History of Traditional Japanese Pediatrics and Their Applications to Modern Pediatrics

• Project/Area Number: 18K12273
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 01080:Sociology of science, history of science and technology-related
• Research Institution: Nagoya University
• Principal Investigator: Kawashima Nozomu 名古屋大学, 医学部附属病院, 助教 (30772264)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 小児伝統医学 / 漢方医学 / 小児科学 / 医史学 / 系統樹 / 古典籍 / 光学文字認識 / 電子テキスト翻刻 / 伝統小児科学 / 構造化データベース / 光学認識装置 / 電子テキスト

Outline of Final Research Achievements

Traditional Kampo pediatrics has been incorporated into modern pediatrics in Japan. However, the historical context leading to this integrative pediatrics has not been clarified. This study aimed to understand Japanese pediatrics through establishing an electrical bibliography on pediatric classics in Japan.
First, texts of studies on Japanese pediatrics were comprehensively digitized. Then, a bibliographic list of Kampo pediatrics was established. A new seamless system to generate high-grade electronic texts from images of classics was also established, and the data were edited by professionals in medicine and literature, which produced 11 classics containing precise text data. A database on Japanese classical pediatrics is currently under construction.
Through this study, kambakutaisoto was prescribed for pediatric night crying and parasomnia, and it was shown to be safe and effective in a clinical study among currently hospitalized children.

Academic Significance and Societal Importance of the Research Achievements

これまでの小児科史を含む医史学的研究は、医書の解題と翻刻を行い定性的な書誌学情報を得て比較検討する方法が主流であるため歴代医書の情報を並列処理することは困難であった。小児科・漢方専門医でもある研究代表者は漢方医書の病名と方剤が医書の種類や時代、流派に関係なく記載がみられることに着目して、古典の電子テキスト化とデータベース構築が定量的な小児科史の理解に繋がると仮説を立てた。医学古典に特化して書影から正確な電子テキストを作出するシステムを初めて構築して11文献を電子テキスト化したことで医史学の深化に貢献した。そのデータから新たな治療法シーズが得られたことでも意義深いと考えられる。

