| Project/Area Number |
18K12133
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 90140:Medical technology assessment-related
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| Research Institution | Kagoshima University |
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Principal Investigator |
Hayashi Sadao 鹿児島大学, 医歯学域鹿児島大学病院, 助教 (10549918)
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| Co-Investigator(Kenkyū-buntansha) |
吉浦 敬 鹿児島大学, 医歯学域医学系, 教授 (40322747)
福倉 良彦 川崎医科大学, 医学部, 教授 (50315412)
泉 俊彦 鹿児島大学, 医歯学総合研究科, 客員研究員 (70768762)
栫 博則 鹿児島大学, 医歯学域医学系, 助教 (50423728)
海江田 英泰 鹿児島大学, 鹿児島大学病院, 医員 (40894241)
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| Project Period (FY) |
2018-04-01 – 2023-03-31
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| Project Status |
Completed (Fiscal Year 2022)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 運動器カテーテル塞栓 / MRI / 塞栓術 |
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| Outline of Final Research Achievements |
Neovessels and accompanying nerves are sources of inflammation and pain in chronic osteoarthritis. It was reported that pH in the synovial fluid is a useful marker of local inflammatory activity. Our purpose was to develop an MRI-based pH measurement method for outcome prediction in patients treated with transcatheter arterial embolization. We conducted a phantom experiment to test the feasibility of chemical exchange saturation transfer MRI-based pH measurement. Six samples containing 2 different concentrations (5% and 10%) of egg-white albumin at 3 different pH (6.4, 7.4, and 8.0) were scanned. The amine/amide concentration-independent detection (AACID) scale was calculated for each sample. For both concentrations, there was a significant negative correlation between AACID scale and pH (r = -0.901 and -0.915). Moreover, the AACID scale did not significantly differ between the two concentrations, indicating the feasibility of concentration-independent pH measurement using AACID.
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| Academic Significance and Societal Importance of the Research Achievements |
近年、関節炎患者の関節液はアシドーシス（低pH）・低酸素環境であることが知られている。
AACIDと呼ばれる精度の高く実用的なpHイメージングを用いることで関節液のpHを正確に測定でき、血管塞栓術の治療効果予測に役立てることができるかを評価した。タンパク濃度およびpHが高くなるほど、AACIDは低値を示し、pH6,4から8.0においてはpHとAACIDは負の相関を認め、タンパク濃度の違いでAACIDに有意な差はみられず、AACIDによるpHイメージングにおいてはタンパク濃度の違いによる影響がAPTイメージングにおける不安定性を抑えており、生体内のpHを評価できる可能性が示唆された。
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