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Constructing a Learning Design for Schizophrenia with a Focus on Timing Impairment

Research Project

Project/Area Number 18K13363
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 10030:Clinical psychology-related
Research InstitutionNational Center of Neurology and Psychiatry

Principal Investigator

Ueda Natsuki  国立研究開発法人国立精神・神経医療研究センター, 精神保健研究所 行動医学研究部, リサーチフェロー (50807922)

Project Period (FY) 2018-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords時間知覚 / 知覚推論 / 精神疾患 / 統計モデル / 統合失調症 / トゥレット症候群 / 知覚学習 / 時間感覚 / 陰性症状 / 認知機能 / 感覚推定 / 学習支援 / 注意機能 / 就業支援
Outline of Final Research Achievements

The purpose of this study was to clarify changes in time perception in schizophrenia. First, we focused on dopaminergic changes related to psychological time in neurological disorders such as schizophrenia and Tourette's syndrome, and found the changes in time perception in these disorders. In addition to this, based on a hypothesis that patients with schizophrenia are associated with an abnormal weighting of prior in perceptual inference, we conducted behavioral experiments and found changes in the strategies of perceptual inference in patients with schizophrenia.

Academic Significance and Societal Importance of the Research Achievements

精神疾患における知覚の変化については古くから報告されているものの未だ不明な点が多く,治療標的は未だ不明な点が多い.本研究により,統合失調症の時間知覚における認知的方略の変化を明らかにしたことは精神疾患症状の発生メカニズムの解明に寄与するものであると考える.

Report

(6 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (9 results)

All 2023 2022 2020 2019 2018 Other

All Int'l Joint Research (1 results) Journal Article (5 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 5 results,  Open Access: 5 results) Presentation (3 results) (of which Int'l Joint Research: 2 results)

  • [Int'l Joint Research] University of Nottingham(英国)

    • Related Report
      2022 Annual Research Report
  • [Journal Article] Memory Decay Enhances Central Bias in Time Perception2022

    • Author(s)
      Natsuki Ueda, Kanji Tanaka, Katsumi Watanabe
    • Journal Title

      i-Perception

      Volume: 13-6 Issue: 6

    • DOI

      10.1177/20416695221140428

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Perceptual inference, accuracy, and precision in temporal reproduction in schizophrenia2022

    • Author(s)
      Ueda Natsuki、Tanaka Kanji、Maruo Kazushi、Roach Neil、Sumiyoshi Tomiki、Watanabe Katsumi、Hanakawa Takashi
    • Journal Title

      Schizophrenia Research: Cognition

      Volume: 28 Pages: 100229-100229

    • DOI

      10.1016/j.scog.2021.100229

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Time estimation in a case of Tourette’s syndrome; Effect of antipsychotic medications2020

    • Author(s)
      T, Inagawa., N, Ueda., K, Nakagome., T, Sumiyoshi
    • Journal Title

      Neuropsychopharmacology Reports

      Volume: 00 Issue: 2 Pages: 1-3

    • DOI

      10.1002/npr2.12101

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Neural correlates of temporal updating and reasoning in association with neuropsychiatric disorders2019

    • Author(s)
      N, Ueda., T, Hanakawa
    • Journal Title

      Behavioral and Brain Sciences

      Volume: 42

    • DOI

      10.1017/s0140525x19000426

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Positive symptoms and time perception in schizophrenia: A meta-analysis2019

    • Author(s)
      Natsuki Ueda, Kazushi Maruo, and Tomiki Sumiyoshi
    • Journal Title

      Schizophrenia Research: Cognition

      Volume: 13 Pages: 3-6

    • DOI

      10.1016/j.scog.2018.07.002

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Interval estimate in Schizophrenia: the effect of central tendency bias and serial dependency2023

    • Author(s)
      Natsuki Ueda, Neil Roach
    • Organizer
      Timing Research Forum
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Increased central bias in time reproduction in schizophrenia with predominantly positive symptoms2019

    • Author(s)
      Natsuki Uedaa, Kanji Tanaka, Kazushi Maruo, Tomiki Sumiyoshi, Katsumi Watanabee, & Takashi Hanakawa
    • Organizer
      WPA 2019 World Congress of Psychiatry
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Altered time perception is associated with positive symptoms of schizophrenia: A meta-analysis2018

    • Author(s)
      Ueda N, Maruo K, Wada K, Sumiyoshi T
    • Organizer
      The 41st Annual Meeting of the Japan Neuroscience Society
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2024-01-30  

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