Research Products

• [Journal Article] Kambakutaisoto Treatment for Children With Night Crying and Arousal Parasomnias Developed During Prolonged Hospitalization for Hematological and Oncological Diseases (2021)
  • Author(s): Kawashima Nozomu
  • Journal Title: Journal of Child Neurology Volume: - Issue: 7 Pages: 568-574
  • DOI: 10.1177/0883073820984062
  • NAID: 120007127378
  • Peer Reviewed
• [Journal Article] 明治期皇子女と漢方医―なぜ漢方医が皇子女の主治医となり最終的に罷免に至ったか？― (2021)
  • Author(s): 川島希
  • Journal Title: 日本医史学雑誌 Volume: 67 Pages: 32-47
  • NAID: 40022534823
  • Peer Reviewed / Open Access
• [Journal Article] Detection of subclonal SETBP1 and JAK3 mutations in juvenile myelomonocytic leukemia using droplet digital PCR (2020)
  • Author(s): Wakamatsu Manabu、Okuno Yusuke、Murakami Norihiro、Miwata Shunsuke、Kitazawa Hironobu、Narita Kotaro、Kataoka Shinsuke、Ichikawa Daisuke、Hamada Motoharu、Taniguchi Rieko、Suzuki Kyogo、Kawashima Nozomu、Nishikawa Eri、Narita Atsushi、Nishio Nobuhiro、Kojima Seiji、Muramatsu Hideki、Takahashi Yoshiyuki
  • Journal Title: Leukemia Volume: 35 Issue: 1 Pages: 259-263
  • DOI: 10.1038/s41375-020-0817-x
  • Peer Reviewed
• [Journal Article] Comparison of the formulas from the current form of traditional Japanese pediatrics and those described in Yoyokasoku (in‐house methods of pediatrics): A representative pediatric classic (2020)
  • Author(s): Kawashima Nozomu
  • Journal Title: Traditional & Kampo Medicine Volume: 8 Issue: 1 Pages: 100-105
  • DOI: 10.1002/tkm2.1262
  • NAID: 120006900385
  • Peer Reviewed
• [Journal Article] Risk factors for secondary poor graft function after bone marrow transplantation in children with acquired aplastic anemia (2020)
  • Author(s): Hama A, Muramatsu H, Narita A, Nishikawa E, Kawashima N, Nishio N, Kojima S, Takahashi Y.
  • Journal Title: Pediatr Transplant. Volume: 24 Issue: 7
  • DOI: 10.1111/petr.13828
  • Peer Reviewed
• [Journal Article] 『幼幼家則』にみる疾医が記載する小児の灸・外科治療 (2020)
  • Author(s): 川島希
  • Journal Title: 日本小児東洋医学会誌 Volume: 31 Pages: 35-44
  • NAID: 120006937483
  • Peer Reviewed / Open Access
• [Journal Article] 【原発性免疫不全症候群-最新の疾患分類と新規疾患を中心に-】骨髄不全 Fanconi anemia type A～W (2020)
  • Author(s): 川島希
  • Journal Title: 日本臨床 Volume: 78増刊7 Pages: 485-488
  • Open Access
• [Journal Article] Allogeneic stem cell transplantation with reduced intensity conditioning for patients with adrenoleukodystrophy (2019)
  • Author(s): Kato Koji、Maemura Ryo、Wakamatsu Manabu、Yamamori Ayako、Hamada Motoharu、Kataoka Shinsuke、Narita Atsushi、Miwata Shunsuke、Sekiya Yuko、Kawashima Nozomu、Shimozawa Nobuyuki、Yoshida Nao、et al
  • Journal Title: Molecular Genetics and Metabolism Reports Volume: 18 Pages: 1-6
  • DOI: 10.1016/j.ymgmr.2018.11.001
  • Peer Reviewed / Open Access
• [Journal Article] Prophylaxis and treatment with mycophenolate mofetil in children with graft-versus-host disease undergoing allogeneic hematopoietic stem cell transplantation: a nationwide survey in Japan (2019)
  • Author(s): Kawashima Nozomu、Iida Minako、Suzuki Ritsuro、Fukuda Takahiro、Atsuta Yoshiko、Hashii Yoshiko、Inoue Masami、Kobayashi Masao、Yabe Hiromasa、Okada Keiko、Adachi Souichi、Yuza Yuki、Kawa Keisei、Kato Koji
  • Journal Title: International Journal of Hematology Volume: 109 Issue: 4 Pages: 491-498
  • DOI: 10.1007/s12185-019-02601-5
  • NAID: 120006652420
  • Peer Reviewed
• [Journal Article] Integrated molecular profiling of juvenile myelomonocytic leukemia (2018)
  • Author(s): Murakami N, Okuno Y, Yoshida K, Shiraishi Y, Nagae G, Suzuki K, Narita A, Sakaguchi H, Kawashima N, Wang X, Xu Y, Chiba K, Tanaka H, Hama A, Sanada M, Ito M, Hirayama M, Watanabe A, Ueno T, Kojima S, Aburatani H, Mano H, Miyano S, Ogawa S, Takahashi Y, Muramatsu H
  • Journal Title: Blood Volume: 131 Issue: 14 Pages: 1576-1586
  • DOI: 10.1182/blood-2017-07-798157
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Whole-exome analysis to detect congenital hemolytic anemia mimicking congenital dyserythropoietic anemia (2018)
  • Author(s): Hamada Motoharu、Doisaki Sayoko、Okuno Yusuke、Muramatsu Hideki、Hama Asahito、Kawashima Nozomu、Narita Atsushi、Nishio Nobuhiro、Yoshida Kenichi、Kanno Hitoshi、Manabe Atsushi、Taga Takashi、Takahashi Yoshiyuki、Miyano Satoru、Ogawa Seishi、Kojima Seiji
