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Development of poorly absorbable drug delivery system in vivo by sonodynamic action

Research Project

Project/Area Number 18K12086
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 90120:Biomaterials-related
Research InstitutionYokohama College of Pharmacy

Principal Investigator

Iwase Yumiko  横浜薬科大学, 薬学部, 准教授 (00521882)

Co-Investigator(Kenkyū-buntansha) 弓田 長彦  横浜薬科大学, 薬学部, 教授 (40191481)
西 弘二  崇城大学, 薬学部, 准教授 (00398249)
梅村 晋一郎  東北大学, 医工学研究科, 学術研究員 (20402787)
Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords薬物送達 / 音響化学的作用 / 超音波 / 難吸収性薬物 / 音響化学作用
Outline of Final Research Achievements

Ultrasound irradiation with a frequency of 3 MHz is less likely to cause cavitation that repeatedly contracts and expands due to the accumulation of energy in bubbles in the solution and produces a jet flow accompanied by a temporary high temperature state. That conditions allowed us to minimize cells and tissues damage. It was suggested that ultrasonic irradiation under this condition may increase drug delivery through the intercellular pathway. Ultrasound irradiation increased the absorption of drugs with low absorption ratio even with a small molecular weight. Furthermore, it was confirmed that the absorption of drugs with a large molecular weight, whose absorption pathway is limited, was increased. From the above, it was suggested that ultrasonic irradiation with a frequency of 3 MHz may safely increase drug delivery to tissues through the gastrointestinal membrane permeation.

Academic Significance and Societal Importance of the Research Achievements

医薬品の投与経路として経口投与は利便性が高く安全性も高い。また、用量や剤型を比較的自由に選択できる利点があることから依然として信望されている。しかし、経口投与される医薬品は消化管から吸収されなければ全身への効果が期待できない。そのため、消化管から効率よく吸収されることが必須となる。これまでは、医薬品に対し個々の対応がとられるため、医薬品開発費や時間がかかっていた。本研究では生体側へアプローチすることで難吸収性薬物の吸収を改善する手法の開発を試みた。この手法の確立は薬物の特性にとらわれず薬効を重視した医薬品開発を実現できるものと考える。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (6 results)

All 2019 2018

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (4 results)

  • [Journal Article] Apoptosis Induced by Ultraviolet A Exposure in the Presence of Enoxacin in HL-60 Cells.2019

    • Author(s)
      Shinada H, Watanabe T, Okudaira K, Iwase Y, Nishi K, Yumita N.
    • Journal Title

      Anticancer Res.

      Volume: 39 Issue: 2 Pages: 687-693

    • DOI

      10.21873/anticanres.13164

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Glutamine deprivation enhances acetyl-CoA carboxylase inhibitor-induced death of human pancreatic cancer cells.2018

    • Author(s)
      Nishi K, Suzuki M, Yamamoto N, Matsumoto A, Iwase Y, Yamasaki K, Otagiri M, Yumita N
    • Journal Title

      Anticancer Res

      Volume: 38 Issue: 12 Pages: 6683-6689

    • DOI

      10.21873/anticanres.13036

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Involvement of singlet oxygen in apoptosis induced by UVAexposure in the presence of enoxacin2019

    • Author(s)
      Yumiko Iwase, Koji Nishi, Nagahiko Yumita
    • Organizer
      第78回日本癌学会総会
    • Related Report
      2019 Research-status Report
  • [Presentation] 膵がん治療における超音波照射によるドラッグデリバリーの研究2019

    • Author(s)
      加藤愛美、西弘二、岩瀬由未子、梅村晋一郎、弓田長彦
    • Organizer
      日本薬学会第139年会
    • Related Report
      2018 Research-status Report
  • [Presentation] UVAおよびエノキサシン併用による一重項酸素産生のESRによる研究2019

    • Author(s)
      品田春佳、岩瀬由未子、弓田長彦
    • Organizer
      日本薬学会第139年会
    • Related Report
      2018 Research-status Report
  • [Presentation] Involvement of Reactive Oxygen Species in Apoptosis Induced byCombination of UVA and Enoxacin2018

    • Author(s)
      Yumiko Iwase, Koji Nishi, Nagahiko Yumita
    • Organizer
      The 77th Annual Meeting of the Japanese Cancer Association
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2023-01-30  

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