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Development for Super-low-invasive drag Surgery system using photonic DNA nano-machine

Research Project

Project/Area Number 18K12105
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 90130:Medical systems-related
Research InstitutionHiroshima Institute of Technology

Principal Investigator

Yamada Kenji  広島工業大学, 工学部, 教授 (70364114)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
KeywordsDNA / リポソーム / 光ピンセット / 低侵襲手術 / レーザ操作 / ナノ / フォトニクス / 低侵襲治療システム / 内視鏡
Outline of Final Research Achievements

We have developed a prototype of an ultra-minimally invasive drug surgery system using a photonic DNA nanomachine, and established a basic technology to evaluate the characteristics and performance of the system.
We designed and prototyped liposomes containing photonic DNA nanomachines, and established a liposome production technology containing photonic DNA nanomachines.
Using optical tweezers, we confirmed the operation of liposomes containing DNA nanomachines. We have been able to establish a technology that can directly irradiate liposomes with laser light, and by irradiating lasers with different wavelengths in the future, we will selectively destroy liposomes containing DNA nanomachines and apply DNA nanomachines directly to the affected area of the surgical site. Established the technology that can be done.

Academic Significance and Societal Importance of the Research Achievements

本研究では,生物学的な要素であるDNAを利用することにより,がん細胞だけでなく,微小病変の治療をより多様性をもって治療できる可能性があるところに,大きな意義を持つと考える.本研究により得られたDNAナノマシーンを含有したリポソームを患部に塗布し、内視鏡のようなシステムを通して、異なる波長を制御することにより現在行われている低侵襲手術をより正確に精密に行うことができる基礎基盤技術の確立ができた。今後、生物学的要素を利用した研究が推進され、より身体に優しくかつ精密な低侵襲手術の可能性を示せたことは、さらに加速する高齢化における治療に大いに意義のあることであり、医療費削減に大きく貢献するものである。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (4 results)

All 2020 2019

All Presentation (4 results) (of which Invited: 1 results)

  • [Presentation] フォトニック DNA ナノマシンによる低侵襲ドラックサージェリシステムの構築2020

    • Author(s)
      沖川一平、山田憲嗣
    • Organizer
      第8回 看護理工学会学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Development for a screening system based on nano structure photonics crystal in homecare2019

    • Author(s)
      kana Kodama, Kenji Yamada,
    • Organizer
      SPIE Optical Engineering + Applications
    • Related Report
      2019 Research-status Report
  • [Presentation] Photoacoustic imaging system using LED2019

    • Author(s)
      大藤慎也,山田憲嗣
    • Organizer
      令和元年度(第70回)電気・情報関連学会中国支部連合大会
    • Related Report
      2019 Research-status Report
  • [Presentation] Nursing Engineering and Japan Biodesign Program2019

    • Author(s)
      Kenji Yamada
    • Organizer
      The 12th Biomedical Engineering International Conference (BMEiCON2019)
    • Related Report
      2019 Research-status Report
    • Invited

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Published: 2018-04-23   Modified: 2022-01-27  

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