  • Journal Title: International Journal of Hematology Volume: 108 Issue: 3 Pages: 306-311
  • DOI: 10.1007/s12185-018-2482-7
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Integration Mapping of piggyBac-Mediated CD19 Chimeric Antigen Receptor T Cells Analyzed by Novel Tagmentation-Assisted PCR (2018)
  • Author(s): Hamada Motoharu、Nishio Nobuhiro、Okuno Yusuke、Suzuki Satoshi、Kawashima Nozomu、Nakazawa Yozo、Takahashi Yoshiyuki、et al
  • Journal Title: EBioMedicine Volume: 34 Pages: 18-26
  • DOI: 10.1016/j.ebiom.2018.07.008
  • Peer Reviewed / Open Access
• [Presentation] 同種造血細胞移植において生着後に見られる好中球減少症 (2020)
  • Author(s): 川島希、今屋雅之、吉田太郎、山森彩子、若松学、 三輪田俊介、成田幸太郎、北澤宏展、濱田太立、市川大輔、西川英里、奥野友介、成田敦、西尾信博、小島 勢二、高橋 義行
  • Organizer: 第42回日本造血細胞移植学会総会
• [Presentation] 自己炎症疾患におけるプロテアソーム・サブユニットの異常が優性阻害によりプロテアソーム機能を喪失させる (2020)
  • Author(s): 川島希、片岡伸介、村松秀城、大西秀典、奥野友介、今屋雅之、吉田太郎、山森彩子、若松学、 三輪田俊介、成田幸太郎、濱田太立、市川大輔、西川英里、成田敦、西尾信博、小島 勢二、高橋 義行
  • Organizer: 第82回日本血液学会学術集会
• [Presentation] ファンコニ貧血を背景にモノソミー７を有する骨髄異形成症候群に対するアザシチジンの効果 (2020)
  • Author(s): 川島希、伊藤雅文、成田幸太郎、市川大輔、西川英里、成田敦、村松秀城、西尾信博、小島勢二、高橋義行
  • Organizer: 第62回日本小児血液・がん学会学術集会
• [Presentation] 同種造血細胞移植後の閉塞性細気管支炎症候群における抗エピプラキン抗体の検出 (2019)
  • Author(s): 川島希、西川英里、土坂享成、室慶直、橋本隆、三輪田俊介、成田幸太郎、片岡伸介、濱田太立、村上典寛、市川大輔、鈴木喬悟、北澤宏展、谷口理恵子、成田敦、奥野友介、西尾信博、村松秀城、小島勢二、高橋義行
  • Organizer: 第41回日本造血細胞移植学会総会
• [Presentation] CART therapy for Pediatric ALL based on NGS MRD (2019)
  • Author(s): Nozomu Kawashima, Seiji Kojima
  • Organizer: GIMI 2019 Scientific Meeting, Shenzhen, PRC
  • Int'l Joint Research / Invited
• [Presentation] Integrating functional analysis with high-throughput sequencing for diagnosing Fanconi anemia (2019)
  • Author(s): Nozomu Kawashima
  • Organizer: The 26th Annual Meeting of the Japan Childhood Aplastic Anemia Study Group
  • Int'l Joint Research
• [Presentation] 小児血液・腫瘍医からみた 血液・がん疾患に関連する皮膚病変 (2019)
  • Author(s): 川島希
  • Organizer: 第118回日本皮膚科学会総会
  • Invited
• [Presentation] 小児がん拠点病院における患者ニーズ調査：漢方医学と現代医学の併用 (2019)
  • Author(s): 川島希
  • Organizer: 第70回日本東洋医学会学術総会
• [Presentation] 日本の小児伝統医学：略史と歴代小児科書 (2019)
  • Author(s): 川島希
  • Organizer: 第3回日本小児漢方懇話会フォーラム
  • Invited
• [Presentation] ファンコニ貧血患者におけるp53高発現とTP53変異の関係 (2019)
  • Author(s): 川島希、片岡伸介、奥野友介、村松秀城、伊藤雅文、若松学、三輪田俊介、成田幸太郎、濱田太立、市川大輔、北澤宏展、西川英里、谷口理恵子、成田敦、西尾信博、小島勢二、高橋義行
  • Organizer: 第81回日本血液学会学術集会
• [Presentation] ファンコニ貧血診断における次世代シークエンス解析とFANCD2 機能解析の統合の意義 (2019)
  • Author(s): 川島希、奥野友介、村松秀城、若松学、吉田太郎、今屋雅之、山森彩子、三輪田俊介、成田幸太郎、濱田太立、市川大輔、北澤宏展、西川英里、谷口理恵子、成田敦、西尾信博、小島勢二、高橋義行
  • Organizer: 第61回日本小児血液・がん学会学術集会
• [Presentation] 伝統小児医学の現代小児科学への応用 (2019)
  • Author(s): 川島希
  • Organizer: 第43回「漢方研究」イスクラ奨励賞受賞記念講演
  • Invited
• [Presentation] Overviewing Japanese Traditional medicine, Kampo medicine (2018)
  • Author(s): Kawashima Nozomu
  • Organizer: 1st International Traditional and Complementary Medicine Congress
  • Int'l Joint Research / Invited
• [Presentation] Overviewing Japanese Traditional medicine, Kampo medicine (2018)
  • Author(s): Kawashima Nozomu
  • Organizer: 2nd Kampo Symposium at the Clinic for Gastroenterology and Gastrointestinal Oncology at the University Medicine, G?ttingen
  • Invited
• [Presentation] 集中治療領域での漢方の底力 ショックと大量胸水に対して漢方エキス製剤が治療奏効した一例 (2018)
  • Author(s): 川島希
  • Organizer: 第69回日本東洋医学会学術総会
  • Invited
• [Presentation] 小児漢方エッセンス２ 「小児漢方医学史」 (2018)
  • Author(s): 川島希
  • Organizer: 第2回日本小児漢方懇話会フォーラム
  • Invited
• [Presentation] The History of Japanese Pediatric Kampo Medicine and its Application to Modern Medicine (2018)
  • Author(s): Kawashima Nozomu
  • Organizer: 天津中医薬大学建学60周年記念式典及び学術フォーラム
  • Int'l Joint Research / Invited
• [Presentation] 明治期皇子女と漢方医 なぜ漢方医が皇子女の主治医となり最終的に罷免に至ったか？ (2018)
  • Author(s): 川島希
  • Organizer: 第46回日本小児東洋医学会学術集会
• [Presentation] 小児がん拠点病院単一施設における漢方診療の患者ニーズ調査 (2018)
  • Author(s): 川島希、三輪田俊介、成田幸太郎、片岡伸介、濱田太立、村上典寛、市川大輔、鈴木喬悟、北澤宏展、西川英里、奥野友介、谷口理恵子、成田敦、村松秀城、西尾信博、小島勢二、高橋義行
  • Organizer: 第60回日本小児血液・がん学会学術集会
• [Remarks] 村瀬豆洲 『幼幼家則』 現代語訳（パイロット版）
  • URL: http://www.konwa-kids.com/%E5%B9%BC%E5%B9%BC%E5%AE%B6%E5%89%87/