発できれば、母体同様の子宮環境を人工的に提供することが可能となり、早産児の発達過程で高率に発生する肺機能低下および脳機能障害（ADHD・自閉症）を完全に予防し、満期産児と同じ発達「後遺症なき生存」が達成される。