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New tailor-made nutritional guidance based on bitter taste sensitivity and its genetic polymorphism analysis in Japanese people.

Research Project

Project/Area Number 18K13020
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 08030:Family and consumer sciences, and culture and living-related
Research InstitutionTohoku Seikatsu Bunka College

Principal Investigator

Yamaki Michiko  東北生活文化大学, 家政学部, 講師 (50382677)

Project Period (FY) 2018-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2020: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2019: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords味覚 / 苦味受容体(TAS2Rs) / 遺伝子多型 / 個人差 / 苦味受容体(TAS2R) / 苦味受容体(TAS2R) / 苦味受容体(TAS2Rs) / 一塩基多型(SNP) / 遺伝子解析 / テーラーメイド栄養指導
Outline of Final Research Achievements

Bitter substances are perceived by bitter taste receptors (TAS2Rs). The TAS2R38 gene polymorphisms influence individual differences in bitterness sensitivity to some typical artificial bitter substance, e.g., phenylthiocarbamide (PTC) for TAS2R38, but the effect of genetic factors on the bitterness sensitivity to other bitter components in foods is not clear. In this study, we conducted a questionnaire survey on sensory evaluation tests and taste preference, focusing on vegetables and fruits containing bitter substances that are thought to have an impact on the frequency of daily intake , especially on cruciferous vegetables and grapefruit. Furthermore, we investigated the relationship between TAS2Rs (38, 46 and 19) gene polymorphisms and bitter taste sensitivity.

Academic Significance and Societal Importance of the Research Achievements

抗がん作用のあるアブラナ科野菜の苦味感受性や嗜好性について報告がなされているが(Sandell et al. 2006; Shen et al. 2016等)これら先行研究によって統一されたものではなく、その消費量はTAS2R38の遺伝子型間で有意な差がないとも報告されている( Feeney et al 2014; Inoue et al. 2013; Choi et al. 2016)。一方、日本人では前述の様なアンケート調査や官能評価試験があまり実施されおらず、このような調査を実施することで日本人の遺伝子多型の特徴を明らかにすることが可能になり、学術的意義がある。

Report

(6 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (6 results)

All 2021 2019 2018

All Presentation (6 results) (of which Int'l Joint Research: 2 results)

  • [Presentation] 苦味感受性の個人差と苦味受容体TAS2Rsの一塩基多型との関連性2021

    • Author(s)
      八巻美智子 、齋藤弘貴 、磯野邦夫 、後藤知子 、庄司憲明 、白川仁 、駒井三千夫
    • Organizer
      日本味と匂学会 第55回大会
    • Related Report
      2021 Research-status Report
  • [Presentation] アブラナ科野菜の苦味感受性の個人差と苦味受容体TAS2Rの遺伝子多型に関する研究2019

    • Author(s)
      八巻美智子、齋藤弘貴、磯野邦夫、後藤知子、白川仁、駒井三千夫
    • Organizer
      第53回味と匂学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 大学生の苦味に関する味嗜好調査2019

    • Author(s)
      八巻美智子、佐藤明日香、寺島萌美、藏美佐子、坂本妃奈子、千葉郁奈、駒井三千夫
    • Organizer
      日本家政学会 東北・北海道支部 第63回研究発表会
    • Related Report
      2019 Research-status Report
  • [Presentation] Genetic polymorphism of human bitter taste receptors in the defense system against cancers2018

    • Author(s)
      Michiko Yamaki, HirokiSaito, Kunio Isono,Shizuko Satoh-Kuriwada, Noriaki Shoji, Tomoko Goto, Hitoshi Shirakawa, Michio Komai
    • Organizer
      Asia-Pacific Nutrigenomics & Nutrigenetics Organisation
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Evaluation of the Correlation between Bitterness Sensitivities to PTC / PROP (TAS2R38 SNP) and to Grapefruit Genotype (TAS2R19 SNP)2018

    • Author(s)
      Hiroki Saito, Michiko Yamaki,Yukiko Numakura,Maiko Iribe, Asumi Ishikura,Kunio Isono, Tomoko Goto, Hitoshi Shirakawa, Michio Komai
    • Organizer
      Asia-Pacific Nutrigenomics & Nutrigenetics Organisation
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 異なる苦味感受性をもたらす遺伝的変異と味嗜好性2018

    • Author(s)
      佐藤明日香、寺島萌美、藏美佐子、坂本妃奈子、千葉郁奈、八巻美智子、駒井三千夫
    • Organizer
      日本家政学会東北・北海道支部第62回研究発表会
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2024-12-25  

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