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Modification of antigenicity for cancer cells by foreign peptide decoration by using hyaluronic acid

Research Project

Project/Area Number 18K12082
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 90120:Biomaterials-related
Research InstitutionThe University of Kitakyushu

Principal Investigator

Mochizuki Shinichi  北九州市立大学, 国際環境工学部, 准教授 (10520702)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2019: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Keywords薬物送達システム / がんワクチン / 多糖 / 抗原提示 / 抗原 / 免疫療法 / 糖鎖 / 抗原ペプチド
Outline of Final Research Achievements

The prepared conjugates consisting of hyaluronic acid (HA) and ovalbumin (OVA) are incorporated into cancer cells through HA receptor CD44. When cancer cells treated with HA-OVA conjugates and splenocytes immunized with OVA and adjuvants, strong immune responses were observed. These results indicate OVA fragments are presented on the cancer cellular surface, and we succeeded in modification of cancer antigenicity.

Academic Significance and Societal Importance of the Research Achievements

チェックポイント阻害剤等による免疫抑制が解除されたのち、実際に腫瘍を縮退させるのは患者がもともと体内に持っている免疫力、つまり細胞傷害性T細胞(CTL)の力である。CTLが十分に能力を発揮させるための技術開発は、がん免疫療法を次のステージに発展させる鍵と考えられる。その中で、本提案の抗原性改変技術はがんワクチンに対する新たな戦略の一つになり得ると確信している。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (22 results)

All 2021 2020 2019 2018 Other

All Journal Article (8 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 8 results) Presentation (10 results) (of which Int'l Joint Research: 3 results,  Invited: 1 results) Remarks (2 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Binding assay of human Dectin-1 variants to DNA/β-glucan complex for active-targeting delivery of antisense DNA2021

    • Author(s)
      Fujiwara Nobuaki、Izumi Hiroto、Kira Ryoma、Morimoto Yasuo、Mochizuki Shinichi、Sakurai Kazuo
    • Journal Title

      Carbohydrate Research

      Volume: 500 Pages: 108219-108219

    • DOI

      10.1016/j.carres.2020.108219

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Extending the Half-Life of a Protein in Vivo by Enzymatic Labeling with Amphiphilic Lipopeptides2021

    • Author(s)
      Mari Takahara , Shinichi Mochizuki , Rie Wakabayashi , Kosuke Minamihata , Masahiro Goto , Kazuo Sakurai , Noriho Kamiya
    • Journal Title

      Bioconjugate Chemistry

      Volume: accepted Issue: 4 Pages: 655-660

    • DOI

      10.1021/acs.bioconjchem.1c00027

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immune Responses and Antitumor Effect through Delivering to Antigen Presenting Cells by Optimized Conjugates Consisting of CpG-DNA and Antigenic Peptide2020

    • Author(s)
      Irie Hitomi、Morita Koji、Koizumi Makoto、Mochizuki Shinichi
    • Journal Title

      Bioconjugate Chemistry

      Volume: 31 Issue: 11 Pages: 2585-2595

    • DOI

      10.1021/acs.bioconjchem.0c00523

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Induction of potent cell growth inhibition by schizophyllan/K-ras antisense complex in combination with gemcitabine2020

    • Author(s)
      Sasaki Shogo、Izumi Hiroto、Morimoto Yasuo、Sakurai Kazuo、Mochizuki Shinichi
    • Journal Title

      Bioorganic & Medicinal Chemistry

      Volume: 28 Issue: 18 Pages: 115668-115668

    • DOI

      10.1016/j.bmc.2020.115668

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oligo-DNA Stoichiometrically Binds β-1,3-Glucan with the Best Fit Length2020

    • Author(s)
      Sumiya Kazuki、Matsunaga Takuya、Tanaka Motoko、Mochizuki Shinichi、Sakurai Kazuo
    • Journal Title

      Biomacromolecules

      Volume: 21 Issue: 12 Pages: 4823-4834

    • DOI

      10.1021/acs.biomac.0c01038

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Topical Therapy with Antisense Tumor Necrosis Factor Alpha Using Novel β-Glucan-Based Drug Delivery System Ameliorates Intestinal Inflammation2020

    • Author(s)
      Sakisaka Hideto、Takedatsu Hidetoshi、Mitsuyama Keiichi、Mochizuki Shinichi、Sakurai Kazuo、Sakisaka Shotaro、Hirai Fumihito
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 21 Issue: 2 Pages: 683-683

    • DOI

      10.3390/ijms21020683

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] An Agarose-Curdlan Nanogel That Carries Etanercept to Target and Neutralizes TNF-a Produced by Dectin-1-Expressing Immune Cells2019

    • Author(s)
      Dung Hyang Nguyen、Ngoc Bao Chau Nguyen、Linh T.P. Nguyen、Ly T. Do、Tung T. Nguyen、Nam H. Nguyen、Sakurai Kazuo、Mochizuki Shinichi、Kihara Takanori、Thang Dinh Nguyen、Anh Thi Van Nguyen、Houng T.T. Pham
    • Journal Title

      Journal of Electronic Materials

      Volume: 48 Pages: 6570-6582

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Complex consisting of antisense DNA and β-glucan promotes internalization into cell through Dectin-1 and hybridizes with target mRNA in cytosol2019

    • Author(s)
      Nobuaki Fujiwara, Hiroto Izumi, Yasuo Morimoto, Kazuo Sakurai, Shinichi Mochizuki
    • Journal Title

      Cancer Gene Ther

      Volume: 26 Issue: 1-2 Pages: 32-40

    • DOI

      10.1038/s41417-018-0033-2

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Presentation] 生体内コミュニケーションを利用したDDS とそのがんワクチンへの応用2021

    • Author(s)
      望月慎一
    • Organizer
      高分子学会九州支部大学間連携フォーラム
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 抗原提示誘導を目指した核酸、抗原送達システムの構築2020

    • Author(s)
      望月慎一、緒方聡一、辻玲香
    • Organizer
      第69回高分子討論会
    • Related Report
      2020 Annual Research Report
  • [Presentation] アジュバント核酸-抗原ペプチドコンジュゲート体による細胞性免疫の誘導2020

    • Author(s)
      入江瞳、望月慎一
    • Organizer
      第36回日本DDS学会学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Enhancement of cancer vaccine by modification of antigenicity for cancer cells2019

    • Author(s)
      Shinichi Mochizuki
    • Organizer
      257th ACS National Meeting & Expo
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] ヒアルロン酸を利用した抗原送達によるがん細胞の抗原性の改変2019

    • Author(s)
      望月慎一
    • Organizer
      第35回日本DDS学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 抗原修飾ヒアルロン酸を用いたがん細胞の抗原性改変2019

    • Author(s)
      望月慎一
    • Organizer
      第68回高分子討論会
    • Related Report
      2019 Research-status Report
  • [Presentation] Enhancement of cancer vaccine by modification of antigenicity for cancer cells2019

    • Author(s)
      Shinichi Mochizuki
    • Organizer
      15th Annual Meeting of the Oligonucleotide Therapeutics Society
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] CTL活性の向上を目指した免疫細胞・がん細胞への抗原デリバリーシステムの開発2018

    • Author(s)
      望月慎一
    • Organizer
      第47回医用高分子シンポジウム
    • Related Report
      2018 Research-status Report
  • [Presentation] Induction of potent cytotoxic T-lymphocyte activity using two types of polysaccharides2018

    • Author(s)
      Shinichi Mochizuki
    • Organizer
      256th ACS National Meeting & Exposition
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] シゾフィランを用いた核酸デリバリーの細胞内動態2018

    • Author(s)
      望月慎一
    • Organizer
      第67回高分子学会年次
    • Related Report
      2018 Research-status Report
  • [Remarks] 北九州市立大学 櫻井・望月研究室HP

    • URL

      http://www.sakurai-lab.jp/index.php/

    • Related Report
      2020 Annual Research Report 2019 Research-status Report
  • [Remarks] 北九州市立大学 教員紹介(望月)

    • URL

      https://www.kitakyu-u.ac.jp/env/faculty/d-life/introduction/shinichi-mochizuki.html

    • Related Report
      2020 Annual Research Report 2019 Research-status Report
  • [Patent(Industrial Property Rights)] ポリヌクレオチド-ペプチドコンジュゲートを含む免疫誘導剤およびそれを含む医薬組成物2020

    • Inventor(s)
      望月慎一、小泉誠、森田浩二
    • Industrial Property Rights Holder
      望月慎一、小泉誠、森田浩二
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2020-057249
    • Filing Date
      2020
    • Related Report
      2019 Research-status Report
  • [Patent(Industrial Property Rights)] 抗原ペプチド-アジュバントヌクレオチドコンジュゲート体を含む免疫誘導剤及びそれを含む医薬組成物2018

    • Inventor(s)
      望月慎一、小泉誠、森田浩二
    • Industrial Property Rights Holder
      望月慎一、小泉誠、森田浩二
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2018-186093
    • Filing Date
      2018
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2022-01-27  

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